| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 12,757,842 | 22,709,000 | 24.15% | ||
| 2 | Broadfin Capital, LLC | 8,066,000 | 14,357,000 | 15.27% | ||
| 3 | DAFNA Capital Management LLC | 5,698,739 | 10,144,000 | 10.79% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,659,700 | 6,514,000 | 6.93% | ||
| 5 | BAKER BROS. ADVISORS LP | 3,652,117 | 6,501,000 | 6.91% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 2,363,914 | 4,208,000 | 4.48% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 2,144,485 | 3,817,000 | 4.06% | ||
| 8 | VANGUARD GROUP INC | 2,003,276 | 3,566,000 | 3.79% | ||
| 9 | Alyeska Investment Group, L.P. | 1,956,841 | 3,483,000 | 3.70% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,750,000 | 3,115,000 | 3.31% | ||
| 11 | Tamarack Capital Management, LLC | 1,500,000 | 2,775,000 | 2.95% | ||
| 12 | DEUTSCHE BANK AG\ | 925,892 | 1,647,000 | 1.75% | ||
| 13 | NORTHPOINTE CAPITAL LLC | 750,935 | 1,337,000 | 1.42% | ||
| 14 | TURNER INVESTMENTS LLC | 523,020 | 931,000 | 0.99% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 500,000 | 890,000 | 0.95% | ||
| 16 | Index Management Solutions, LLC | 456,398 | 812,000 | 0.86% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 438,635 | 780,000 | 0.83% | ||
| 18 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 416,500 | 741,000 | 0.79% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 391,218 | 697,000 | 0.74% | ||
| 20 | D. E. Shaw & Co., Inc. | 334,454 | 595,000 | 0.63% | ||
| 21 | SABBY MANAGEMENT, LLC | 315,661 | 562,000 | 0.60% | ||
| 22 | BlackRock Fund Advisors | 261,975 | 466,000 | 0.50% | ||
| 23 | NORTHERN TRUST CORP | 183,813 | 326,000 | 0.35% | ||
| 24 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 169,473 | 302,000 | 0.32% | ||
| 25 | GOLDMAN SACHS GROUP INC | 138,201 | 246,000 | 0.26% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 131,200 | 234,000 | 0.25% | Put | |
| 27 | MARSHALL WACE, LLP | 128,518 | 229,000 | 0.24% | ||
| 28 | GROUP ONE TRADING LLC | 119,279 | 212,000 | 0.23% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 94,100 | 167,000 | 0.18% | Call | |
| 30 | JANE STREET GROUP, LLC | 91,029 | 162,000 | 0.17% | ||
| 31 | TFS CAPITAL LLC | 86,562 | 154,000 | 0.16% | ||
| 32 | Bank of New York Mellon Corp | 65,771 | 117,000 | 0.12% | ||
| 33 | STATE STREET CORP | 57,285 | 102,000 | 0.11% | ||
| 34 | FRANKLIN STREET ADVISORS INC /NC | 46,500 | 83,000 | 0.09% | ||
| 35 | Pine River Capital Management L.P. | 200,000 | 77,000 | 0.08% | ||
| 36 | BRAVE ASSET MANAGEMENT INC | 43,500 | 77,000 | 0.08% | ||
| 37 | Commonwealth Equity Services, Inc | 40,333 | 72,000 | 0.08% | ||
| 38 | GUGGENHEIM CAPITAL LLC | 38,847 | 69,000 | 0.07% | ||
| 39 | CREDIT SUISSE AG/ | 31,977 | 57,000 | 0.06% | ||
| 40 | Rotella Capital Management, Inc. | 31,545 | 56,000 | 0.06% | ||
| 41 | UBS AG | 26,400 | 47,000 | 0.05% | Put | |
| 42 | DIMENSIONAL FUND ADVISORS LP | 26,472 | 47,000 | 0.05% | ||
| 43 | Wellington Shields Capital Management, LLC | 25,000 | 44,000 | 0.05% | ||
| 44 | CAPITAL MANAGEMENT ASSOCIATES /NY/ | 25,000 | 44,000 | 0.05% | ||
| 45 | BLACKROCK ADVISORS LLC | 22,340 | 40,000 | 0.04% | ||
| 46 | Spot Trading L.L.C | 22,124 | 39,000 | 0.04% | ||
| 47 | PRICE T ROWE ASSOCIATES INC /MD/ | 22,126 | 39,000 | 0.04% | ||
| 48 | REGIONS FINANCIAL CORP | 20,000 | 36,000 | 0.04% | ||
| 49 | STIFEL FINANCIAL CORP | 19,000 | 34,000 | 0.04% | ||
| 50 | MORGAN STANLEY | 16,150 | 29,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
