| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 6,678,000 | 211,559,000 | 10.22% | ||
| 2 | BlackRock Fund Advisors | 5,017,796 | 158,964,000 | 7.68% | ||
| 3 | VANGUARD GROUP INC | 4,586,280 | 145,293,000 | 7.02% | ||
| 4 | Invesco Ltd. | 3,305,949 | 104,731,000 | 5.06% | ||
| 5 | FMR LLC | 3,019,383 | 95,654,000 | 4.62% | ||
| 6 | FRANKLIN RESOURCES INC | 2,513,082 | 79,615,000 | 3.85% | ||
| 7 | STATE STREET CORP | 2,449,967 | 77,612,000 | 3.75% | ||
| 8 | Slate Path Capital LP | 2,330,000 | 73,814,000 | 3.57% | ||
| 9 | ARAVT GLOBAL LLC | 2,300,000 | 72,864,000 | 3.52% | ||
| 10 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,102,479 | 66,607,000 | 3.22% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,805,324 | 57,193,000 | 2.76% | ||
| 12 | AMERIPRISE FINANCIAL INC | 1,596,636 | 50,581,000 | 2.44% | ||
| 13 | DIMENSIONAL FUND ADVISORS LP | 1,491,963 | 47,267,000 | 2.28% | ||
| 14 | HIGHFIELDS CAPITAL MANAGEMENT LP | 1,400,000 | 44,352,000 | 2.14% | ||
| 15 | JENNISON ASSOCIATES LLC | 1,328,930 | 42,101,000 | 2.03% | ||
| 16 | NORTHERN TRUST CORP | 967,463 | 30,649,000 | 1.48% | ||
| 17 | NWQ INVESTMENT MANAGEMENT COMPANY, LLC | 906,043 | 28,703,000 | 1.39% | ||
| 18 | MORGAN STANLEY | 849,706 | 26,919,000 | 1.30% | ||
| 19 | KORNITZER CAPITAL MANAGEMENT INC /KS | 775,700 | 24,574,000 | 1.19% | ||
| 20 | ROYAL LONDON ASSET MANAGEMENT LTD | 74,700 | 23,915,000 | 1.16% | ||
| 21 | NORGES BANK | 731,551 | 23,176,000 | 1.12% | ||
| 22 | Penn Capital Management Company, LLC | 709,045 | 22,463,000 | 1.09% | ||
| 23 | Bank of New York Mellon Corp | 680,111 | 21,547,000 | 1.04% | ||
| 24 | PUTNAM INVESTMENTS LLC | 617,285 | 19,555,000 | 0.95% | ||
| 25 | VICTORY CAPITAL MANAGEMENT INC | 580,635 | 18,394,000 | 0.89% | ||
| 26 | VOYA INVESTMENT MANAGEMENT LLC | 561,687 | 17,795,000 | 0.86% | ||
| 27 | Pennant Capital Management, LLC | 533,100 | 16,889,000 | 0.82% | ||
| 28 | TEACHERS ADVISORS, LLC | 516,396 | 16,359,000 | 0.79% | ||
| 29 | LOOMIS SAYLES & CO L P | 512,195 | 16,226,000 | 0.78% | ||
| 30 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 509,707 | 16,147,518 | 0.78% | ||
| 31 | PRUDENTIAL FINANCIAL INC | 500,981 | 15,871,000 | 0.77% | ||
| 32 | Krensavage Asset Management, LLC | 423,161 | 13,406,000 | 0.65% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 417,807 | 13,236,000 | 0.64% | ||
| 34 | PRINCIPAL FINANCIAL GROUP INC | 414,243 | 13,123,000 | 0.63% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 404,596 | 12,818,000 | 0.62% | ||
| 36 | Tradewinds Global Investors, LLC | 372,696 | 11,807,000 | 0.57% | ||
| 37 | FEDERATED HERMES, INC. | 350,301 | 11,098,000 | 0.54% | ||
| 38 | Tekla Capital Management LLC | 344,683 | 10,920,000 | 0.53% | ||
| 39 | JPMORGAN CHASE & CO | 329,026 | 10,423,000 | 0.50% | ||
| 40 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 320,900 | 10,166,000 | 0.49% | ||
| 41 | EAGLE ASSET MANAGEMENT INC | 309,862 | 9,816,000 | 0.47% | ||
| 42 | PointState Capital LP | 300,000 | 9,504,000 | 0.46% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 285,246 | 9,037,000 | 0.44% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 283,478 | 8,981,000 | 0.43% | ||
| 45 | NEW AMSTERDAM PARTNERS LLC/NY | 276,169 | 8,749,000 | 0.42% | ||
| 46 | HUSSMAN STRATEGIC ADVISORS, INC. | 250,000 | 7,920,000 | 0.38% | ||
| 47 | BlackRock Investment Management, LLC | 249,485 | 7,904,000 | 0.38% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 199,742 | 7,770,000 | 0.38% | ||
| 49 | DEUTSCHE BANK AG\ | 242,682 | 7,687,000 | 0.37% | ||
| 50 | ArrowMark Colorado Holdings LLC | 232,500 | 7,366,000 | 0.36% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
