| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,896,481 | 43,853,000 | 18.56% | ||
| 2 | GREAT POINT PARTNERS LLC | 2,109,099 | 31,932,000 | 13.52% | ||
| 3 | Brenner West Capital Advisors, LP | 1,017,000 | 15,397,000 | 6.52% | ||
| 4 | BlackRock Fund Advisors | 704,737 | 10,670,000 | 4.52% | ||
| 5 | ALLIANCEBERNSTEIN L.P. | 651,667 | 9,866,000 | 4.18% | ||
| 6 | C Partners Holding GmbH | 637,128 | 9,646,000 | 4.08% | ||
| 7 | VANGUARD GROUP INC | 618,782 | 9,369,000 | 3.97% | ||
| 8 | EMERALD MUTUAL FUND ADVISERS TRUST | 559,879 | 8,477,000 | 3.59% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 556,569 | 8,426,000 | 3.57% | ||
| 10 | ONTARIO TEACHERS PENSION PLAN BOARD | 547,683 | 8,292,000 | 3.51% | ||
| 11 | EMERALD ADVISERS, LLC | 510,194 | 7,724,000 | 3.27% | ||
| 12 | Opaleye Management Inc. | 300,000 | 4,542,000 | 1.92% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 270,000 | 4,088,000 | 1.73% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 268,987 | 4,072,000 | 1.72% | ||
| 15 | BINGHAM OSBORN & SCARBOROUGH LLC | 234,900 | 3,556,000 | 1.51% | ||
| 16 | STATE STREET CORP | 224,715 | 3,403,000 | 1.44% | ||
| 17 | Granite Point Capital Management, L.P. | 224,331 | 3,396,000 | 1.44% | ||
| 18 | NORTHERN TRUST CORP | 189,600 | 2,870,000 | 1.21% | ||
| 19 | FIL Ltd | 180,107 | 2,727,000 | 1.15% | ||
| 20 | NEXTHERA CAPITAL LP | 178,240 | 2,699,000 | 1.14% | ||
| 21 | BAKER BROS. ADVISORS LP | 172,630 | 2,614,000 | 1.11% | ||
| 22 | J. Goldman & Co LP | 169,000 | 2,559,000 | 1.08% | ||
| 23 | JPMORGAN CHASE & CO | 155,799 | 2,358,000 | 1.00% | ||
| 24 | Point72 Asset Management, L.P. | 143,700 | 2,176,000 | 0.92% | ||
| 25 | Rhenman & Partners Asset Management AB | 130,000 | 1,968,000 | 0.83% | ||
| 26 | WALL STREET ASSOCIATES | 125,000 | 1,892,000 | 0.80% | ||
| 27 | MOSAIC FAMILY WEALTH, LLC | 123,314 | 1,867,000 | 0.79% | ||
| 28 | Cheyne Capital Management (UK) LLP | 114,765 | 1,737,000 | 0.74% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 112,201 | 1,698,000 | 0.72% | ||
| 30 | Iguana Healthcare Management, LLC | 100,000 | 1,514,000 | 0.64% | ||
| 31 | SABBY MANAGEMENT, LLC | 97,600 | 1,478,000 | 0.63% | ||
| 32 | State of New Jersey Common Pension Fund D | 93,500 | 1,416,000 | 0.60% | ||
| 33 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 72,376 | 1,096,000 | 0.46% | ||
| 34 | BlackRock Investment Management, LLC | 68,141 | 1,032,000 | 0.44% | ||
| 35 | TFS CAPITAL LLC | 62,318 | 943,000 | 0.40% | ||
| 36 | DIMENSIONAL FUND ADVISORS LP | 60,550 | 917,000 | 0.39% | ||
| 37 | Bank of New York Mellon Corp | 60,282 | 912,000 | 0.39% | ||
| 38 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 59,610 | 903,000 | 0.38% | ||
| 39 | Sio Capital Management, LLC | 56,500 | 855,000 | 0.36% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 54,796 | 830,000 | 0.35% | ||
| 41 | ZACKS INVESTMENT MANAGEMENT | 45,273 | 685,000 | 0.29% | ||
| 42 | Opus Point Partners Management, LLC | 45,198 | 684,000 | 0.29% | ||
| 43 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 40,000 | 606,000 | 0.26% | ||
| 44 | PRIVATE ASSET MANAGEMENT INC | 39,000 | 590,000 | 0.25% | ||
| 45 | Trexquant Investment LP | 36,617 | 554,000 | 0.23% | ||
| 46 | Allianz Asset Management GmbH | 36,476 | 552,000 | 0.23% | ||
| 47 | CREDIT SUISSE AG/ | 35,116 | 532,000 | 0.23% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,014 | 530,000 | 0.22% | ||
| 49 | ALPS ADVISORS INC | 30,382 | 460,000 | 0.19% | ||
| 50 | JW Asset Management, LLC | 30,140 | 456,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
