| 1 |
FMR LLC |
12,893,009 |
3,868,000 |
19.79% |
|
|
| 2 |
Broadfin Capital, LLC |
9,489,166 |
2,847,000 |
14.56% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
8,537,995 |
2,561,000 |
13.10% |
|
|
| 4 |
DAFNA Capital Management LLC |
7,508,544 |
2,253,000 |
11.52% |
|
SH |
| 5 |
SABBY MANAGEMENT, LLC |
4,703,551 |
1,411,000 |
7.22% |
|
|
| 6 |
Alyeska Investment Group, L.P. |
3,858,507 |
1,158,000 |
5.92% |
|
|
| 7 |
BAKER BROS. ADVISORS LP |
3,569,643 |
1,071,000 |
5.48% |
|
|
| 8 |
BlackRock Institutional Trust Company, N.A. |
2,661,535 |
798,000 |
4.08% |
|
|
| 9 |
VANGUARD GROUP INC |
2,537,184 |
761,000 |
3.89% |
|
|
| 10 |
GREAT POINT PARTNERS LLC |
2,530,532 |
759,000 |
3.88% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
2,500,000 |
750,000 |
3.84% |
Call |
|
| 12 |
MILLENNIUM MANAGEMENT LLC |
1,258,920 |
378,000 |
1.93% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
763,107 |
228,000 |
1.17% |
|
|
| 14 |
DEUTSCHE BANK AG\ |
606,758 |
182,000 |
0.93% |
|
|
| 15 |
D. E. Shaw & Co., Inc. |
316,442 |
95,000 |
0.49% |
|
|
| 16 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
169,473 |
51,000 |
0.26% |
|
|
| 17 |
MORGAN STANLEY |
155,768 |
47,000 |
0.24% |
|
|
| 18 |
SEARLE & CO. |
138,500 |
42,000 |
0.21% |
|
|
| 19 |
GROUP ONE TRADING LLC |
139,277 |
42,000 |
0.21% |
|
|
| 20 |
NORTHERN TRUST CORP |
135,848 |
41,000 |
0.21% |
|
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
82,700 |
25,000 |
0.13% |
Call |
|
| 22 |
Bank of New York Mellon Corp |
81,772 |
25,000 |
0.13% |
|
|
| 23 |
GOLDMAN SACHS GROUP INC |
57,430 |
17,000 |
0.09% |
|
|
| 24 |
STATE STREET CORP |
51,385 |
15,000 |
0.08% |
|
|
| 25 |
BANK OF AMERICA CORP /DE/ |
47,100 |
14,000 |
0.07% |
Call |
|
| 26 |
PRICE T ROWE ASSOCIATES INC /MD/ |
42,126 |
13,000 |
0.07% |
|
|
| 27 |
BLACKROCK ADVISORS LLC |
39,288 |
12,000 |
0.06% |
|
|
| 28 |
WEDBUSH SECURITIES INC |
35,804 |
11,000 |
0.06% |
|
|
| 29 |
BRAVE ASSET MANAGEMENT INC |
32,500 |
10,000 |
0.05% |
|
|
| 30 |
UBS Group AG |
28,242 |
9,000 |
0.05% |
|
|
| 31 |
Pinnacle Advisory Group, Inc. |
29,902 |
8,000 |
0.04% |
|
|
| 32 |
Wellington Shields Capital Management, LLC |
25,000 |
7,000 |
0.04% |
|
|
| 33 |
STIFEL FINANCIAL CORP |
19,000 |
6,000 |
0.03% |
|
|
| 34 |
REGIONS FINANCIAL CORP |
20,000 |
6,000 |
0.03% |
|
|
| 35 |
Commonwealth Equity Services, Inc |
20,833 |
6,000 |
0.03% |
|
|
| 36 |
LPL Financial LLC |
15,566 |
5,000 |
0.03% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
12,526 |
4,000 |
0.02% |
|
|
| 38 |
Virtu KCG Holdings LLC |
13,538 |
4,000 |
0.02% |
|
|
| 39 |
GUGGENHEIM CAPITAL LLC |
13,170 |
4,000 |
0.02% |
|
|
| 40 |
Gradient Investments LLC |
10,000 |
3,000 |
0.02% |
|
|
| 41 |
CITIGROUP INC |
2,700 |
1,000 |
0.01% |
|
|
| 42 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
2,013 |
1,000 |
0.01% |
|
|
| 43 |
MassMutual Private Wealth & Trust, FSB |
284 |
523 |
0.00% |
|
|
| 44 |
TURNER INVESTMENTS LLC |
0 |
0 |
0.00% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
416 |
0 |
0.00% |
|
|
| 46 |
DEUTSCHE BANK AG\ |
1,500 |
0 |
0.00% |
Call |
|
| 47 |
BANK OF AMERICA CORP /DE/ |
1,068 |
0 |
0.00% |
|
|
| 48 |
Creative Planning |
66 |
0 |
0.00% |
|
|
| 49 |
Pine River Capital Management L.P. |
200,000 |
0 |
0.00% |
|
|
| 50 |
ROYAL BANK OF CANADA |
400 |
0 |
0.00% |
|
|
