| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 6,171,440 | 78,069,000 | 30.80% | ||
| 2 | BlackRock Finance, Inc. | 2,649,669 | 33,519,000 | 13.22% | ||
| 3 | VANGUARD GROUP INC | 2,333,254 | 29,516,000 | 11.64% | ||
| 4 | NORGES BANK | 985,712 | 12,469,000 | 4.92% | ||
| 5 | FOLGER HILL ASSET MANAGEMENT LP | 780,283 | 9,871,000 | 3.89% | ||
| 6 | Mirae Asset Global Investments Co., Ltd. | 634,001 | 8,020,000 | 3.16% | ||
| 7 | DIMENSIONAL FUND ADVISORS LP | 570,469 | 7,217,000 | 2.85% | ||
| 8 | STATE STREET CORP | 471,514 | 5,966,000 | 2.35% | ||
| 9 | Invesco Ltd. | 438,964 | 5,553,000 | 2.19% | ||
| 10 | NORTHERN TRUST CORP | 314,825 | 3,983,000 | 1.57% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 305,500 | 3,865,000 | 1.52% | Put | |
| 12 | FMR LLC | 254,588 | 3,221,000 | 1.27% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 252,198 | 3,190,000 | 1.26% | ||
| 14 | CREDIT AGRICOLE S A | 182,400 | 2,307,000 | 0.91% | ||
| 15 | Regal Investment Advisors LLC | 181,603 | 2,297,000 | 0.91% | ||
| 16 | QS Investors, LLC | 180,309 | 2,281,000 | 0.90% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 175,800 | 2,224,000 | 0.88% | Call | |
| 18 | STRS OHIO | 175,000 | 2,213,000 | 0.87% | ||
| 19 | Bank of New York Mellon Corp | 156,471 | 1,980,000 | 0.78% | ||
| 20 | ALLIANCEBERNSTEIN L.P. | 140,840 | 1,782,000 | 0.70% | ||
| 21 | GOLDMAN SACHS GROUP INC | 137,453 | 1,738,000 | 0.69% | ||
| 22 | MORGAN STANLEY | 136,792 | 1,730,000 | 0.68% | ||
| 23 | D. E. Shaw & Co., Inc. | 130,525 | 1,651,000 | 0.65% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 128,633 | 1,627,000 | 0.64% | ||
| 25 | DEUTSCHE BANK AG\ | 90,522 | 1,144,000 | 0.45% | ||
| 26 | SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | 87,500 | 1,107,000 | 0.44% | ||
| 27 | GAM Holding AG | 83,940 | 1,062,000 | 0.42% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 79,943 | 1,012,000 | 0.40% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 75,500 | 955,000 | 0.38% | ||
| 30 | CITADEL ADVISORS LLC | 71,408 | 903,000 | 0.36% | ||
| 31 | BANK OF MONTREAL /CAN/ | 71,304 | 902,000 | 0.36% | ||
| 32 | Gotham Asset Management, LLC | 70,484 | 892,000 | 0.35% | ||
| 33 | Quantitative Investment Management, LLC | 69,500 | 879,000 | 0.35% | ||
| 34 | Freedom Investment Management, Inc. | 66,121 | 836,000 | 0.33% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 64,048 | 810,000 | 0.32% | ||
| 36 | BANK OF MONTREAL /CAN/ | 56,000 | 708,000 | 0.28% | Put | |
| 37 | JPMORGAN CHASE & CO | 53,323 | 674,000 | 0.27% | ||
| 38 | CITADEL ADVISORS LLC | 53,100 | 672,000 | 0.27% | Put | |
| 39 | GSA CAPITAL PARTNERS LLP | 48,600 | 615,000 | 0.24% | ||
| 40 | MARSHALL WACE NORTH AMERICA, L.P. | 47,096 | 612,000 | 0.24% | ||
| 41 | TEACHERS ADVISORS, LLC | 45,016 | 569,000 | 0.22% | ||
| 42 | Weiss Multi-Strategy Advisers LLC | 44,500 | 563,000 | 0.22% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,544 | 538,000 | 0.21% | ||
| 44 | ProShare Advisors LLC | 39,145 | 495,000 | 0.20% | ||
| 45 | DekaBank Deutsche Girozentrale | 37,700 | 487,000 | 0.19% | ||
| 46 | Cambridge Investment Research Advisors, Inc. | 37,885 | 479,000 | 0.19% | ||
| 47 | DUPONT CAPITAL MANAGEMENT CORP | 36,606 | 463,000 | 0.18% | ||
| 48 | Swiss National Bank | 35,900 | 454,000 | 0.18% | ||
| 49 | Horizon Kinetics LLC | 35,236 | 446,000 | 0.18% | ||
| 50 | RENAISSANCE TECHNOLOGIES LLC | 35,000 | 443,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
