| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BlackRock Fund Advisors | 1,447,002 | 48,475,000 | 10.84% | ||
| 2 | Krensavage Asset Management, LLC | 1,055,719 | 35,367,000 | 7.91% | ||
| 3 | GREAT POINT PARTNERS LLC | 828,253 | 27,746,000 | 6.21% | ||
| 4 | VANGUARD GROUP INC | 739,158 | 24,761,000 | 5.54% | ||
| 5 | RENAISSANCE TECHNOLOGIES LLC | 574,771 | 19,255,000 | 4.31% | ||
| 6 | ACADIAN ASSET MANAGEMENT LLC | 568,686 | 19,049,000 | 4.26% | ||
| 7 | STATE STREET CORP | 568,238 | 19,036,000 | 4.26% | ||
| 8 | Granahan Investment Management, LLC | 496,025 | 16,617,000 | 3.72% | ||
| 9 | FIRST MANHATTAN CO. LLC. | 484,500 | 16,230,000 | 3.63% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 459,134 | 15,381,000 | 3.44% | ||
| 11 | FMR LLC | 391,815 | 13,126,000 | 2.94% | ||
| 12 | Matarin Capital Management, LLC | 257,268 | 8,618,478 | 1.93% | ||
| 13 | Candriam S.C.A. | 236,000 | 7,906,000 | 1.77% | ||
| 14 | STONEPINE CAPITAL MANAGEMENT, LLC | 231,913 | 7,769,000 | 1.74% | ||
| 15 | ARMISTICE CAPITAL, LLC | 228,000 | 7,638,000 | 1.71% | ||
| 16 | AJO, LP | 200,422 | 6,714,000 | 1.50% | ||
| 17 | Bank of New York Mellon Corp | 194,056 | 6,501,000 | 1.45% | ||
| 18 | Spark Investment Management LLC | 190,800 | 6,391,000 | 1.43% | ||
| 19 | NORTHERN TRUST CORP | 190,311 | 6,375,000 | 1.43% | ||
| 20 | DIMENSIONAL FUND ADVISORS LP | 179,824 | 6,024,000 | 1.35% | ||
| 21 | SEIZERT CAPITAL PARTNERS, LLC | 152,428 | 5,106,000 | 1.14% | ||
| 22 | OXFORD ASSET MANAGEMENT LLP | 142,669 | 4,779,000 | 1.07% | ||
| 23 | JPMORGAN CHASE & CO | 137,746 | 4,615,000 | 1.03% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 132,584 | 4,441,000 | 0.99% | ||
| 25 | ALLIANCEBERNSTEIN L.P. | 132,060 | 4,424,000 | 0.99% | ||
| 26 | HAYS ADVISORY LLC | 116,939 | 3,917,000 | 0.88% | ||
| 27 | McClain Value Management LLC | 116,153 | 3,891,000 | 0.87% | ||
| 28 | AQR CAPITAL MANAGEMENT LLC | 113,794 | 3,812,000 | 0.85% | ||
| 29 | AMERIPRISE FINANCIAL INC | 113,535 | 3,803,000 | 0.85% | ||
| 30 | Numeric Investors LLC | 108,800 | 3,645,000 | 0.82% | ||
| 31 | PRINCIPAL FINANCIAL GROUP INC | 102,525 | 3,435,000 | 0.77% | ||
| 32 | TWO SIGMA INVESTMENTS, LP | 95,196 | 3,189,000 | 0.71% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 94,774 | 3,175,000 | 0.71% | ||
| 34 | Opaleye Management Inc. | 90,000 | 3,015,000 | 0.67% | ||
| 35 | BlackRock Investment Management, LLC | 85,043 | 2,849,000 | 0.64% | ||
| 36 | PNC FINANCIAL SERVICES GROUP, INC. | 84,236 | 2,823,000 | 0.63% | ||
| 37 | GOLDMAN SACHS GROUP INC | 82,349 | 2,759,000 | 0.62% | ||
| 38 | QS Investors, LLC | 78,341 | 2,624,000 | 0.59% | ||
| 39 | GSA CAPITAL PARTNERS LLP | 77,309 | 2,590,000 | 0.58% | ||
| 40 | BAKER BROS. ADVISORS LP | 75,357 | 2,524,000 | 0.56% | ||
| 41 | DEUTSCHE BANK AG\ | 64,444 | 2,158,000 | 0.48% | ||
| 42 | Invesco Ltd. | 58,766 | 1,968,000 | 0.44% | ||
| 43 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 51,200 | 1,715,000 | 0.38% | ||
| 44 | Gotham Asset Management, LLC | 50,629 | 1,696,000 | 0.38% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 50,576 | 1,695,000 | 0.38% | ||
| 46 | CITIGROUP INC | 50,454 | 1,691,000 | 0.38% | ||
| 47 | MORGAN STANLEY | 50,260 | 1,683,000 | 0.38% | ||
| 48 | PRUDENTIAL FINANCIAL INC | 48,928 | 1,639,000 | 0.37% | ||
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 47,591 | 1,594,000 | 0.36% | ||
| 50 | WELLINGTON MANAGEMENT GROUP LLP | 42,878 | 1,437,000 | 0.32% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
