| 1 |
ORBIMED ADVISORS LLC |
5,702,000 |
6,956,000 |
19.00% |
|
|
| 2 |
BVF INC/IL |
4,723,811 |
5,763,000 |
15.74% |
|
|
| 3 |
First Eagle Investment Management, LLC |
4,444,899 |
5,423,000 |
14.81% |
|
|
| 4 |
VANGUARD GROUP INC |
2,544,182 |
3,104,000 |
8.48% |
|
|
| 5 |
NEA Management Company, LLC |
2,520,316 |
3,075,000 |
8.40% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
1,986,196 |
2,423,000 |
6.62% |
|
|
| 7 |
RENAISSANCE TECHNOLOGIES LLC |
1,532,767 |
1,870,000 |
5.11% |
|
|
| 8 |
FMR LLC |
1,503,938 |
1,835,000 |
5.01% |
|
|
| 9 |
D. E. Shaw & Co., Inc. |
850,276 |
1,037,000 |
2.83% |
|
|
| 10 |
DIMENSIONAL FUND ADVISORS LP |
324,931 |
396,000 |
1.08% |
|
|
| 11 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
318,844 |
389,000 |
1.06% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
247,078 |
301,000 |
0.82% |
|
|
| 13 |
STONERIDGE INVESTMENT PARTNERS LLC |
239,515 |
292,000 |
0.80% |
|
|
| 14 |
State of New Jersey Common Pension Fund D |
223,774 |
273,000 |
0.75% |
|
|
| 15 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
225,900 |
253,000 |
0.69% |
|
|
| 16 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
200,331 |
244,000 |
0.67% |
|
|
| 17 |
ROYCE & ASSOCIATES LP |
200,000 |
244,000 |
0.67% |
|
|
| 18 |
NJ State Employees Deferred Compensation Plan |
190,000 |
232,000 |
0.63% |
|
|
| 19 |
BlackRock Fund Advisors |
175,157 |
214,000 |
0.58% |
|
|
| 20 |
Spark Investment Management LLC |
168,900 |
202,000 |
0.55% |
|
|
| 21 |
MILLENNIUM MANAGEMENT LLC |
162,158 |
198,000 |
0.54% |
|
|
| 22 |
TWO SIGMA INVESTMENTS, LP |
151,418 |
185,000 |
0.51% |
|
|
| 23 |
RUSSELL FRANK CO/ |
150,953 |
181,000 |
0.49% |
|
|
| 24 |
NORTHERN TRUST CORP |
143,648 |
176,000 |
0.48% |
|
|
| 25 |
Nine Chapters Capital Management LLC |
120,800 |
147,000 |
0.40% |
|
|
| 26 |
ALGERT GLOBAL LLC |
119,790 |
146,000 |
0.40% |
|
|
| 27 |
DEUTSCHE BANK AG\ |
115,839 |
141,000 |
0.39% |
|
|
| 28 |
TWO SIGMA ADVISERS, LP |
110,400 |
135,000 |
0.37% |
|
|
| 29 |
GOLDMAN SACHS GROUP INC |
100,519 |
123,000 |
0.34% |
|
|
| 30 |
Connor, Clark & Lunn Investment Management Ltd. |
80,100 |
98,000 |
0.27% |
|
|
| 31 |
Bank of New York Mellon Corp |
76,474 |
93,000 |
0.25% |
|
|
| 32 |
OPPENHEIMER & CO INC |
67,000 |
82,000 |
0.22% |
|
|
| 33 |
A.R.T. Advisors, LLC |
68,001 |
82,000 |
0.22% |
|
|
| 34 |
STATE STREET CORP |
40,795 |
50,000 |
0.14% |
|
|
| 35 |
Virtu KCG Holdings LLC |
37,569 |
46,000 |
0.13% |
|
|
| 36 |
CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. |
27,900 |
34,000 |
0.09% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,000 |
26,000 |
0.07% |
|
|
| 38 |
BLACKROCK ADVISORS LLC |
20,616 |
25,000 |
0.07% |
|
|
| 39 |
CREDIT SUISSE AG/ |
19,674 |
24,000 |
0.07% |
|
|
| 40 |
MORGAN STANLEY |
14,059 |
17,000 |
0.05% |
|
|
| 41 |
SHEPHERD KAPLAN KROCHUK, LLC |
13,090 |
16,000 |
0.04% |
|
|
| 42 |
CITADEL ADVISORS LLC |
10,338 |
13,000 |
0.04% |
|
|
| 43 |
GUGGENHEIM CAPITAL LLC |
10,145 |
12,000 |
0.03% |
|
|
| 44 |
BlackRock Investment Management, LLC |
9,283 |
11,000 |
0.03% |
|
|
| 45 |
UBS Group AG |
6,792 |
8,000 |
0.02% |
|
|
| 46 |
ROYAL BANK OF CANADA |
6,500 |
8,000 |
0.02% |
|
|
| 47 |
Nationwide Fund Advisors |
2,846 |
3,000 |
0.01% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,233 |
3,000 |
0.01% |
|
|
| 49 |
GROUP ONE TRADING LLC |
1,328 |
2,000 |
0.01% |
|
|
| 50 |
BANK OF AMERICA CORP /DE/ |
1 |
0 |
0.00% |
|
|
