| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 12,800,619 | 15,233,000 | 25.21% | ||
| 2 | Broadfin Capital, LLC | 8,072,500 | 9,606,000 | 15.90% | ||
| 3 | DAFNA Capital Management LLC | 4,829,874 | 5,748,000 | 9.51% | SH | |
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,659,700 | 4,355,000 | 7.21% | ||
| 5 | BAKER BROS. ADVISORS LP | 3,569,643 | 4,248,000 | 7.03% | ||
| 6 | TURNER INVESTMENTS LLC | 3,541,759 | 4,215,000 | 6.98% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 2,584,019 | 3,075,000 | 5.09% | ||
| 8 | Ghost Tree Capital, LLC | 2,500,000 | 2,975,000 | 4.92% | ||
| 9 | VANGUARD GROUP INC | 2,400,728 | 2,857,000 | 4.73% | ||
| 10 | Alyeska Investment Group, L.P. | 1,391,486 | 1,656,000 | 2.74% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 1,000,000 | 1,190,000 | 1.97% | ||
| 12 | DEUTSCHE BANK AG\ | 816,858 | 971,000 | 1.61% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 456,069 | 542,000 | 0.90% | ||
| 14 | ACUTA CAPITAL PARTNERS, LLC | 393,148 | 468,000 | 0.77% | ||
| 15 | MORGAN STANLEY | 323,998 | 386,000 | 0.64% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 311,100 | 370,000 | 0.61% | Call | |
| 17 | BlackRock Fund Advisors | 246,315 | 293,000 | 0.48% | ||
| 18 | Tamarack Capital Management, LLC | 235,542 | 280,000 | 0.46% | ||
| 19 | D. E. Shaw & Co., Inc. | 197,061 | 235,000 | 0.39% | ||
| 20 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 169,473 | 234,000 | 0.39% | ||
| 21 | NORTHERN TRUST CORP | 160,157 | 191,000 | 0.32% | ||
| 22 | SEARLE & CO. | 138,500 | 164,000 | 0.27% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 117,600 | 140,000 | 0.23% | Call | |
| 24 | GOLDMAN SACHS GROUP INC | 74,555 | 89,000 | 0.15% | ||
| 25 | OXFORD ASSET MANAGEMENT LLP | 68,851 | 82,000 | 0.14% | ||
| 26 | Bank of New York Mellon Corp | 65,771 | 78,000 | 0.13% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,500 | 65,000 | 0.11% | Put | |
| 28 | Spot Trading L.L.C | 53,300 | 63,000 | 0.10% | Call | |
| 29 | STATE STREET CORP | 51,385 | 61,000 | 0.10% | ||
| 30 | BRAVE ASSET MANAGEMENT INC | 41,500 | 49,000 | 0.08% | ||
| 31 | Virtu KCG Holdings LLC | 39,649 | 47,000 | 0.08% | ||
| 32 | PRICE T ROWE ASSOCIATES INC /MD/ | 36,126 | 43,000 | 0.07% | ||
| 33 | JPMORGAN CHASE & CO | 35,392 | 42,000 | 0.07% | ||
| 34 | CREDIT SUISSE AG/ | 30,650 | 36,000 | 0.06% | ||
| 35 | Wellington Shields Capital Management, LLC | 25,000 | 30,000 | 0.05% | ||
| 36 | BLACKROCK ADVISORS LLC | 22,340 | 27,000 | 0.04% | ||
| 37 | Pinnacle Advisory Group, Inc. | 22,102 | 26,000 | 0.04% | ||
| 38 | Commonwealth Equity Services, Inc | 20,833 | 25,000 | 0.04% | ||
| 39 | REGIONS FINANCIAL CORP | 20,000 | 24,000 | 0.04% | ||
| 40 | Rotella Capital Management, Inc. | 19,516 | 23,000 | 0.04% | ||
| 41 | UBS Group AG | 18,009 | 22,000 | 0.04% | ||
| 42 | STIFEL FINANCIAL CORP | 14,800 | 18,000 | 0.03% | ||
| 43 | CITADEL ADVISORS LLC | 15,364 | 18,000 | 0.03% | ||
| 44 | BlackRock Investment Management, LLC | 14,353 | 17,000 | 0.03% | ||
| 45 | SIMPLEX TRADING, LLC | 13,912 | 16,000 | 0.03% | ||
| 46 | TWO SIGMA SECURITIES, LLC | 13,825 | 16,000 | 0.03% | ||
| 47 | GUGGENHEIM CAPITAL LLC | 11,525 | 14,000 | 0.02% | ||
| 48 | WELLS FARGO & COMPANY/MN | 10,220 | 12,000 | 0.02% | ||
| 49 | Spot Trading L.L.C | 7,246 | 9,000 | 0.01% | ||
| 50 | Pine River Capital Management L.P. | 200,000 | 8,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
