| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 5,415,600 | 162,414,000 | 8.83% | ||
| 2 | BlackRock Fund Advisors | 4,682,088 | 140,416,000 | 7.64% | ||
| 3 | VANGUARD GROUP INC | 4,402,564 | 132,033,000 | 7.18% | ||
| 4 | FMR LLC | 3,776,532 | 113,258,000 | 6.16% | ||
| 5 | Invesco Ltd. | 3,193,231 | 95,765,000 | 5.21% | ||
| 6 | STATE STREET CORP | 2,348,197 | 70,422,000 | 3.83% | ||
| 7 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,192,509 | 65,753,000 | 3.58% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,892,266 | 56,749,000 | 3.09% | ||
| 9 | JENNISON ASSOCIATES LLC | 1,721,415 | 51,625,000 | 2.81% | ||
| 10 | AMERIPRISE FINANCIAL INC | 1,574,550 | 47,221,000 | 2.57% | ||
| 11 | DIMENSIONAL FUND ADVISORS LP | 1,430,292 | 42,895,000 | 2.33% | ||
| 12 | HIGHFIELDS CAPITAL MANAGEMENT LP | 1,400,000 | 41,986,000 | 2.28% | ||
| 13 | LORD, ABBETT & CO. LLC | 1,273,131 | 38,181,000 | 2.08% | ||
| 14 | NWQ INVESTMENT MANAGEMENT COMPANY, LLC | 984,841 | 29,535,000 | 1.61% | ||
| 15 | NORTHERN TRUST CORP | 966,018 | 28,970,000 | 1.58% | ||
| 16 | RS INVESTMENT MANAGEMENT CO LLC | 940,950 | 28,219,000 | 1.53% | ||
| 17 | Penn Capital Management Company, LLC | 794,641 | 23,831,000 | 1.30% | ||
| 18 | Bank of New York Mellon Corp | 759,681 | 22,783,000 | 1.24% | ||
| 19 | FRANKLIN RESOURCES INC | 756,406 | 22,685,000 | 1.23% | ||
| 20 | NEW YORK STATE COMMON RETIREMENT FUND | 715,551 | 21,459,000 | 1.17% | ||
| 21 | GUGGENHEIM CAPITAL LLC | 701,300 | 21,032,000 | 1.14% | ||
| 22 | NEW AMSTERDAM PARTNERS LLC/NY | 695,100 | 20,846,000 | 1.13% | ||
| 23 | NORGES BANK | 664,390 | 19,925,000 | 1.08% | ||
| 24 | LOOMIS SAYLES & CO L P | 633,102 | 18,986,000 | 1.03% | ||
| 25 | Broadfin Capital, LLC | 608,929 | 18,262,000 | 0.99% | ||
| 26 | VOYA INVESTMENT MANAGEMENT LLC | 589,143 | 17,668,000 | 0.96% | ||
| 27 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 561,363 | 16,835,000 | 0.92% | ||
| 28 | PFM Health Sciences, LP | 534,228 | 16,021,000 | 0.87% | ||
| 29 | JPMORGAN CHASE & CO | 517,301 | 15,513,000 | 0.84% | ||
| 30 | PointState Capital LP | 500,000 | 14,995,000 | 0.82% | ||
| 31 | PUTNAM INVESTMENTS LLC | 480,488 | 14,410,000 | 0.78% | ||
| 32 | THOMPSON SIEGEL & WALMSLEY LLC | 421,581 | 12,643,000 | 0.69% | ||
| 33 | PRINCIPAL FINANCIAL GROUP INC | 413,157 | 12,390,000 | 0.67% | ||
| 34 | TEACHERS ADVISORS, LLC | 393,049 | 11,788,000 | 0.64% | ||
| 35 | ACADIAN ASSET MANAGEMENT LLC | 391,907 | 11,751,000 | 0.64% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 389,480 | 11,680,000 | 0.64% | ||
| 37 | EAGLE ASSET MANAGEMENT INC | 349,940 | 10,494,000 | 0.57% | ||
| 38 | Tekla Capital Management LLC | 344,683 | 10,337,000 | 0.56% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 337,890 | 10,133,000 | 0.55% | ||
| 40 | HUSSMAN STRATEGIC ADVISORS, INC. | 310,000 | 9,297,000 | 0.51% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 309,913 | 9,294,000 | 0.51% | ||
| 42 | CS MCKEE LP | 309,480 | 9,211,000 | 0.50% | ||
| 43 | WELLINGTON MANAGEMENT GROUP LLP | 295,398 | 8,859,000 | 0.48% | ||
| 44 | TURNER INVESTMENTS LLC | 285,970 | 8,577,000 | 0.47% | ||
| 45 | THRIVENT FINANCIAL FOR LUTHERANS | 284,549 | 8,534,000 | 0.46% | ||
| 46 | GOLDMAN SACHS GROUP INC | 277,986 | 8,337,000 | 0.45% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 259,532 | 7,784,000 | 0.42% | ||
| 48 | PANAGORA ASSET MANAGEMENT INC | 256,238 | 7,685,000 | 0.42% | ||
| 49 | ArrowMark Colorado Holdings LLC | 253,977 | 7,617,000 | 0.41% | ||
| 50 | Independence Capital Asset Partners, LLC | 253,089 | 7,590,000 | 0.41% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
