| 1 |
FMR LLC |
2,467,708 |
98,684,000 |
29.26% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
1,541,078 |
61,628,000 |
18.27% |
|
|
| 3 |
Consonance Capital Management LP |
1,254,459 |
50,166,000 |
14.88% |
|
|
| 4 |
EAGLE ASSET MANAGEMENT INC |
529,343 |
21,168,000 |
6.28% |
|
|
| 5 |
WALL STREET ASSOCIATES |
216,600 |
8,662,000 |
2.57% |
|
|
| 6 |
INSIGHT CAPITAL RESEARCH & MANAGEMENT INC |
206,863 |
8,272,000 |
2.45% |
|
|
| 7 |
VANGUARD GROUP INC |
167,631 |
6,703,000 |
1.99% |
|
|
| 8 |
CADENCE CAPITAL MANAGEMENT LLC |
162,100 |
6,482,000 |
1.92% |
|
|
| 9 |
SENZAR ASSET MANAGEMENT, LLC |
141,128 |
5,644,000 |
1.67% |
|
|
| 10 |
TURNER INVESTMENTS LLC |
120,300 |
4,810,000 |
1.43% |
|
|
| 11 |
BlackRock Fund Advisors |
102,624 |
4,104,000 |
1.22% |
|
|
| 12 |
Bank of New York Mellon Corp |
88,691 |
3,547,000 |
1.05% |
|
|
| 13 |
BAKER BROS. ADVISORS LP |
80,957 |
3,237,000 |
0.96% |
|
|
| 14 |
BARCLAYS PLC |
80,459 |
3,138,000 |
0.93% |
|
|
| 15 |
BAILARD, INC. |
74,306 |
2,971,000 |
0.88% |
|
|
| 16 |
MANAGED ACCOUNT ADVISORS LLC |
74,135 |
2,964,000 |
0.88% |
|
|
| 17 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
72,546 |
2,901,000 |
0.86% |
|
|
| 18 |
Informed Momentum Co LLC |
65,846 |
2,633,000 |
0.78% |
|
|
| 19 |
QS BATTERYMARCH FINANCIAL MANAGEMENT, INC |
59,800 |
2,392,000 |
0.71% |
|
|
| 20 |
Hatteras Alternative Mutual Funds, LLC |
58,924 |
2,356,000 |
0.70% |
|
|
| 21 |
Granite Point Capital Management, L.P. |
55,000 |
2,199,000 |
0.65% |
|
|
| 22 |
WELLS FARGO & COMPANY/MN |
53,907 |
2,156,000 |
0.64% |
|
|
| 23 |
NORTHERN TRUST CORP |
51,239 |
2,049,000 |
0.61% |
|
|
| 24 |
Allianz Asset Management GmbH |
50,765 |
2,030,000 |
0.60% |
|
|
| 25 |
STATE STREET CORP |
50,644 |
2,026,000 |
0.60% |
|
|
| 26 |
Sarissa Capital Management LP |
50,000 |
2,000,000 |
0.59% |
|
|
| 27 |
BlackRock Institutional Trust Company, N.A. |
40,249 |
1,610,000 |
0.48% |
|
|
| 28 |
RUSSELL FRANK CO/ |
42,606 |
1,594,000 |
0.47% |
|
|
| 29 |
Apex Capital Management |
38,755 |
1,550,000 |
0.46% |
|
|
| 30 |
Ghost Tree Capital, LLC |
35,000 |
1,400,000 |
0.42% |
|
|
| 31 |
Dai-ichi Life Holdings, Inc. |
34,842 |
1,393,000 |
0.41% |
|
|
| 32 |
BENNETT LAWRENCE MANAGEMENT L L C/NY |
34,005 |
1,360,000 |
0.40% |
|
|
| 33 |
AMERIPRISE FINANCIAL INC |
30,352 |
1,214,000 |
0.36% |
|
|
| 34 |
GEODE CAPITAL MANAGEMENT, LLC |
29,943 |
1,197,000 |
0.35% |
|
|
| 35 |
PUTNAM INVESTMENTS LLC |
25,929 |
1,037,000 |
0.31% |
|
|
| 36 |
Invesco Ltd. |
25,562 |
1,022,000 |
0.30% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
18,795 |
751,000 |
0.22% |
|
|
| 38 |
ANALYTIC INVESTORS, LLC |
17,230 |
689,000 |
0.20% |
|
|
| 39 |
STRS OHIO |
16,600 |
664,000 |
0.20% |
|
|
| 40 |
Asset Management One Co., Ltd. |
13,500 |
525,000 |
0.16% |
|
|
| 41 |
Numeric Investors LLC |
12,200 |
488,000 |
0.14% |
|
|
| 42 |
Absolute Return Capital, LLC |
11,815 |
472,000 |
0.14% |
|
|
| 43 |
Connor, Clark & Lunn Investment Management Ltd. |
10,000 |
441,000 |
0.13% |
|
|
| 44 |
Nationwide Fund Advisors |
10,818 |
433,000 |
0.13% |
|
|
| 45 |
CREDIT SUISSE AG/ |
10,598 |
424,000 |
0.13% |
|
|
| 46 |
BlackRock Investment Management, LLC |
10,326 |
413,000 |
0.12% |
|
|
| 47 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
7,802 |
313,000 |
0.09% |
|
|
| 48 |
PNC FINANCIAL SERVICES GROUP, INC. |
6,997 |
280,000 |
0.08% |
|
|
| 49 |
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
6,670 |
266,733 |
0.08% |
|
|
| 50 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
6,543 |
262,000 |
0.08% |
|
|
