| 1 |
BVF INC/IL |
6,174,561 |
13,831,000 |
18.38% |
|
|
| 2 |
First Eagle Investment Management, LLC |
5,719,968 |
12,813,000 |
17.03% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
4,896,108 |
10,967,000 |
14.57% |
|
|
| 4 |
VANGUARD GROUP INC |
2,667,402 |
5,975,000 |
7.94% |
|
|
| 5 |
NEA Management Company, LLC |
2,520,316 |
5,646,000 |
7.50% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
2,015,036 |
4,514,000 |
6.00% |
|
|
| 7 |
RENAISSANCE TECHNOLOGIES LLC |
1,873,783 |
4,197,000 |
5.58% |
|
|
| 8 |
Nantahala Capital Management, LLC |
1,730,859 |
3,877,000 |
5.15% |
|
|
| 9 |
D. E. Shaw & Co., Inc. |
888,602 |
1,991,000 |
2.65% |
|
|
| 10 |
FMR LLC |
670,600 |
1,502,000 |
2.00% |
|
|
| 11 |
TFS CAPITAL LLC |
466,472 |
1,045,000 |
1.39% |
|
|
| 12 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
331,836 |
743,000 |
0.99% |
|
|
| 13 |
DIMENSIONAL FUND ADVISORS LP |
306,946 |
688,000 |
0.91% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
293,317 |
657,000 |
0.87% |
|
|
| 15 |
STONERIDGE INVESTMENT PARTNERS LLC |
247,153 |
554,000 |
0.74% |
|
|
| 16 |
State of New Jersey Common Pension Fund D |
223,774 |
501,000 |
0.67% |
|
|
| 17 |
TWO SIGMA INVESTMENTS, LP |
204,997 |
459,000 |
0.61% |
|
|
| 18 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
200,331 |
449,000 |
0.60% |
|
|
| 19 |
NJ State Employees Deferred Compensation Plan |
190,000 |
426,000 |
0.57% |
|
|
| 20 |
BlackRock Fund Advisors |
164,037 |
367,000 |
0.49% |
|
|
| 21 |
Spark Investment Management LLC |
143,900 |
320,000 |
0.43% |
|
|
| 22 |
Nine Chapters Capital Management LLC |
142,500 |
319,000 |
0.42% |
|
|
| 23 |
A.R.T. Advisors, LLC |
133,742 |
299,000 |
0.40% |
|
|
| 24 |
NORTHERN TRUST CORP |
130,259 |
291,000 |
0.39% |
|
|
| 25 |
ALGERT GLOBAL LLC |
119,790 |
268,000 |
0.36% |
|
|
| 26 |
MILLENNIUM MANAGEMENT LLC |
117,372 |
263,000 |
0.35% |
|
|
| 27 |
TWO SIGMA ADVISERS, LP |
116,800 |
262,000 |
0.35% |
|
|
| 28 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
225,900 |
253,000 |
0.34% |
|
|
| 29 |
NEW YORK STATE COMMON RETIREMENT FUND |
111,428 |
250,000 |
0.33% |
|
|
| 30 |
GOLDMAN SACHS GROUP INC |
98,717 |
221,000 |
0.29% |
|
|
| 31 |
Connor, Clark & Lunn Investment Management Ltd. |
80,800 |
181,000 |
0.24% |
|
|
| 32 |
Bank of New York Mellon Corp |
76,249 |
171,000 |
0.23% |
|
|
| 33 |
Rotella Capital Management, Inc. |
51,050 |
114,000 |
0.15% |
|
|
| 34 |
OPPENHEIMER & CO INC |
46,000 |
103,000 |
0.14% |
|
|
| 35 |
RUSSELL FRANK CO/ |
41,800 |
94,000 |
0.12% |
|
|
| 36 |
STATE STREET CORP |
40,795 |
92,000 |
0.12% |
|
|
| 37 |
MORGAN STANLEY |
39,977 |
90,000 |
0.12% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
28,416 |
63,000 |
0.08% |
|
|
| 39 |
CREDIT SUISSE AG/ |
25,448 |
57,000 |
0.08% |
|
|
| 40 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,000 |
48,000 |
0.06% |
|
|
| 41 |
BLACKROCK ADVISORS LLC |
20,616 |
46,000 |
0.06% |
|
|
| 42 |
Airain ltd |
16,392 |
37,000 |
0.05% |
|
|
| 43 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
15,377 |
34,000 |
0.05% |
|
|
| 44 |
CITADEL ADVISORS LLC |
14,919 |
33,000 |
0.04% |
|
|
| 45 |
SG Americas Securities, LLC |
12,186 |
27,000 |
0.04% |
|
|
| 46 |
GUGGENHEIM CAPITAL LLC |
10,191 |
23,000 |
0.03% |
|
|
| 47 |
BlackRock Investment Management, LLC |
10,006 |
22,000 |
0.03% |
|
|
| 48 |
UBS Group AG |
8,286 |
18,000 |
0.02% |
|
|
| 49 |
ROYAL BANK OF CANADA |
6,500 |
15,000 |
0.02% |
|
|
| 50 |
GROUP ONE TRADING LLC |
3,488 |
8,000 |
0.01% |
|
|
