| 1 |
ORBIMED ADVISORS LLC |
5,702,000 |
6,386,000 |
20.29% |
|
|
| 2 |
BVF INC/IL |
4,300,887 |
4,817,000 |
15.30% |
|
|
| 3 |
First Eagle Investment Management, LLC |
2,843,599 |
3,185,000 |
10.12% |
|
|
| 4 |
NEA Management Company, LLC |
2,520,316 |
2,823,000 |
8.97% |
|
|
| 5 |
VANGUARD GROUP INC |
2,368,659 |
2,653,000 |
8.43% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
1,963,436 |
2,199,000 |
6.99% |
|
|
| 7 |
FMR LLC |
1,523,005 |
1,706,000 |
5.42% |
|
|
| 8 |
RENAISSANCE TECHNOLOGIES LLC |
1,120,035 |
1,254,000 |
3.98% |
|
|
| 9 |
BLACKROCK ADVISORS LLC |
904,605 |
1,013,000 |
3.22% |
|
|
| 10 |
D. E. Shaw & Co., Inc. |
778,227 |
871,000 |
2.77% |
|
|
| 11 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
352,500 |
395,000 |
1.25% |
|
|
| 12 |
DIMENSIONAL FUND ADVISORS LP |
343,132 |
384,000 |
1.22% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
246,502 |
276,000 |
0.88% |
|
|
| 14 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
225,900 |
253,000 |
0.80% |
|
|
| 15 |
State of New Jersey Common Pension Fund D |
223,774 |
251,000 |
0.80% |
|
|
| 16 |
GOLDMAN SACHS GROUP INC |
218,444 |
245,000 |
0.78% |
|
|
| 17 |
ROYCE & ASSOCIATES LP |
200,000 |
224,000 |
0.71% |
|
|
| 18 |
TWO SIGMA INVESTMENTS, LP |
195,200 |
219,000 |
0.70% |
|
|
| 19 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
191,768 |
215,000 |
0.68% |
|
|
| 20 |
NJ State Employees Deferred Compensation Plan |
190,000 |
213,000 |
0.68% |
|
|
| 21 |
BlackRock Fund Advisors |
162,647 |
182,000 |
0.58% |
|
|
| 22 |
NORTHERN TRUST CORP |
143,302 |
160,000 |
0.51% |
|
|
| 23 |
OPPENHEIMER & CO INC |
123,050 |
138,000 |
0.44% |
|
|
| 24 |
TWO SIGMA ADVISERS, LP |
120,400 |
135,000 |
0.43% |
|
|
| 25 |
ALGERT GLOBAL LLC |
119,790 |
134,000 |
0.43% |
|
|
| 26 |
TFS CAPITAL LLC |
118,515 |
133,000 |
0.42% |
|
|
| 27 |
MILLENNIUM MANAGEMENT LLC |
103,329 |
116,000 |
0.37% |
|
|
| 28 |
STONERIDGE INVESTMENT PARTNERS LLC |
100,025 |
112,000 |
0.36% |
|
|
| 29 |
Connor, Clark & Lunn Investment Management Ltd. |
80,100 |
90,000 |
0.29% |
|
|
| 30 |
Bank of New York Mellon Corp |
75,999 |
85,000 |
0.27% |
|
|
| 31 |
A.R.T. Advisors, LLC |
74,201 |
83,000 |
0.26% |
|
|
| 32 |
Nine Chapters Capital Management LLC |
57,400 |
64,000 |
0.20% |
|
|
| 33 |
Spark Investment Management LLC |
53,800 |
60,000 |
0.19% |
|
|
| 34 |
SHEPHERD KAPLAN KROCHUK, LLC |
53,890 |
60,000 |
0.19% |
|
|
| 35 |
STATE STREET CORP |
44,195 |
49,000 |
0.16% |
|
|
| 36 |
OXFORD ASSET MANAGEMENT LLP |
42,592 |
48,000 |
0.15% |
|
|
| 37 |
CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. |
41,000 |
46,000 |
0.15% |
|
|
| 38 |
Virtu KCG Holdings LLC |
35,433 |
40,000 |
0.13% |
|
|
| 39 |
LMR Partners LLP |
27,670 |
31,000 |
0.10% |
|
|
| 40 |
Rotella Capital Management, Inc. |
21,846 |
24,000 |
0.08% |
|
|
| 41 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,000 |
24,000 |
0.08% |
|
|
| 42 |
CREDIT SUISSE AG/ |
19,344 |
22,000 |
0.07% |
|
|
| 43 |
PRELUDE CAPITAL MANAGEMENT, LLC |
13,100 |
15,000 |
0.05% |
|
|
| 44 |
MORGAN STANLEY |
14,059 |
15,000 |
0.05% |
|
|
| 45 |
BlackRock Investment Management, LLC |
10,394 |
12,000 |
0.04% |
|
|
| 46 |
ROYAL BANK OF CANADA |
7,700 |
9,000 |
0.03% |
|
|
| 47 |
Nationwide Fund Advisors |
2,846 |
3,000 |
0.01% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,233 |
3,000 |
0.01% |
|
|
| 49 |
CITIGROUP INC |
802 |
1,000 |
0.00% |
|
|
| 50 |
GROUP ONE TRADING LLC |
1,328 |
1,000 |
0.00% |
|
|
