| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,733,981 | 46,204,000 | 16.93% | ||
| 2 | GREAT POINT PARTNERS LLC | 2,601,351 | 43,963,000 | 16.10% | ||
| 3 | Brenner West Capital Advisors, LP | 1,221,463 | 20,643,000 | 7.56% | ||
| 4 | BlackRock Fund Advisors | 854,745 | 14,445,000 | 5.29% | ||
| 5 | ALLIANCEBERNSTEIN L.P. | 735,394 | 12,428,000 | 4.55% | ||
| 6 | VANGUARD GROUP INC | 649,594 | 10,978,000 | 4.02% | ||
| 7 | EMERALD MUTUAL FUND ADVISERS TRUST | 571,789 | 9,663,000 | 3.54% | ||
| 8 | ONTARIO TEACHERS PENSION PLAN BOARD | 547,683 | 9,256,000 | 3.39% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 539,849 | 9,123,000 | 3.34% | ||
| 10 | ARMISTICE CAPITAL, LLC | 536,000 | 9,058,000 | 3.32% | ||
| 11 | EMERALD ADVISERS, LLC | 518,545 | 8,763,000 | 3.21% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 349,005 | 5,898,000 | 2.16% | ||
| 13 | Opaleye Management Inc. | 285,000 | 4,817,000 | 1.76% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 270,000 | 4,563,000 | 1.67% | ||
| 15 | STATE STREET CORP | 257,685 | 4,356,000 | 1.60% | ||
| 16 | Granite Point Capital Management, L.P. | 256,031 | 4,327,000 | 1.59% | ||
| 17 | NORTHERN TRUST CORP | 199,298 | 3,368,000 | 1.23% | ||
| 18 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 185,234 | 3,130,000 | 1.15% | ||
| 19 | JPMORGAN CHASE & CO | 180,384 | 3,049,000 | 1.12% | ||
| 20 | FIL Ltd | 180,107 | 3,044,000 | 1.12% | ||
| 21 | BAKER BROS. ADVISORS LP | 172,630 | 2,917,000 | 1.07% | ||
| 22 | Point72 Asset Management, L.P. | 164,450 | 2,779,000 | 1.02% | ||
| 23 | NEXTHERA CAPITAL LP | 151,670 | 2,563,000 | 0.94% | ||
| 24 | Cheyne Capital Management (UK) LLP | 144,765 | 2,448,000 | 0.90% | ||
| 25 | Rhenman & Partners Asset Management AB | 130,000 | 2,197,000 | 0.80% | ||
| 26 | DIMENSIONAL FUND ADVISORS LP | 126,494 | 2,138,000 | 0.78% | ||
| 27 | Tekla Capital Management LLC | 125,504 | 2,121,000 | 0.78% | ||
| 28 | MOSAIC FAMILY WEALTH, LLC | 123,314 | 2,084,000 | 0.76% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 119,873 | 2,025,000 | 0.74% | ||
| 30 | BINGHAM OSBORN & SCARBOROUGH LLC | 117,450 | 1,985,000 | 0.73% | ||
| 31 | State of New Jersey Common Pension Fund D | 93,500 | 1,580,000 | 0.58% | ||
| 32 | J. Goldman & Co LP | 71,500 | 1,208,000 | 0.44% | ||
| 33 | Sio Capital Management, LLC | 69,215 | 1,170,000 | 0.43% | ||
| 34 | BlackRock Investment Management, LLC | 68,213 | 1,153,000 | 0.42% | ||
| 35 | Bank of New York Mellon Corp | 64,267 | 1,086,000 | 0.40% | ||
| 36 | Opus Point Partners Management, LLC | 60,000 | 1,014,000 | 0.37% | ||
| 37 | MORGAN STANLEY | 55,928 | 944,000 | 0.35% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 47,866 | 809,000 | 0.30% | ||
| 39 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 44,134 | 746,000 | 0.27% | ||
| 40 | PRIVATE ASSET MANAGEMENT INC | 39,000 | 659,000 | 0.24% | ||
| 41 | BAMCO INC /NY/ | 39,000 | 659,000 | 0.24% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,414 | 582,000 | 0.21% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,028 | 491,000 | 0.18% | ||
| 44 | RUSSELL INVESTMENTS GROUP, LTD. | 26,917 | 469,000 | 0.17% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,472 | 465,000 | 0.17% | ||
| 46 | TEACHERS ADVISORS, LLC | 26,961 | 456,000 | 0.17% | ||
| 47 | Allianz Asset Management GmbH | 24,528 | 415,000 | 0.15% | ||
| 48 | ALPS ADVISORS INC | 21,125 | 357,000 | 0.13% | ||
| 49 | GAM Holding AG | 20,000 | 338,000 | 0.12% | ||
| 50 | GOLDMAN SACHS GROUP INC | 19,461 | 329,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
