| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,760,581 | 78,180,000 | 24.70% | ||
| 2 | GREAT POINT PARTNERS LLC | 1,437,335 | 40,705,000 | 12.86% | ||
| 3 | C Partners Holding GmbH | 837,128 | 23,707,000 | 7.49% | ||
| 4 | ONTARIO TEACHERS PENSION PLAN BOARD | 547,683 | 15,510,000 | 4.90% | ||
| 5 | BlackRock Fund Advisors | 489,489 | 13,862,000 | 4.38% | ||
| 6 | EMERALD ADVISERS, LLC | 462,051 | 13,085,000 | 4.13% | ||
| 7 | EMERALD MUTUAL FUND ADVISERS TRUST | 451,683 | 12,792,000 | 4.04% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 373,240 | 10,570,000 | 3.34% | ||
| 9 | VANGUARD GROUP INC | 304,694 | 8,628,000 | 2.73% | ||
| 10 | CITADEL ADVISORS LLC | 229,348 | 6,495,000 | 2.05% | ||
| 11 | Opaleye Management Inc. | 190,000 | 5,380,000 | 1.70% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 181,260 | 5,133,000 | 1.62% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 169,900 | 4,812,000 | 1.52% | ||
| 14 | STATE STREET CORP | 159,757 | 4,524,000 | 1.43% | ||
| 15 | FIL Ltd | 150,959 | 4,275,000 | 1.35% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 4,248,000 | 1.34% | ||
| 17 | Informed Momentum Co LLC | 141,448 | 4,006,000 | 1.27% | ||
| 18 | WALL STREET ASSOCIATES | 125,000 | 3,540,000 | 1.12% | ||
| 19 | NORTHERN TRUST CORP | 119,715 | 3,391,000 | 1.07% | ||
| 20 | Sio Capital Management, LLC | 117,257 | 3,321,000 | 1.05% | ||
| 21 | Invesco Ltd. | 115,050 | 3,258,000 | 1.03% | ||
| 22 | Granite Point Capital Management, L.P. | 100,631 | 2,850,000 | 0.90% | ||
| 23 | State of New Jersey Common Pension Fund D | 93,500 | 2,648,000 | 0.84% | ||
| 24 | RUSSELL FRANK CO/ | 83,773 | 2,395,000 | 0.76% | ||
| 25 | Opus Point Partners Management, LLC | 80,000 | 2,266,000 | 0.72% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 74,835 | 2,119,000 | 0.67% | ||
| 27 | DIMENSIONAL FUND ADVISORS LP | 69,411 | 1,966,000 | 0.62% | ||
| 28 | AMERIPRISE FINANCIAL INC | 64,978 | 1,840,000 | 0.58% | ||
| 29 | Bank of New York Mellon Corp | 61,199 | 1,734,000 | 0.55% | ||
| 30 | TFS CAPITAL LLC | 60,709 | 1,719,000 | 0.54% | ||
| 31 | Iguana Healthcare Management, LLC | 60,000 | 1,699,000 | 0.54% | ||
| 32 | JPMORGAN CHASE & CO | 54,981 | 1,557,000 | 0.49% | ||
| 33 | PRIVATE ASSET MANAGEMENT INC | 41,000 | 1,161,000 | 0.37% | ||
| 34 | BlackRock Investment Management, LLC | 40,708 | 1,153,000 | 0.36% | ||
| 35 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 40,000 | 1,133,000 | 0.36% | ||
| 36 | STRS OHIO | 39,800 | 1,127,000 | 0.36% | ||
| 37 | BLACKROCK ADVISORS LLC | 35,789 | 1,014,000 | 0.32% | ||
| 38 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,502 | 1,006,000 | 0.32% | ||
| 39 | ZACKS INVESTMENT MANAGEMENT | 34,836 | 987,000 | 0.31% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 34,699 | 983,000 | 0.31% | ||
| 41 | D. E. Shaw & Co., Inc. | 34,474 | 976,000 | 0.31% | ||
| 42 | JW Asset Management, LLC | 30,140 | 854,000 | 0.27% | ||
| 43 | BINGHAM OSBORN & SCARBOROUGH LLC | 30,000 | 850,000 | 0.27% | ||
| 44 | ACADIAN ASSET MANAGEMENT LLC | 30,034 | 850,000 | 0.27% | ||
| 45 | ALPS ADVISORS INC | 24,268 | 687,000 | 0.22% | ||
| 46 | GLOBEFLEX CAPITAL L P | 21,598 | 612,000 | 0.19% | ||
| 47 | MARSHALL WACE, LLP | 21,348 | 605,000 | 0.19% | ||
| 48 | TWO SIGMA INVESTMENTS, LP | 19,876 | 563,000 | 0.18% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,252 | 545,000 | 0.17% | ||
| 50 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 16,375 | 464,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
