| 1 |
FMR LLC |
12,813,209 |
8,713,000 |
28.23% |
|
|
| 2 |
Broadfin Capital, LLC |
7,822,500 |
5,319,000 |
17.24% |
|
|
| 3 |
DAFNA Capital Management LLC |
4,794,874 |
3,261,000 |
10.57% |
|
SH |
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,659,700 |
2,489,000 |
8.07% |
|
|
| 5 |
BAKER BROS. ADVISORS LP |
3,569,643 |
2,427,000 |
7.86% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
2,625,453 |
1,785,000 |
5.78% |
|
|
| 7 |
VANGUARD GROUP INC |
2,523,454 |
1,716,000 |
5.56% |
|
|
| 8 |
TURNER INVESTMENTS LLC |
2,289,496 |
1,557,000 |
5.05% |
|
|
| 9 |
Alyeska Investment Group, L.P. |
1,102,107 |
749,000 |
2.43% |
|
|
| 10 |
MILLENNIUM MANAGEMENT LLC |
1,026,596 |
698,000 |
2.26% |
|
|
| 11 |
DEUTSCHE BANK AG\ |
606,758 |
412,000 |
1.34% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
456,410 |
310,000 |
1.00% |
|
|
| 13 |
D. E. Shaw & Co., Inc. |
316,425 |
215,000 |
0.70% |
|
|
| 14 |
GROUP ONE TRADING LLC |
223,047 |
152,000 |
0.49% |
|
|
| 15 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
169,473 |
115,000 |
0.37% |
|
|
| 16 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
159,600 |
109,000 |
0.35% |
Call |
|
| 17 |
OXFORD ASSET MANAGEMENT LLP |
147,055 |
100,000 |
0.32% |
|
|
| 18 |
SEARLE & CO. |
138,500 |
94,000 |
0.30% |
|
|
| 19 |
NORTHERN TRUST CORP |
120,369 |
81,000 |
0.26% |
|
|
| 20 |
MORGAN STANLEY |
111,688 |
76,000 |
0.25% |
|
|
| 21 |
Virtu KCG Holdings LLC |
105,494 |
72,000 |
0.23% |
|
|
| 22 |
Bank of New York Mellon Corp |
81,816 |
56,000 |
0.18% |
|
|
| 23 |
GOLDMAN SACHS GROUP INC |
69,141 |
47,000 |
0.15% |
|
|
| 24 |
STATE STREET CORP |
51,385 |
35,000 |
0.11% |
|
|
| 25 |
BANK OF AMERICA CORP /DE/ |
47,100 |
32,000 |
0.10% |
Call |
|
| 26 |
PRICE T ROWE ASSOCIATES INC /MD/ |
42,126 |
29,000 |
0.09% |
|
|
| 27 |
BRAVE ASSET MANAGEMENT INC |
41,500 |
28,000 |
0.09% |
|
|
| 28 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
40,440 |
27,000 |
0.09% |
|
|
| 29 |
Wellington Shields Capital Management, LLC |
25,000 |
17,000 |
0.06% |
|
|
| 30 |
Spark Investment Management LLC |
26,300 |
17,000 |
0.06% |
|
|
| 31 |
Pinnacle Advisory Group, Inc. |
24,938 |
16,000 |
0.05% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
22,340 |
15,000 |
0.05% |
|
|
| 33 |
Commonwealth Equity Services, Inc |
20,833 |
14,000 |
0.05% |
|
|
| 34 |
REGIONS FINANCIAL CORP |
20,000 |
14,000 |
0.05% |
|
|
| 35 |
STIFEL FINANCIAL CORP |
17,500 |
12,000 |
0.04% |
|
|
| 36 |
LPL Financial LLC |
15,566 |
10,000 |
0.03% |
|
|
| 37 |
UBS Group AG |
13,866 |
9,000 |
0.03% |
|
|
| 38 |
WELLS FARGO & COMPANY/MN |
12,526 |
9,000 |
0.03% |
|
|
| 39 |
GUGGENHEIM CAPITAL LLC |
11,525 |
8,000 |
0.03% |
|
|
| 40 |
Gradient Investments LLC |
10,000 |
7,000 |
0.02% |
|
|
| 41 |
CITIGROUP INC |
3,570 |
2,000 |
0.01% |
|
|
| 42 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
2,013 |
1,000 |
0.00% |
|
|
| 43 |
BANK OF AMERICA CORP /DE/ |
1,140 |
1,000 |
0.00% |
|
|
| 44 |
DEUTSCHE BANK AG\ |
1,500 |
1,000 |
0.00% |
Call |
|
| 45 |
CITADEL ADVISORS LLC |
1,327 |
1,000 |
0.00% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
849 |
577 |
0.00% |
|
|
| 47 |
MassMutual Private Wealth & Trust, FSB |
284 |
506 |
0.00% |
|
|
| 48 |
BANK OF MONTREAL /CAN/ |
86 |
0 |
0.00% |
|
|
| 49 |
ROYAL BANK OF CANADA |
400 |
0 |
0.00% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
416 |
0 |
0.00% |
|
|
