| 1 |
FMR LLC |
12,800,619 |
14,848,000 |
24.95% |
|
|
| 2 |
Broadfin Capital, LLC |
8,066,000 |
9,357,000 |
15.72% |
|
|
| 3 |
DAFNA Capital Management LLC |
5,698,739 |
6,611,000 |
11.11% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,659,700 |
4,245,000 |
7.13% |
|
|
| 5 |
BAKER BROS. ADVISORS LP |
3,652,117 |
4,236,000 |
7.12% |
|
|
| 6 |
TURNER INVESTMENTS LLC |
3,026,322 |
3,511,000 |
5.90% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
2,521,375 |
2,925,000 |
4.92% |
|
|
| 8 |
VANGUARD GROUP INC |
2,304,298 |
2,673,000 |
4.49% |
|
|
| 9 |
Alyeska Investment Group, L.P. |
1,705,312 |
1,978,000 |
3.32% |
|
|
| 10 |
Tamarack Capital Management, LLC |
1,500,000 |
1,740,000 |
2.92% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
1,325,000 |
1,537,000 |
2.58% |
|
|
| 12 |
DEUTSCHE BANK AG\ |
1,243,211 |
1,441,000 |
2.42% |
|
|
| 13 |
WELLINGTON MANAGEMENT GROUP LLP |
722,592 |
838,000 |
1.41% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
455,046 |
527,000 |
0.89% |
|
|
| 15 |
BlackRock Fund Advisors |
263,019 |
305,000 |
0.51% |
|
|
| 16 |
D. E. Shaw & Co., Inc. |
240,175 |
279,000 |
0.47% |
|
|
| 17 |
MORGAN STANLEY |
235,274 |
273,000 |
0.46% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
217,800 |
253,000 |
0.43% |
Call |
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
169,473 |
234,000 |
0.39% |
|
|
| 20 |
NORTHERN TRUST CORP |
160,435 |
186,000 |
0.31% |
|
|
| 21 |
SEARLE & CO. |
148,500 |
172,000 |
0.29% |
|
|
| 22 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
117,402 |
136,000 |
0.23% |
|
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
114,200 |
132,000 |
0.22% |
Put |
|
| 24 |
GOLDMAN SACHS GROUP INC |
111,301 |
129,000 |
0.22% |
|
|
| 25 |
CREDIT SUISSE AG/ |
102,048 |
118,000 |
0.20% |
|
|
| 26 |
OXFORD ASSET MANAGEMENT LLP |
99,221 |
115,000 |
0.19% |
|
|
| 27 |
Bank of New York Mellon Corp |
65,771 |
76,000 |
0.13% |
|
|
| 28 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
59,790 |
69,000 |
0.12% |
|
|
| 29 |
STATE STREET CORP |
51,385 |
60,000 |
0.10% |
|
|
| 30 |
FRANKLIN STREET ADVISORS INC /NC |
45,000 |
52,000 |
0.09% |
|
|
| 31 |
BRAVE ASSET MANAGEMENT INC |
41,500 |
48,000 |
0.08% |
|
|
| 32 |
PRICE T ROWE ASSOCIATES INC /MD/ |
36,126 |
42,000 |
0.07% |
|
|
| 33 |
GROUP ONE TRADING LLC |
32,399 |
38,000 |
0.06% |
|
|
| 34 |
DIMENSIONAL FUND ADVISORS LP |
26,472 |
31,000 |
0.05% |
|
|
| 35 |
Wellington Shields Capital Management, LLC |
25,000 |
29,000 |
0.05% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
22,340 |
26,000 |
0.04% |
|
|
| 37 |
STIFEL FINANCIAL CORP |
22,800 |
26,000 |
0.04% |
|
|
| 38 |
CITADEL ADVISORS LLC |
20,797 |
24,000 |
0.04% |
|
|
| 39 |
First Allied Advisory Services, Inc. |
20,500 |
24,000 |
0.04% |
|
|
| 40 |
REGIONS FINANCIAL CORP |
20,000 |
23,000 |
0.04% |
|
|
| 41 |
Pinnacle Advisory Group, Inc. |
18,330 |
21,000 |
0.04% |
|
|
| 42 |
Alpine Global Management, LLC |
18,437 |
21,000 |
0.04% |
|
|
| 43 |
BlackRock Investment Management, LLC |
14,256 |
17,000 |
0.03% |
|
|
| 44 |
UBS Group AG |
14,082 |
16,000 |
0.03% |
|
|
| 45 |
Rotella Capital Management, Inc. |
12,116 |
14,000 |
0.02% |
|
|
| 46 |
GUGGENHEIM CAPITAL LLC |
11,473 |
13,000 |
0.02% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
9,816 |
11,000 |
0.02% |
|
|
| 48 |
DEUTSCHE BANK AG\ |
7,931 |
9,000 |
0.02% |
Call |
|
| 49 |
CITIGROUP INC |
6,706 |
8,000 |
0.01% |
|
|
| 50 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
5,013 |
6,000 |
0.01% |
|
|
