| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 4,744,060 | 26,377,000 | 9.84% | ||
| 2 | STATE STREET CORP | 3,483,611 | 19,369,000 | 7.23% | ||
| 3 | EverPoint Asset Management, LLC | 2,735,585 | 15,210,000 | 5.68% | ||
| 4 | FEDERATED HERMES, INC. | 2,455,834 | 13,654,000 | 5.09% | ||
| 5 | VANGUARD GROUP INC | 1,753,406 | 9,749,000 | 3.64% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 1,715,900 | 9,540,000 | 3.56% | ||
| 7 | ARMISTICE CAPITAL, LLC | 1,480,000 | 8,229,000 | 3.07% | ||
| 8 | ROYCE & ASSOCIATES LP | 1,400,600 | 7,787,000 | 2.91% | ||
| 9 | Penn Capital Management Company, LLC | 1,230,592 | 6,842,000 | 2.55% | ||
| 10 | BlackRock Fund Advisors | 1,201,893 | 6,683,000 | 2.49% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,200,520 | 6,675,000 | 2.49% | ||
| 12 | VOYA INVESTMENT MANAGEMENT LLC | 952,107 | 5,294,000 | 1.98% | ||
| 13 | Foresite Capital Management II, LLC | 881,562 | 4,901,000 | 1.83% | ||
| 14 | DRIEHAUS CAPITAL MANAGEMENT LLC | 842,325 | 4,683,000 | 1.75% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 821,797 | 4,569,000 | 1.70% | ||
| 16 | ALPS ADVISORS INC | 82,025 | 4,561,000 | 1.70% | ||
| 17 | BANK OF MONTREAL /CAN/ | 800,218 | 4,449,000 | 1.66% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 711,300 | 3,955,000 | 1.48% | Call | |
| 19 | DEERFIELD MANAGEMENT COMPANY, L.P. | 700,000 | 3,892,000 | 1.45% | ||
| 20 | BLAIR WILLIAM & CO/IL | 686,223 | 3,815,000 | 1.42% | ||
| 21 | RUSSELL FRANK CO/ | 685,779 | 3,813,000 | 1.42% | ||
| 22 | Grandeur Peak Global Advisors, LLC | 636,331 | 3,538,000 | 1.32% | ||
| 23 | FMR LLC | 612,456 | 3,405,000 | 1.27% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 591,100 | 3,287,000 | 1.23% | Put | |
| 25 | TURNER INVESTMENTS LLC | 579,540 | 3,222,000 | 1.20% | ||
| 26 | TIVERTON ASSET MANAGEMENT LLC | 550,000 | 3,058,000 | 1.14% | ||
| 27 | NORTHERN TRUST CORP | 549,191 | 3,054,000 | 1.14% | ||
| 28 | BALYASNY ASSET MANAGEMENT L.P. | 540,416 | 3,005,000 | 1.12% | ||
| 29 | EverPoint Asset Management, LLC | 500,000 | 2,780,000 | 1.04% | Call | |
| 30 | 1492 Capital Management LLC | 497,469 | 2,766,000 | 1.03% | ||
| 31 | Foresite Capital Management I, LLC | 494,468 | 2,749,000 | 1.03% | ||
| 32 | FALCON POINT CAPITAL, LLC | 485,058 | 2,697,000 | 1.01% | ||
| 33 | NEW YORK STATE COMMON RETIREMENT FUND | 460,608 | 2,561,000 | 0.96% | ||
| 34 | GOLDMAN SACHS GROUP INC | 456,557 | 2,538,000 | 0.95% | ||
| 35 | Granahan Investment Management, LLC | 399,565 | 2,222,000 | 0.83% | ||
| 36 | SABBY MANAGEMENT, LLC | 368,641 | 2,050,000 | 0.76% | ||
| 37 | BAILARD, INC. | 360,000 | 2,002,000 | 0.75% | ||
| 38 | JPMORGAN CHASE & CO | 318,294 | 1,770,000 | 0.66% | ||
| 39 | Foresite Capital Management II, LLC | 310,000 | 1,724,000 | 0.64% | Put | |
| 40 | Foresite Capital Management II, LLC | 310,000 | 1,724,000 | 0.64% | Call | |
| 41 | Bank of New York Mellon Corp | 294,925 | 1,640,000 | 0.61% | ||
| 42 | SHEPHERD KAPLAN KROCHUK, LLC | 292,330 | 1,625,000 | 0.61% | ||
| 43 | GEODE CAPITAL MANAGEMENT, LLC | 290,605 | 1,615,000 | 0.60% | ||
| 44 | PYRRHO CAPITAL MANAGEMENT, LP | 277,422 | 1,542,000 | 0.58% | ||
| 45 | Tekla Capital Management LLC | 250,000 | 1,390,000 | 0.52% | ||
| 46 | Broadfin Capital, LLC | 250,000 | 1,390,000 | 0.52% | Call | |
| 47 | KENNEDY CAPITAL MANAGEMENT LLC | 229,160 | 1,274,000 | 0.48% | ||
| 48 | ACUTA CAPITAL PARTNERS, LLC | 212,100 | 1,179,000 | 0.44% | ||
| 49 | BAKER BROS. ADVISORS LP | 210,021 | 1,168,000 | 0.44% | ||
| 50 | Candriam S.C.A. | 208,600 | 1,160,000 | 0.43% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
