| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 5,345,600 | 141,231,000 | 9.72% | ||
| 2 | BlackRock Fund Advisors | 4,947,295 | 130,708,000 | 8.99% | ||
| 3 | VANGUARD GROUP INC | 4,401,832 | 116,297,000 | 8.00% | ||
| 4 | FMR LLC | 4,224,487 | 111,610,000 | 7.68% | ||
| 5 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,296,618 | 60,676,000 | 4.18% | ||
| 6 | STATE STREET CORP | 2,092,319 | 55,284,000 | 3.80% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,950,085 | 51,521,000 | 3.55% | ||
| 8 | Invesco Ltd. | 1,656,674 | 43,770,000 | 3.01% | ||
| 9 | AMERIPRISE FINANCIAL INC | 1,632,367 | 43,125,000 | 2.97% | ||
| 10 | JENNISON ASSOCIATES LLC | 1,412,410 | 37,316,000 | 2.57% | ||
| 11 | DIMENSIONAL FUND ADVISORS LP | 1,381,862 | 36,507,000 | 2.51% | ||
| 12 | RS INVESTMENT MANAGEMENT CO LLC | 1,328,437 | 35,097,000 | 2.42% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 1,184,725 | 31,300,000 | 2.15% | ||
| 14 | NORTHERN TRUST CORP | 1,089,043 | 28,772,000 | 1.98% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 1,046,000 | 27,635,000 | 1.90% | ||
| 16 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 750,121 | 19,819,000 | 1.36% | ||
| 17 | Bank of New York Mellon Corp | 737,884 | 19,494,000 | 1.34% | ||
| 18 | NORGES BANK | 706,805 | 18,674,000 | 1.28% | ||
| 19 | D. E. Shaw & Co., Inc. | 670,202 | 17,707,000 | 1.22% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 662,063 | 17,492,000 | 1.20% | ||
| 21 | Broadfin Capital, LLC | 633,929 | 16,748,000 | 1.15% | ||
| 22 | Penn Capital Management Company, LLC | 559,245 | 14,775,000 | 1.02% | ||
| 23 | PUTNAM INVESTMENTS LLC | 487,495 | 12,879,000 | 0.89% | ||
| 24 | TURNER INVESTMENTS LLC | 422,220 | 11,155,000 | 0.77% | ||
| 25 | PRINCIPAL FINANCIAL GROUP INC | 411,267 | 10,866,000 | 0.75% | ||
| 26 | FRANKLIN RESOURCES INC | 406,898 | 10,750,000 | 0.74% | ||
| 27 | EAGLE ASSET MANAGEMENT INC | 406,362 | 10,736,000 | 0.74% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 384,498 | 10,158,000 | 0.70% | ||
| 29 | TEACHERS ADVISORS, LLC | 383,757 | 10,139,000 | 0.70% | ||
| 30 | CS MCKEE LP | 365,360 | 9,653,000 | 0.66% | ||
| 31 | PointState Capital LP | 350,000 | 9,247,000 | 0.64% | ||
| 32 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 345,380 | 9,124,940 | 0.63% | ||
| 33 | Tekla Capital Management LLC | 344,683 | 9,107,000 | 0.63% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 318,957 | 8,427,000 | 0.58% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 309,051 | 8,165,000 | 0.56% | ||
| 36 | TWO SIGMA INVESTMENTS, LP | 294,421 | 7,779,000 | 0.54% | ||
| 37 | TWO SIGMA ADVISERS, LP | 274,349 | 7,248,000 | 0.50% | ||
| 38 | BlackRock Investment Management, LLC | 269,191 | 7,112,000 | 0.49% | ||
| 39 | Tradewinds Global Investors, LLC | 262,841 | 6,944,000 | 0.48% | ||
| 40 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 251,700 | 6,650,000 | 0.46% | ||
| 41 | WELLINGTON MANAGEMENT GROUP LLP | 247,779 | 6,546,000 | 0.45% | ||
| 42 | JPMORGAN CHASE & CO | 230,131 | 6,081,000 | 0.42% | ||
| 43 | FEDERATED HERMES, INC. | 221,862 | 5,862,000 | 0.40% | ||
| 44 | HUSSMAN STRATEGIC ADVISORS, INC. | 220,000 | 5,812,000 | 0.40% | ||
| 45 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 202,570 | 5,352,000 | 0.37% | ||
| 46 | DEUTSCHE BANK AG\ | 202,169 | 5,339,000 | 0.37% | ||
| 47 | GOLDMAN SACHS GROUP INC | 200,648 | 5,302,000 | 0.36% | ||
| 48 | PICTET ASSET MANAGEMENT LTD | 165,900 | 4,383,000 | 0.30% | ||
| 49 | PANAGORA ASSET MANAGEMENT INC | 165,509 | 4,373,000 | 0.30% | ||
| 50 | PRUDENTIAL FINANCIAL INC | 156,181 | 4,126,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
