| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 6,405,200 | 151,867,000 | 10.56% | ||
| 2 | BlackRock Fund Advisors | 4,698,460 | 111,400,000 | 7.75% | ||
| 3 | VANGUARD GROUP INC | 4,486,056 | 106,365,000 | 7.40% | ||
| 4 | Invesco Ltd. | 3,575,594 | 84,777,000 | 5.90% | ||
| 5 | STATE STREET CORP | 2,722,222 | 64,536,000 | 4.49% | ||
| 6 | Slate Path Capital LP | 2,330,000 | 55,244,000 | 3.84% | ||
| 7 | FMR LLC | 2,297,183 | 54,467,000 | 3.79% | ||
| 8 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,232,414 | 52,931,000 | 3.68% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,836,462 | 43,543,000 | 3.03% | ||
| 10 | AMERIPRISE FINANCIAL INC | 1,544,771 | 36,627,000 | 2.55% | ||
| 11 | DIMENSIONAL FUND ADVISORS LP | 1,425,704 | 33,805,000 | 2.35% | ||
| 12 | HIGHFIELDS CAPITAL MANAGEMENT LP | 1,400,000 | 33,194,000 | 2.31% | ||
| 13 | JENNISON ASSOCIATES LLC | 1,321,280 | 31,328,000 | 2.18% | ||
| 14 | NWQ INVESTMENT MANAGEMENT COMPANY, LLC | 1,298,995 | 30,651,000 | 2.13% | ||
| 15 | NORTHERN TRUST CORP | 991,472 | 23,508,000 | 1.64% | ||
| 16 | Tekla Capital Management LLC | 990,283 | 23,480,000 | 1.63% | ||
| 17 | Tradewinds Global Investors, LLC | 918,733 | 21,783,000 | 1.52% | ||
| 18 | Penn Capital Management Company, LLC | 908,595 | 21,543,000 | 1.50% | ||
| 19 | PUTNAM INVESTMENTS LLC | 840,440 | 19,926,000 | 1.39% | ||
| 20 | RS INVESTMENT MANAGEMENT CO LLC | 809,959 | 19,204,000 | 1.34% | ||
| 21 | FRANKLIN RESOURCES INC | 802,808 | 19,034,000 | 1.32% | ||
| 22 | NEW AMSTERDAM PARTNERS LLC/NY | 774,092 | 18,354,000 | 1.28% | ||
| 23 | NEW YORK STATE COMMON RETIREMENT FUND | 742,551 | 17,606,000 | 1.22% | ||
| 24 | NORGES BANK | 731,551 | 17,345,000 | 1.21% | ||
| 25 | Bank of New York Mellon Corp | 670,820 | 15,907,000 | 1.11% | ||
| 26 | Broadfin Capital, LLC | 658,929 | 15,623,000 | 1.09% | ||
| 27 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 606,600 | 14,382,000 | 1.00% | ||
| 28 | VOYA INVESTMENT MANAGEMENT LLC | 578,914 | 13,726,000 | 0.95% | ||
| 29 | LOOMIS SAYLES & CO L P | 454,323 | 10,772,000 | 0.75% | ||
| 30 | FEDERATED HERMES, INC. | 445,482 | 10,562,000 | 0.73% | ||
| 31 | JPMORGAN CHASE & CO | 431,603 | 10,233,000 | 0.71% | ||
| 32 | PRINCIPAL FINANCIAL GROUP INC | 412,107 | 9,771,000 | 0.68% | ||
| 33 | TEACHERS ADVISORS, LLC | 391,259 | 9,277,000 | 0.65% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 390,925 | 9,268,000 | 0.64% | ||
| 35 | Tekla Capital Management LLC | 322,600 | 7,649,000 | 0.53% | Call | |
| 36 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 320,900 | 7,609,000 | 0.53% | ||
| 37 | EAGLE ASSET MANAGEMENT INC | 316,904 | 7,513,000 | 0.52% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 306,289 | 7,262,000 | 0.51% | ||
| 39 | D. E. Shaw & Co., Inc. | 279,316 | 6,623,000 | 0.46% | ||
| 40 | PRUDENTIAL FINANCIAL INC | 261,581 | 6,202,000 | 0.43% | ||
| 41 | BlackRock Investment Management, LLC | 251,424 | 5,961,000 | 0.41% | ||
| 42 | HUSSMAN STRATEGIC ADVISORS, INC. | 250,000 | 5,928,000 | 0.41% | ||
| 43 | ORBIMED ADVISORS LLC | 250,000 | 5,928,000 | 0.41% | Call | |
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 247,073 | 5,859,000 | 0.41% | ||
| 45 | RUSSELL FRANK CO/ | 238,394 | 5,652,000 | 0.39% | ||
| 46 | ArrowMark Colorado Holdings LLC | 232,500 | 5,513,000 | 0.38% | ||
| 47 | GOLDMAN SACHS GROUP INC | 231,093 | 5,479,000 | 0.38% | ||
| 48 | GOLDMAN SACHS GROUP INC | 230,300 | 5,460,000 | 0.38% | Call | |
| 49 | THRIVENT FINANCIAL FOR LUTHERANS | 228,599 | 5,420,000 | 0.38% | ||
| 50 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 219,630 | 5,208,000 | 0.36% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
