| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 4,377,696 | 52,620,000 | 10.93% | ||
| 2 | Invesco Ltd. | 3,061,431 | 36,798,000 | 7.65% | ||
| 3 | STATE STREET CORP | 2,865,420 | 34,441,000 | 7.16% | ||
| 4 | Broadfin Capital, LLC | 2,396,399 | 28,805,000 | 5.98% | ||
| 5 | FMR LLC | 2,105,499 | 25,308,000 | 5.26% | ||
| 6 | OAK RIDGE INVESTMENTS LLC | 1,835,224 | 22,059,000 | 4.58% | ||
| 7 | VANGUARD GROUP INC | 1,506,475 | 18,108,000 | 3.76% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,286,775 | 15,467,000 | 3.21% | ||
| 9 | BlackRock Fund Advisors | 1,169,715 | 14,060,000 | 2.92% | ||
| 10 | WELLS FARGO & COMPANY/MN | 1,149,645 | 13,818,000 | 2.87% | ||
| 11 | Bank of New York Mellon Corp | 906,580 | 10,898,000 | 2.26% | ||
| 12 | MARSHALL WACE, LLP | 854,206 | 10,268,000 | 2.13% | ||
| 13 | FRONTIER CAPITAL MANAGEMENT CO LLC | 843,922 | 10,144,000 | 2.11% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 800,000 | 9,616,000 | 2.00% | ||
| 15 | Allianz Asset Management GmbH | 793,920 | 9,542,000 | 1.98% | ||
| 16 | Foresite Capital Management I, LLC | 671,092 | 8,067,000 | 1.68% | ||
| 17 | STIFEL FINANCIAL CORP | 392,923 | 7,353,000 | 1.53% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 605,407 | 7,277,000 | 1.51% | ||
| 19 | TIGER MANAGEMENT L.L.C. | 510,874 | 6,141,000 | 1.28% | ||
| 20 | CITADEL ADVISORS LLC | 475,193 | 5,712,000 | 1.19% | ||
| 21 | NORTHERN TRUST CORP | 469,644 | 5,645,000 | 1.17% | ||
| 22 | DEERFIELD MANAGEMENT COMPANY, L.P. | 464,083 | 5,578,000 | 1.16% | ||
| 23 | TIVERTON ASSET MANAGEMENT LLC | 453,984 | 5,459,000 | 1.13% | ||
| 24 | OppenheimerFunds, Inc. | 430,530 | 5,175,000 | 1.08% | ||
| 25 | Foresite Capital Management II, LLC | 393,683 | 4,732,000 | 0.98% | ||
| 26 | NEXT CENTURY GROWTH INVESTORS LLC | 386,024 | 4,640,000 | 0.96% | ||
| 27 | Timpani Capital Management LLC | 377,707 | 4,540,000 | 0.94% | ||
| 28 | Sio Capital Management, LLC | 372,043 | 4,472,000 | 0.93% | ||
| 29 | RUSSELL FRANK CO/ | 355,137 | 4,411,000 | 0.92% | ||
| 30 | Cupps Capital Management, LLC | 340,416 | 4,091,000 | 0.85% | ||
| 31 | Tekla Capital Management LLC | 283,411 | 3,407,000 | 0.71% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 278,621 | 3,349,000 | 0.70% | ||
| 33 | Grandeur Peak Global Advisors, LLC | 252,756 | 3,038,000 | 0.63% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 241,893 | 2,907,000 | 0.60% | ||
| 35 | BLAIR WILLIAM & CO/IL | 234,065 | 2,813,000 | 0.58% | ||
| 36 | BAILARD, INC. | 232,000 | 2,789,000 | 0.58% | ||
| 37 | SUFFOLK CAPITAL MANAGEMENT LLC | 216,000 | 2,596,000 | 0.54% | ||
| 38 | SOPHROSYNE CAPITAL LLC | 211,619 | 2,542,000 | 0.53% | ||
| 39 | BAKER BROS. ADVISORS LP | 210,021 | 2,524,000 | 0.52% | ||
| 40 | AMERIPRISE FINANCIAL INC | 196,117 | 2,357,000 | 0.49% | ||
| 41 | Informed Momentum Co LLC | 175,791 | 2,113,000 | 0.44% | ||
| 42 | Ghost Tree Capital, LLC | 175,000 | 2,104,000 | 0.44% | ||
| 43 | AQR CAPITAL MANAGEMENT LLC | 172,300 | 2,071,000 | 0.43% | ||
| 44 | Foresite Capital Management II, LLC | 170,000 | 2,043,000 | 0.42% | Call | |
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 146,630 | 2,037,000 | 0.42% | ||
| 46 | Candriam S.C.A. | 160,000 | 1,923,000 | 0.40% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 156,900 | 1,886,000 | 0.39% | Call | |
| 48 | DENVER INVESTMENT ADVISORS LLC | 151,490 | 1,821,000 | 0.38% | ||
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 144,121 | 1,732,000 | 0.36% | ||
| 50 | Granahan Investment Management, LLC | 141,365 | 1,699,000 | 0.35% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
