| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 12,780,992 | 23,517,000 | 24.78% | ||
| 2 | Broadfin Capital, LLC | 8,066,000 | 14,841,000 | 15.64% | ||
| 3 | DAFNA Capital Management LLC | 5,698,739 | 10,486,000 | 11.05% | SH | |
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,659,700 | 6,734,000 | 7.10% | ||
| 5 | BAKER BROS. ADVISORS LP | 3,652,117 | 6,720,000 | 7.08% | ||
| 6 | TURNER INVESTMENTS LLC | 2,798,860 | 5,150,000 | 5.43% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 2,515,058 | 4,628,000 | 4.88% | ||
| 8 | VANGUARD GROUP INC | 2,252,698 | 4,145,000 | 4.37% | ||
| 9 | Alyeska Investment Group, L.P. | 1,868,471 | 3,438,000 | 3.62% | ||
| 10 | Tamarack Capital Management, LLC | 1,500,000 | 2,760,000 | 2.91% | ||
| 11 | DEUTSCHE BANK AG\ | 1,335,068 | 2,455,000 | 2.59% | ||
| 12 | WELLINGTON MANAGEMENT GROUP LLP | 797,412 | 1,467,000 | 1.55% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 726,697 | 1,337,000 | 1.41% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 485,500 | 893,000 | 0.94% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 454,023 | 835,000 | 0.88% | ||
| 16 | NORTHPOINTE CAPITAL LLC | 334,435 | 615,000 | 0.65% | ||
| 17 | D. E. Shaw & Co., Inc. | 305,802 | 562,000 | 0.59% | ||
| 18 | BlackRock Fund Advisors | 244,227 | 449,000 | 0.47% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 198,100 | 365,000 | 0.38% | Put | |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 181,104 | 333,000 | 0.35% | ||
| 21 | BCWM, LLC | 18,000 | 332,000 | 0.35% | ||
| 22 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 169,473 | 312,000 | 0.33% | ||
| 23 | NORTHERN TRUST CORP | 160,435 | 295,000 | 0.31% | ||
| 24 | GOLDMAN SACHS GROUP INC | 138,090 | 254,000 | 0.27% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 114,100 | 210,000 | 0.22% | Call | |
| 26 | Nicholas Investment Partners, LP | 102,762 | 189,000 | 0.20% | ||
| 27 | GROUP ONE TRADING LLC | 78,943 | 145,000 | 0.15% | ||
| 28 | Bank of New York Mellon Corp | 65,771 | 121,000 | 0.13% | ||
| 29 | SABBY MANAGEMENT, LLC | 65,000 | 120,000 | 0.13% | ||
| 30 | STATE STREET CORP | 57,285 | 104,000 | 0.11% | ||
| 31 | Pine River Capital Management L.P. | 200,000 | 85,000 | 0.09% | ||
| 32 | FRANKLIN STREET ADVISORS INC /NC | 45,000 | 83,000 | 0.09% | ||
| 33 | BRAVE ASSET MANAGEMENT INC | 43,500 | 80,000 | 0.08% | ||
| 34 | Commonwealth Equity Services, Inc | 40,333 | 74,000 | 0.08% | ||
| 35 | PRICE T ROWE ASSOCIATES INC /MD/ | 36,126 | 66,000 | 0.07% | ||
| 36 | TFS CAPITAL LLC | 33,623 | 62,000 | 0.07% | ||
| 37 | DIMENSIONAL FUND ADVISORS LP | 26,472 | 49,000 | 0.05% | ||
| 38 | Wellington Shields Capital Management, LLC | 25,000 | 46,000 | 0.05% | ||
| 39 | CITADEL ADVISORS LLC | 24,510 | 45,000 | 0.05% | ||
| 40 | Rotella Capital Management, Inc. | 23,661 | 44,000 | 0.05% | ||
| 41 | UBS AG | 23,700 | 44,000 | 0.05% | Put | |
| 42 | BLACKROCK ADVISORS LLC | 22,340 | 41,000 | 0.04% | ||
| 43 | JANE STREET GROUP, LLC | 22,394 | 41,000 | 0.04% | ||
| 44 | First Allied Advisory Services, Inc. | 20,500 | 38,000 | 0.04% | ||
| 45 | REGIONS FINANCIAL CORP | 20,000 | 37,000 | 0.04% | ||
| 46 | STIFEL FINANCIAL CORP | 17,300 | 32,000 | 0.03% | ||
| 47 | UBS AG | 16,340 | 30,000 | 0.03% | ||
| 48 | Pinnacle Advisory Group, Inc. | 15,786 | 29,000 | 0.03% | ||
| 49 | Spot Trading L.L.C | 15,576 | 29,000 | 0.03% | ||
| 50 | MORGAN STANLEY | 15,865 | 29,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
