| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,733,981 | 44,865,000 | 16.37% | ||
| 2 | GREAT POINT PARTNERS LLC | 2,601,351 | 42,688,000 | 15.58% | ||
| 3 | Brenner West Capital Advisors, LP | 1,169,275 | 19,188,000 | 7.00% | ||
| 4 | BOW STREET LLC | 1,153,022 | 18,921,000 | 6.91% | ||
| 5 | BlackRock Fund Advisors | 757,473 | 12,430,000 | 4.54% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 717,375 | 11,772,000 | 4.30% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 698,508 | 11,463,000 | 4.18% | ||
| 8 | VANGUARD GROUP INC | 623,838 | 10,237,000 | 3.74% | ||
| 9 | EMERALD MUTUAL FUND ADVISERS TRUST | 571,789 | 9,383,000 | 3.42% | ||
| 10 | ONTARIO TEACHERS PENSION PLAN BOARD | 547,683 | 8,987,000 | 3.28% | ||
| 11 | EMERALD ADVISERS, LLC | 504,474 | 8,278,000 | 3.02% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 294,600 | 4,834,000 | 1.76% | ||
| 13 | NEXTHERA CAPITAL LP | 278,740 | 4,574,000 | 1.67% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 270,000 | 4,431,000 | 1.62% | ||
| 15 | Opaleye Management Inc. | 250,000 | 4,103,000 | 1.50% | ||
| 16 | STATE STREET CORP | 242,469 | 3,978,000 | 1.45% | ||
| 17 | BINGHAM OSBORN & SCARBOROUGH LLC | 234,900 | 3,855,000 | 1.41% | ||
| 18 | Granite Point Capital Management, L.P. | 224,331 | 3,681,000 | 1.34% | ||
| 19 | NORTHERN TRUST CORP | 192,353 | 3,157,000 | 1.15% | ||
| 20 | FIL Ltd | 180,107 | 2,956,000 | 1.08% | ||
| 21 | BAKER BROS. ADVISORS LP | 172,630 | 2,833,000 | 1.03% | ||
| 22 | JPMORGAN CHASE & CO | 163,450 | 2,683,000 | 0.98% | ||
| 23 | WALL STREET ASSOCIATES | 144,100 | 2,365,000 | 0.86% | ||
| 24 | Point72 Asset Management, L.P. | 130,500 | 2,142,000 | 0.78% | ||
| 25 | Rhenman & Partners Asset Management AB | 130,000 | 2,133,300 | 0.78% | ||
| 26 | MOSAIC FAMILY WEALTH, LLC | 123,314 | 2,024,000 | 0.74% | ||
| 27 | J. Goldman & Co LP | 119,867 | 1,967,000 | 0.72% | ||
| 28 | Cheyne Capital Management (UK) LLP | 114,765 | 1,883,000 | 0.69% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 114,631 | 1,881,000 | 0.69% | ||
| 30 | DIMENSIONAL FUND ADVISORS LP | 97,500 | 1,600,000 | 0.58% | ||
| 31 | State of New Jersey Common Pension Fund D | 93,500 | 1,534,000 | 0.56% | ||
| 32 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 75,099 | 1,232,000 | 0.45% | ||
| 33 | BlackRock Investment Management, LLC | 68,023 | 1,116,000 | 0.41% | ||
| 34 | Sio Capital Management, LLC | 66,110 | 1,085,000 | 0.40% | ||
| 35 | Opus Point Partners Management, LLC | 60,000 | 985,000 | 0.36% | ||
| 36 | C Partners Holding GmbH | 59,273 | 973,000 | 0.36% | ||
| 37 | Bank of New York Mellon Corp | 56,933 | 935,000 | 0.34% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 54,036 | 887,000 | 0.32% | ||
| 39 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 40,000 | 656,000 | 0.24% | ||
| 40 | PRIVATE ASSET MANAGEMENT INC | 39,000 | 640,000 | 0.23% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,214 | 578,000 | 0.21% | ||
| 42 | Allianz Asset Management GmbH | 30,559 | 501,000 | 0.18% | ||
| 43 | JW Asset Management, LLC | 30,140 | 495,000 | 0.18% | ||
| 44 | SABBY MANAGEMENT, LLC | 28,200 | 463,000 | 0.17% | ||
| 45 | ALPS ADVISORS INC | 27,956 | 459,000 | 0.17% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,472 | 451,000 | 0.16% | ||
| 47 | TEACHERS ADVISORS, LLC | 26,961 | 442,000 | 0.16% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,600 | 338,000 | 0.12% | Put | |
| 49 | GAM Holding AG | 20,000 | 328,000 | 0.12% | ||
| 50 | NEW YORK STATE COMMON RETIREMENT FUND | 18,100 | 297,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
