| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 6,739,200 | 309,464,000 | 9.75% | ||
| 2 | Hound Partners, LLC | 5,612,348 | 257,719,000 | 8.12% | ||
| 3 | BlackRock Fund Advisors | 5,380,576 | 247,076,000 | 7.79% | ||
| 4 | VANGUARD GROUP INC | 4,923,816 | 226,101,000 | 7.13% | ||
| 5 | FRANKLIN RESOURCES INC | 3,341,232 | 153,430,000 | 4.84% | ||
| 6 | Pennant Capital Management, LLC | 3,204,096 | 147,132,000 | 4.64% | ||
| 7 | Invesco Ltd. | 3,067,923 | 140,879,000 | 4.44% | ||
| 8 | ARAVT GLOBAL LLC | 3,000,000 | 137,760,000 | 4.34% | ||
| 9 | STATE STREET CORP | 2,151,068 | 98,774,000 | 3.11% | ||
| 10 | Slate Path Capital LP | 1,835,000 | 84,263,000 | 2.66% | ||
| 11 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,762,461 | 80,932,000 | 2.55% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,681,443 | 77,212,000 | 2.43% | ||
| 13 | DIMENSIONAL FUND ADVISORS LP | 1,586,394 | 72,848,000 | 2.30% | ||
| 14 | Southpoint Capital Advisors LP | 1,000,000 | 45,920,000 | 1.45% | ||
| 15 | AMERIPRISE FINANCIAL INC | 886,591 | 40,712,000 | 1.28% | ||
| 16 | NORTHERN TRUST CORP | 883,553 | 40,573,000 | 1.28% | ||
| 17 | KORNITZER CAPITAL MANAGEMENT INC /KS | 831,740 | 38,194,000 | 1.20% | ||
| 18 | MORGAN STANLEY | 768,270 | 35,279,000 | 1.11% | ||
| 19 | NWQ INVESTMENT MANAGEMENT COMPANY, LLC | 710,302 | 32,318,000 | 1.02% | ||
| 20 | Bank of New York Mellon Corp | 677,549 | 31,113,000 | 0.98% | ||
| 21 | NORGES BANK | 574,998 | 26,404,000 | 0.83% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 561,783 | 25,797,000 | 0.81% | ||
| 23 | HealthCor Management, L.P. | 550,000 | 25,256,000 | 0.80% | ||
| 24 | Penn Capital Management Company, LLC | 548,711 | 25,197,000 | 0.79% | ||
| 25 | EverPoint Asset Management, LLC | 510,000 | 23,419,000 | 0.74% | ||
| 26 | VICTORY CAPITAL MANAGEMENT INC | 496,609 | 22,805,000 | 0.72% | ||
| 27 | LOOMIS SAYLES & CO L P | 486,059 | 22,320,000 | 0.70% | ||
| 28 | BANBURY PARTNERS LLC | 477,620 | 21,932,000 | 0.69% | ||
| 29 | Krensavage Asset Management, LLC | 455,475 | 20,915,000 | 0.66% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 450,671 | 20,694,000 | 0.65% | ||
| 31 | TIGER GLOBAL MANAGEMENT LLC | 430,000 | 19,746,000 | 0.62% | ||
| 32 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 428,083 | 19,657,571 | 0.62% | ||
| 33 | PRINCIPAL FINANCIAL GROUP INC | 418,565 | 19,221,000 | 0.61% | ||
| 34 | VOYA INVESTMENT MANAGEMENT LLC | 356,766 | 16,383,000 | 0.52% | ||
| 35 | Tekla Capital Management LLC | 344,683 | 15,828,000 | 0.50% | ||
| 36 | BLUE JAY CAPITAL MANAGEMENT, LLC | 325,000 | 14,924,000 | 0.47% | ||
| 37 | FMR LLC | 309,480 | 14,211,000 | 0.45% | ||
| 38 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 292,600 | 13,436,000 | 0.42% | ||
| 39 | TEACHERS ADVISORS, LLC | 287,683 | 13,210,000 | 0.42% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 287,225 | 13,190,000 | 0.42% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 273,693 | 12,568,000 | 0.40% | ||
| 42 | BlackRock Investment Management, LLC | 273,155 | 12,543,000 | 0.40% | ||
| 43 | PUTNAM INVESTMENTS LLC | 268,003 | 12,307,000 | 0.39% | ||
| 44 | CITADEL ADVISORS LLC | 264,738 | 12,157,000 | 0.38% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 259,671 | 11,924,000 | 0.38% | ||
| 46 | TWO SIGMA INVESTMENTS, LP | 243,410 | 11,177,000 | 0.35% | ||
| 47 | DEUTSCHE BANK AG\ | 242,770 | 11,147,000 | 0.35% | ||
| 48 | GOLDMAN SACHS GROUP INC | 220,738 | 10,136,000 | 0.32% | ||
| 49 | Blackstone Inc. | 220,600 | 10,130,000 | 0.32% | ||
| 50 | FRED ALGER MANAGEMENT, LLC | 208,332 | 9,567,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
