| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,760,581 | 46,212,000 | 25.67% | ||
| 2 | C Partners Holding GmbH | 1,312,128 | 21,965,000 | 12.20% | ||
| 3 | GREAT POINT PARTNERS LLC | 1,110,000 | 18,581,000 | 10.32% | ||
| 4 | ONTARIO TEACHERS PENSION PLAN BOARD | 547,683 | 9,168,000 | 5.09% | ||
| 5 | EMERALD MUTUAL FUND ADVISERS TRUST | 362,312 | 6,065,000 | 3.37% | ||
| 6 | EMERALD ADVISERS, LLC | 351,521 | 5,884,000 | 3.27% | ||
| 7 | RENAISSANCE TECHNOLOGIES LLC | 311,000 | 5,206,000 | 2.89% | ||
| 8 | ALPS ADVISORS INC | 27,896 | 4,670,000 | 2.59% | ||
| 9 | BlackRock Fund Advisors | 258,561 | 4,328,000 | 2.40% | ||
| 10 | WALL STREET ASSOCIATES | 225,000 | 3,766,000 | 2.09% | ||
| 11 | VANGUARD GROUP INC | 212,543 | 3,558,000 | 1.98% | ||
| 12 | Opaleye Management Inc. | 165,700 | 2,774,000 | 1.54% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 163,999 | 2,745,000 | 1.52% | ||
| 14 | TFS CAPITAL LLC | 159,291 | 2,667,000 | 1.48% | ||
| 15 | BOW STREET LLC | 151,870 | 2,542,000 | 1.41% | ||
| 16 | FIL Ltd | 150,959 | 2,527,000 | 1.40% | ||
| 17 | STATE STREET CORP | 138,487 | 2,319,000 | 1.29% | ||
| 18 | NORTHERN TRUST CORP | 120,335 | 2,014,000 | 1.12% | ||
| 19 | Invesco Ltd. | 114,131 | 1,911,000 | 1.06% | ||
| 20 | ACADIAN ASSET MANAGEMENT LLC | 105,039 | 1,759,000 | 0.98% | ||
| 21 | Sio Capital Management, LLC | 101,766 | 1,704,000 | 0.95% | ||
| 22 | Alyeska Investment Group, L.P. | 98,380 | 1,647,000 | 0.91% | ||
| 23 | DEUTSCHE BANK AG\ | 97,399 | 1,628,000 | 0.90% | ||
| 24 | State of New Jersey Common Pension Fund D | 93,500 | 1,565,000 | 0.87% | ||
| 25 | SABBY MANAGEMENT, LLC | 76,717 | 1,284,000 | 0.71% | ||
| 26 | MARSHALL WACE, LLP | 68,848 | 1,153,000 | 0.64% | ||
| 27 | SMITH ASSET MANAGEMENT GROUP LP | 65,640 | 1,099,000 | 0.61% | ||
| 28 | JPMORGAN CHASE & CO | 61,728 | 1,033,000 | 0.57% | ||
| 29 | Bank of New York Mellon Corp | 55,951 | 937,000 | 0.52% | ||
| 30 | Spark Investment Management LLC | 55,900 | 935,000 | 0.52% | ||
| 31 | Granite Point Capital Management, L.P. | 55,631 | 931,000 | 0.52% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 53,551 | 896,000 | 0.50% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 51,486 | 861,000 | 0.48% | ||
| 34 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,874 | 834,000 | 0.46% | ||
| 35 | ZACKS INVESTMENT MANAGEMENT | 45,317 | 759,000 | 0.42% | ||
| 36 | BLACKROCK ADVISORS LLC | 44,937 | 752,000 | 0.42% | ||
| 37 | PRIVATE ASSET MANAGEMENT INC | 41,000 | 686,000 | 0.38% | ||
| 38 | BlackRock Investment Management, LLC | 40,504 | 678,000 | 0.38% | ||
| 39 | RUSSELL FRANK CO/ | 38,121 | 638,000 | 0.35% | ||
| 40 | AMERICAN CENTURY COMPANIES INC | 35,449 | 593,000 | 0.33% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 34,699 | 581,000 | 0.32% | ||
| 42 | GSA CAPITAL PARTNERS LLP | 32,403 | 542,000 | 0.30% | ||
| 43 | JW Asset Management, LLC | 30,140 | 505,000 | 0.28% | ||
| 44 | Cheyne Capital Management (UK) LLP | 30,000 | 502,000 | 0.28% | ||
| 45 | BINGHAM OSBORN & SCARBOROUGH LLC | 30,000 | 502,000 | 0.28% | ||
| 46 | STRS OHIO | 27,100 | 453,000 | 0.25% | ||
| 47 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 25,000 | 419,000 | 0.23% | ||
| 48 | Nine Chapters Capital Management LLC | 23,000 | 385,000 | 0.21% | ||
| 49 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 20,840 | 349,000 | 0.19% | ||
| 50 | Asset Management One Co., Ltd. | 19,034 | 319,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
