| 1 |
ORBIMED ADVISORS LLC |
5,702,000 |
11,689,000 |
16.48% |
|
|
| 2 |
BlackRock Fund Advisors |
3,271,601 |
6,707,000 |
9.46% |
|
|
| 3 |
First Eagle Investment Management, LLC |
2,843,599 |
5,829,000 |
8.22% |
|
|
| 4 |
VANGUARD GROUP INC |
2,719,968 |
5,576,000 |
7.86% |
|
|
| 5 |
NEA Management Company, LLC |
2,520,316 |
5,167,000 |
7.28% |
|
|
| 6 |
BVF INC/IL |
2,449,387 |
5,021,000 |
7.08% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
2,385,147 |
4,890,000 |
6.89% |
|
|
| 8 |
FARALLON CAPITAL MANAGEMENT LLC |
1,258,732 |
2,580,000 |
3.64% |
|
|
| 9 |
STATE STREET CORP |
1,001,631 |
2,052,000 |
2.89% |
|
|
| 10 |
FMR LLC |
904,877 |
1,855,000 |
2.62% |
|
|
| 11 |
NORTHERN TRUST CORP |
770,043 |
1,578,000 |
2.22% |
|
|
| 12 |
TFS CAPITAL LLC |
754,926 |
1,548,000 |
2.18% |
|
|
| 13 |
BLACKROCK ADVISORS LLC |
688,142 |
1,411,000 |
1.99% |
|
|
| 14 |
Bank of New York Mellon Corp |
491,584 |
1,008,000 |
1.42% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
402,500 |
825,000 |
1.16% |
|
|
| 16 |
DIMENSIONAL FUND ADVISORS LP |
396,020 |
812,000 |
1.14% |
|
|
| 17 |
PRINCIPAL FINANCIAL GROUP INC |
359,912 |
738,000 |
1.04% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
278,618 |
571,000 |
0.81% |
|
|
| 19 |
D. E. Shaw & Co., Inc. |
273,341 |
560,000 |
0.79% |
|
|
| 20 |
RENAISSANCE TECHNOLOGIES LLC |
262,583 |
538,000 |
0.76% |
|
|
| 21 |
JPMORGAN CHASE & CO |
258,480 |
530,000 |
0.75% |
|
|
| 22 |
AMERIPRISE FINANCIAL INC |
244,665 |
502,000 |
0.71% |
|
|
| 23 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
244,262 |
501,000 |
0.71% |
|
|
| 24 |
State of New Jersey Common Pension Fund A |
223,774 |
459,000 |
0.65% |
|
|
| 25 |
ROYCE & ASSOCIATES LP |
200,000 |
410,000 |
0.58% |
|
|
| 26 |
BlackRock Investment Management, LLC |
196,658 |
403,000 |
0.57% |
|
|
| 27 |
NEW YORK STATE TEACHERS RETIREMENT SYSTEM |
191,473 |
393,000 |
0.55% |
|
|
| 28 |
NJ State Employees Deferred Compensation Plan |
190,000 |
390,000 |
0.55% |
|
|
| 29 |
GOLDMAN SACHS GROUP INC |
150,581 |
309,000 |
0.44% |
|
|
| 30 |
Invesco Ltd. |
145,848 |
299,000 |
0.42% |
|
|
| 31 |
NEW YORK STATE COMMON RETIREMENT FUND |
128,139 |
263,000 |
0.37% |
|
|
| 32 |
PRUDENTIAL FINANCIAL INC |
121,393 |
249,000 |
0.35% |
|
|
| 33 |
ALGERT GLOBAL LLC |
119,790 |
246,000 |
0.35% |
|
|
| 34 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
122,900 |
245,000 |
0.35% |
|
|
| 35 |
PUBLIC SECTOR PENSION INVESTMENT BOARD |
110,386 |
226,000 |
0.32% |
|
|
| 36 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
106,810 |
219,000 |
0.31% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
104,300 |
214,000 |
0.30% |
|
|
| 38 |
OPPENHEIMER & CO INC |
102,050 |
209,000 |
0.29% |
|
|
| 39 |
BANK OF AMERICA CORP /DE/ |
90,933 |
186,000 |
0.26% |
|
|
| 40 |
SHEPHERD KAPLAN KROCHUK, LLC |
90,300 |
185,000 |
0.26% |
|
|
| 41 |
Connor, Clark & Lunn Investment Management Ltd. |
80,100 |
181,000 |
0.26% |
|
|
| 42 |
CREDIT SUISSE AG/ |
84,119 |
172,000 |
0.24% |
|
|
| 43 |
DENVER INVESTMENT ADVISORS LLC |
80,378 |
165,000 |
0.23% |
|
|
| 44 |
TEACHERS ADVISORS, LLC |
76,260 |
156,000 |
0.22% |
|
|
| 45 |
A.R.T. Advisors, LLC |
74,201 |
152,000 |
0.21% |
|
|
| 46 |
STONERIDGE INVESTMENT PARTNERS LLC |
70,737 |
145,000 |
0.20% |
|
|
| 47 |
CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. |
68,200 |
140,000 |
0.20% |
|
|
| 48 |
RHUMBLINE ADVISERS |
62,813 |
129,000 |
0.18% |
|
|
| 49 |
ProShare Advisors LLC |
61,243 |
126,000 |
0.18% |
|
|
| 50 |
MORGAN STANLEY |
56,934 |
117,000 |
0.16% |
|
|
