| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,003,208 | 86,278,000 | 20.55% | ||
| 2 | Consonance Capital Management LP | 1,546,097 | 66,590,000 | 15.86% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,539,586 | 66,310,000 | 15.80% | ||
| 4 | EAGLE ASSET MANAGEMENT INC | 802,359 | 34,557,000 | 8.23% | ||
| 5 | SENZAR ASSET MANAGEMENT, LLC | 255,128 | 10,988,000 | 2.62% | ||
| 6 | BlackRock Fund Advisors | 254,706 | 10,970,000 | 2.61% | ||
| 7 | GLENMEDE TRUST CO NA | 225,169 | 9,696,000 | 2.31% | ||
| 8 | WALL STREET ASSOCIATES | 219,200 | 9,441,000 | 2.25% | ||
| 9 | VANGUARD GROUP INC | 179,910 | 7,749,000 | 1.85% | ||
| 10 | INSIGHT CAPITAL RESEARCH & MANAGEMENT INC | 158,315 | 6,819,000 | 1.62% | ||
| 11 | CADENCE CAPITAL MANAGEMENT LLC | 132,973 | 5,727,000 | 1.36% | ||
| 12 | STATE STREET CORP | 122,797 | 5,288,000 | 1.26% | ||
| 13 | BENNETT LAWRENCE MANAGEMENT L L C/NY | 118,445 | 5,102,000 | 1.22% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 116,164 | 5,003,000 | 1.19% | ||
| 15 | TURNER INVESTMENTS LLC | 105,150 | 4,529,000 | 1.08% | ||
| 16 | Sarissa Capital Management LP | 105,000 | 4,522,000 | 1.08% | ||
| 17 | MANAGED ACCOUNT ADVISORS LLC | 92,172 | 3,970,000 | 0.95% | ||
| 18 | BAILARD, INC. | 91,500 | 3,941,000 | 0.94% | ||
| 19 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 82,413 | 3,550,000 | 0.85% | ||
| 20 | Invesco Ltd. | 75,501 | 3,252,000 | 0.77% | ||
| 21 | BAKER BROS. ADVISORS LP | 75,357 | 3,246,000 | 0.77% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 74,762 | 3,220,000 | 0.77% | ||
| 23 | BARCLAYS PLC | 68,888 | 2,962,000 | 0.71% | ||
| 24 | Informed Momentum Co LLC | 64,554 | 2,780,000 | 0.66% | ||
| 25 | NEW YORK STATE COMMON RETIREMENT FUND | 57,200 | 2,464,000 | 0.59% | ||
| 26 | Bank of New York Mellon Corp | 56,671 | 2,441,000 | 0.58% | ||
| 27 | NORTHERN TRUST CORP | 56,443 | 2,431,000 | 0.58% | ||
| 28 | Aureus Asset Management, LLC | 55,530 | 2,392,000 | 0.57% | ||
| 29 | RENAISSANCE TECHNOLOGIES LLC | 54,600 | 2,352,000 | 0.56% | ||
| 30 | ANALYTIC INVESTORS, LLC | 54,557 | 2,350,000 | 0.56% | ||
| 31 | Ghost Tree Capital, LLC | 50,000 | 2,154,000 | 0.51% | ||
| 32 | Allianz Asset Management GmbH | 46,615 | 2,008,000 | 0.48% | ||
| 33 | Apex Capital Management | 45,093 | 1,942,000 | 0.46% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 42,399 | 1,826,000 | 0.43% | ||
| 35 | BLACKROCK ADVISORS LLC | 42,004 | 1,809,000 | 0.43% | ||
| 36 | RUSSELL FRANK CO/ | 47,033 | 1,770,000 | 0.42% | ||
| 37 | Dai-ichi Life Holdings, Inc. | 34,145 | 1,471,000 | 0.35% | ||
| 38 | AMERIPRISE FINANCIAL INC | 32,247 | 1,389,000 | 0.33% | ||
| 39 | THRIVENT FINANCIAL FOR LUTHERANS | 30,731 | 1,324,000 | 0.32% | ||
| 40 | BlackRock Investment Management, LLC | 29,914 | 1,288,000 | 0.31% | ||
| 41 | DEUTSCHE BANK AG\ | 28,456 | 1,225,000 | 0.29% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,900 | 1,159,000 | 0.28% | Put | |
| 43 | WELLS FARGO & COMPANY/MN | 26,659 | 1,148,000 | 0.27% | ||
| 44 | PUTNAM INVESTMENTS LLC | 25,961 | 1,118,000 | 0.27% | ||
| 45 | Granite Point Capital Management, L.P. | 25,000 | 1,077,000 | 0.26% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 21,100 | 909,000 | 0.22% | Call | |
| 47 | AQR CAPITAL MANAGEMENT LLC | 20,900 | 900,000 | 0.21% | ||
| 48 | REGIONS FINANCIAL CORP | 19,535 | 841,000 | 0.20% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,843 | 812,000 | 0.19% | ||
| 50 | CREDIT SUISSE AG/ | 18,605 | 802,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
