| 1 |
FMR LLC |
2,966,481 |
42,895,000 |
20.56% |
|
|
| 2 |
GREAT POINT PARTNERS LLC |
2,109,099 |
30,498,000 |
14.62% |
|
|
| 3 |
C Partners Holding GmbH |
837,128 |
12,105,000 |
5.80% |
|
|
| 4 |
ALLIANCEBERNSTEIN L.P. |
659,760 |
9,540,000 |
4.57% |
|
|
| 5 |
BlackRock Fund Advisors |
587,187 |
8,491,000 |
4.07% |
|
|
| 6 |
ONTARIO TEACHERS PENSION PLAN BOARD |
547,683 |
7,919,000 |
3.80% |
|
|
| 7 |
Brenner West Capital Advisors, LP |
543,238 |
7,855,000 |
3.77% |
|
|
| 8 |
GILDER GAGNON HOWE & CO LLC |
541,421 |
7,829,000 |
3.75% |
|
|
| 9 |
EMERALD MUTUAL FUND ADVISERS TRUST |
538,578 |
7,788,000 |
3.73% |
|
|
| 10 |
EMERALD ADVISERS, LLC |
510,194 |
7,377,000 |
3.54% |
|
|
| 11 |
VANGUARD GROUP INC |
497,870 |
7,199,000 |
3.45% |
|
|
| 12 |
Opaleye Management Inc. |
320,000 |
6,064,000 |
2.91% |
|
|
| 13 |
SPHERA FUNDS MANAGEMENT LTD. |
270,000 |
3,904,000 |
1.87% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
233,601 |
3,378,000 |
1.62% |
|
|
| 15 |
Iguana Healthcare Management, LLC |
200,000 |
2,892,000 |
1.39% |
|
|
| 16 |
SABBY MANAGEMENT, LLC |
199,890 |
2,890,000 |
1.39% |
|
|
| 17 |
BAKER BROS. ADVISORS LP |
172,630 |
2,496,000 |
1.20% |
|
|
| 18 |
STATE STREET CORP |
170,759 |
2,466,000 |
1.18% |
|
|
| 19 |
FIL Ltd |
150,959 |
2,183,000 |
1.05% |
|
|
| 20 |
NORTHERN TRUST CORP |
139,514 |
2,017,000 |
0.97% |
|
|
| 21 |
WALL STREET ASSOCIATES |
125,000 |
1,807,000 |
0.87% |
|
|
| 22 |
MOSAIC FAMILY WEALTH, LLC |
123,314 |
1,783,000 |
0.85% |
|
|
| 23 |
NEXTHERA CAPITAL LP |
117,000 |
1,692,000 |
0.81% |
|
|
| 24 |
JPMORGAN CHASE & CO |
114,106 |
1,650,000 |
0.79% |
|
|
| 25 |
CITADEL ADVISORS LLC |
108,747 |
1,572,000 |
0.75% |
|
|
| 26 |
State of New Jersey Common Pension Fund D |
93,500 |
1,352,000 |
0.65% |
|
|
| 27 |
GEODE CAPITAL MANAGEMENT, LLC |
89,468 |
1,293,000 |
0.62% |
|
|
| 28 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
72,343 |
1,046,000 |
0.50% |
|
|
| 29 |
Trexquant Investment LP |
68,000 |
983,000 |
0.47% |
|
|
| 30 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
62,610 |
884,000 |
0.42% |
|
|
| 31 |
DEUTSCHE BANK AG\ |
59,765 |
863,000 |
0.41% |
|
|
| 32 |
DIMENSIONAL FUND ADVISORS LP |
59,250 |
857,000 |
0.41% |
|
|
| 33 |
Cheyne Capital Management (UK) LLP |
54,765 |
792,000 |
0.38% |
|
|
| 34 |
Opus Point Partners Management, LLC |
54,000 |
781,000 |
0.37% |
|
|
| 35 |
BlackRock Investment Management, LLC |
49,776 |
720,000 |
0.35% |
|
|
| 36 |
Bank of New York Mellon Corp |
49,480 |
715,000 |
0.34% |
|
|
| 37 |
DAFNA Capital Management LLC |
47,500 |
687,000 |
0.33% |
|
|
| 38 |
ZACKS INVESTMENT MANAGEMENT |
45,633 |
660,000 |
0.32% |
|
|
| 39 |
CREDIT SUISSE AG/ |
43,682 |
632,000 |
0.30% |
|
|
| 40 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
40,000 |
578,000 |
0.28% |
|
|
| 41 |
PRIVATE ASSET MANAGEMENT INC |
39,000 |
564,000 |
0.27% |
|
|
| 42 |
STRS OHIO |
38,800 |
561,000 |
0.27% |
|
|
| 43 |
BLACKROCK ADVISORS LLC |
38,520 |
557,000 |
0.27% |
|
|
| 44 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
36,297 |
525,000 |
0.25% |
|
|
| 45 |
PRUDENTIAL FINANCIAL INC |
33,950 |
491,000 |
0.24% |
|
|
| 46 |
BALYASNY ASSET MANAGEMENT L.P. |
31,120 |
450,000 |
0.22% |
|
|
| 47 |
JW Asset Management, LLC |
30,140 |
436,000 |
0.21% |
|
|
| 48 |
BINGHAM OSBORN & SCARBOROUGH LLC |
30,000 |
434,000 |
0.21% |
|
|
| 49 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
29,281 |
423,000 |
0.20% |
|
|
| 50 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
25,830 |
374,000 |
0.18% |
|
|
