| 1 |
ORBIMED ADVISORS LLC |
5,702,000 |
8,838,000 |
18.77% |
|
|
| 2 |
BVF INC/IL |
3,124,887 |
4,844,000 |
10.29% |
|
|
| 3 |
First Eagle Investment Management, LLC |
2,843,599 |
4,408,000 |
9.36% |
|
|
| 4 |
NEA Management Company, LLC |
2,520,316 |
3,906,000 |
8.30% |
|
|
| 5 |
VANGUARD GROUP INC |
2,329,735 |
3,611,000 |
7.67% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
1,888,324 |
2,927,000 |
6.22% |
|
|
| 7 |
FMR LLC |
1,343,907 |
2,083,000 |
4.42% |
|
|
| 8 |
FARALLON CAPITAL MANAGEMENT LLC |
1,258,732 |
1,951,000 |
4.14% |
|
|
| 9 |
RENAISSANCE TECHNOLOGIES LLC |
1,102,168 |
1,708,000 |
3.63% |
|
|
| 10 |
BLACKROCK ADVISORS LLC |
879,405 |
1,363,000 |
2.90% |
|
|
| 11 |
D. E. Shaw & Co., Inc. |
762,540 |
1,182,000 |
2.51% |
|
|
| 12 |
NORTHERN TRUST CORP |
647,378 |
1,003,000 |
2.13% |
|
|
| 13 |
TWO SIGMA INVESTMENTS, LP |
396,305 |
614,000 |
1.30% |
|
|
| 14 |
TFS CAPITAL LLC |
377,028 |
584,000 |
1.24% |
|
|
| 15 |
DIMENSIONAL FUND ADVISORS LP |
357,103 |
554,000 |
1.18% |
|
|
| 16 |
JPMORGAN CHASE & CO |
326,843 |
507,000 |
1.08% |
|
|
| 17 |
GOLDMAN SACHS GROUP INC |
300,601 |
466,000 |
0.99% |
|
|
| 18 |
Paloma Partners Management Co |
253,496 |
393,000 |
0.83% |
|
|
| 19 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
252,500 |
391,000 |
0.83% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
250,457 |
388,000 |
0.82% |
|
|
| 21 |
BANK OF AMERICA CORP /DE/ |
249,280 |
387,000 |
0.82% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
225,900 |
350,000 |
0.74% |
|
|
| 23 |
State of New Jersey Common Pension Fund D |
223,774 |
347,000 |
0.74% |
|
|
| 24 |
ROYCE & ASSOCIATES LP |
200,000 |
310,000 |
0.66% |
|
|
| 25 |
NJ State Employees Deferred Compensation Plan |
190,000 |
295,000 |
0.63% |
|
|
| 26 |
BlackRock Fund Advisors |
174,462 |
270,000 |
0.57% |
|
|
| 27 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
169,782 |
263,000 |
0.56% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
165,405 |
256,000 |
0.54% |
|
|
| 29 |
TWO SIGMA ADVISERS, LP |
144,600 |
224,000 |
0.48% |
|
|
| 30 |
LMR Partners LLP |
128,439 |
199,000 |
0.42% |
|
|
| 31 |
OPPENHEIMER & CO INC |
123,050 |
191,000 |
0.41% |
|
|
| 32 |
ALGERT GLOBAL LLC |
119,790 |
186,000 |
0.40% |
|
|
| 33 |
CREDIT SUISSE AG/ |
94,134 |
146,000 |
0.31% |
|
|
| 34 |
Connor, Clark & Lunn Investment Management Ltd. |
80,100 |
132,000 |
0.28% |
|
|
| 35 |
DENVER INVESTMENT ADVISORS LLC |
80,378 |
125,000 |
0.27% |
|
|
| 36 |
SOROS FUND MANAGEMENT LLC |
78,600 |
122,000 |
0.26% |
|
|
| 37 |
Bank of New York Mellon Corp |
75,999 |
118,000 |
0.25% |
|
|
| 38 |
A.R.T. Advisors, LLC |
74,201 |
115,000 |
0.24% |
|
|
| 39 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
73,625 |
114,000 |
0.24% |
|
|
| 40 |
SHEPHERD KAPLAN KROCHUK, LLC |
71,890 |
111,000 |
0.24% |
|
|
| 41 |
MILLENNIUM MANAGEMENT LLC |
69,531 |
108,000 |
0.23% |
|
|
| 42 |
STONERIDGE INVESTMENT PARTNERS LLC |
68,712 |
107,000 |
0.23% |
|
|
| 43 |
CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. |
49,600 |
76,000 |
0.16% |
|
|
| 44 |
JANE STREET GROUP, LLC |
48,000 |
74,000 |
0.16% |
|
|
| 45 |
STATE STREET CORP |
44,195 |
68,000 |
0.14% |
|
|
| 46 |
VOYA INVESTMENT MANAGEMENT LLC |
42,056 |
65,000 |
0.14% |
|
|
| 47 |
CITADEL ADVISORS LLC |
41,619 |
65,000 |
0.14% |
|
|
| 48 |
MORGAN STANLEY |
41,012 |
63,000 |
0.13% |
|
|
| 49 |
Nine Chapters Capital Management LLC |
38,700 |
60,000 |
0.13% |
|
|
| 50 |
BARCLAYS PLC |
46,072 |
46,000 |
0.10% |
|
|
