| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,008,508 | 79,477,000 | 19.55% | ||
| 2 | Consonance Capital Management LP | 1,599,109 | 63,277,000 | 15.56% | ||
| 3 | EAGLE ASSET MANAGEMENT INC | 925,873 | 36,636,000 | 9.01% | ||
| 4 | SENZAR ASSET MANAGEMENT, LLC | 566,903 | 22,432,000 | 5.52% | ||
| 5 | GLENMEDE TRUST CO NA | 327,655 | 12,962,000 | 3.19% | ||
| 6 | MARSHALL WACE, LLP | 316,426 | 12,521,000 | 3.08% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 250,000 | 9,893,000 | 2.43% | ||
| 8 | BlackRock Fund Advisors | 249,249 | 9,863,000 | 2.43% | ||
| 9 | VANGUARD GROUP INC | 242,260 | 9,587,000 | 2.36% | ||
| 10 | GUGGENHEIM CAPITAL LLC | 205,388 | 8,128,000 | 2.00% | ||
| 11 | WALL STREET ASSOCIATES | 159,100 | 6,296,000 | 1.55% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 152,550 | 6,036,000 | 1.48% | ||
| 13 | INSIGHT CAPITAL RESEARCH & MANAGEMENT INC | 136,637 | 5,407,000 | 1.33% | ||
| 14 | STATE STREET CORP | 124,697 | 4,935,000 | 1.21% | ||
| 15 | NORTHERN TRUST CORP | 121,322 | 4,800,000 | 1.18% | ||
| 16 | Numeric Investors LLC | 111,200 | 4,400,000 | 1.08% | ||
| 17 | BENNETT LAWRENCE MANAGEMENT L L C/NY | 110,515 | 4,373,000 | 1.08% | ||
| 18 | MANAGED ACCOUNT ADVISORS LLC | 105,367 | 4,169,000 | 1.03% | ||
| 19 | Sarissa Capital Management LP | 105,000 | 4,155,000 | 1.02% | ||
| 20 | TFS CAPITAL LLC | 93,771 | 3,711,000 | 0.91% | ||
| 21 | BAILARD, INC. | 91,500 | 3,621,000 | 0.89% | ||
| 22 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 84,971 | 3,363,000 | 0.83% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 83,277 | 3,295,000 | 0.81% | ||
| 24 | DEUTSCHE BANK AG\ | 77,167 | 3,052,000 | 0.75% | ||
| 25 | Invesco Ltd. | 75,885 | 3,003,000 | 0.74% | ||
| 26 | BAKER BROS. ADVISORS LP | 75,357 | 2,982,000 | 0.73% | ||
| 27 | TURNER INVESTMENTS LLC | 75,110 | 2,972,000 | 0.73% | ||
| 28 | CADENCE CAPITAL MANAGEMENT LLC | 73,353 | 2,903,000 | 0.71% | ||
| 29 | BLACKROCK ADVISORS LLC | 70,230 | 2,779,000 | 0.68% | ||
| 30 | Bank of New York Mellon Corp | 67,217 | 2,659,000 | 0.65% | ||
| 31 | Informed Momentum Co LLC | 62,768 | 2,484,000 | 0.61% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 59,885 | 2,370,000 | 0.58% | ||
| 33 | AQR CAPITAL MANAGEMENT LLC | 59,200 | 2,343,000 | 0.58% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 56,813 | 2,248,000 | 0.55% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 55,719 | 2,204,000 | 0.54% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 54,834 | 2,170,000 | 0.53% | ||
| 37 | Gotham Asset Management, LLC | 52,230 | 2,067,000 | 0.51% | ||
| 38 | Apex Capital Management | 50,250 | 1,988,000 | 0.49% | ||
| 39 | GOLDMAN SACHS GROUP INC | 47,467 | 1,878,000 | 0.46% | ||
| 40 | CITADEL ADVISORS LLC | 46,554 | 1,841,000 | 0.45% | ||
| 41 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 45,813 | 1,813,000 | 0.45% | ||
| 42 | RUSSELL FRANK CO/ | 45,437 | 1,798,000 | 0.44% | ||
| 43 | ANALYTIC INVESTORS, LLC | 42,502 | 1,682,000 | 0.41% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 41,270 | 1,633,000 | 0.40% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,600 | 1,607,000 | 0.40% | Put | |
| 46 | BARCLAYS PLC | 38,348 | 1,495,000 | 0.37% | ||
| 47 | Spark Investment Management LLC | 35,800 | 1,416,000 | 0.35% | ||
| 48 | Ghost Tree Capital, LLC | 35,000 | 1,385,000 | 0.34% | ||
| 49 | Dai-ichi Life Holdings, Inc. | 33,508 | 1,326,000 | 0.33% | ||
| 50 | WEXFORD CAPITAL LP | 31,870 | 1,261,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
