| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 2,601,351 | 45,524,000 | 16.33% | ||
| 2 | FMR LLC | 2,464,181 | 43,123,000 | 15.47% | ||
| 3 | BlackRock Finance, Inc. | 1,300,429 | 22,757,000 | 8.16% | ||
| 4 | Brenner West Capital Advisors, LP | 1,191,282 | 20,847,000 | 7.48% | ||
| 5 | ARMISTICE CAPITAL, LLC | 864,000 | 15,120,000 | 5.42% | ||
| 6 | VANGUARD GROUP INC | 716,419 | 12,537,000 | 4.50% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 699,645 | 12,244,000 | 4.39% | ||
| 8 | EMERALD MUTUAL FUND ADVISERS TRUST | 571,789 | 10,006,000 | 3.59% | ||
| 9 | ONTARIO TEACHERS PENSION PLAN BOARD | 547,683 | 9,584,000 | 3.44% | ||
| 10 | EMERALD ADVISERS, LLC | 518,685 | 9,077,000 | 3.26% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 443,067 | 7,754,000 | 2.78% | ||
| 12 | Opaleye Management Inc. | 290,000 | 5,075,000 | 1.82% | ||
| 13 | STATE STREET CORP | 261,651 | 4,582,000 | 1.64% | ||
| 14 | PURA VIDA INVESTMENTS, LLC | 237,500 | 4,156,000 | 1.49% | ||
| 15 | Granite Point Capital Management, L.P. | 235,515 | 4,122,000 | 1.48% | ||
| 16 | NORTHERN TRUST CORP | 203,819 | 3,567,000 | 1.28% | ||
| 17 | SPHERA FUNDS MANAGEMENT LTD. | 195,500 | 3,421,000 | 1.23% | ||
| 18 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 185,234 | 3,236,000 | 1.16% | ||
| 19 | FIL Ltd | 180,107 | 3,152,000 | 1.13% | ||
| 20 | BAKER BROS. ADVISORS LP | 172,630 | 3,021,000 | 1.08% | ||
| 21 | Rhenman & Partners Asset Management AB | 155,000 | 2,713,000 | 0.97% | ||
| 22 | JPMORGAN CHASE & CO | 153,763 | 2,691,000 | 0.97% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 125,793 | 2,201,000 | 0.79% | ||
| 24 | DIMENSIONAL FUND ADVISORS LP | 125,494 | 2,196,000 | 0.79% | ||
| 25 | MOSAIC FAMILY WEALTH, LLC | 123,314 | 2,158,000 | 0.77% | ||
| 26 | BINGHAM OSBORN & SCARBOROUGH LLC | 121,830 | 2,132,000 | 0.76% | ||
| 27 | Cheyne Capital Management (UK) LLP | 114,765 | 2,006,000 | 0.72% | ||
| 28 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 111,788 | 1,956,000 | 0.70% | ||
| 29 | STATE OF WISCONSIN INVESTMENT BOARD | 100,000 | 1,750,000 | 0.63% | ||
| 30 | State of New Jersey Common Pension Fund D | 93,500 | 1,636,000 | 0.59% | ||
| 31 | BAMCO INC /NY/ | 70,928 | 1,241,000 | 0.45% | ||
| 32 | Bank of New York Mellon Corp | 65,830 | 1,152,000 | 0.41% | ||
| 33 | GOLDMAN SACHS GROUP INC | 60,897 | 1,066,000 | 0.38% | ||
| 34 | Opus Point Partners Management, LLC | 60,000 | 1,050,000 | 0.38% | ||
| 35 | Allianz Asset Management GmbH | 55,480 | 971,000 | 0.35% | ||
| 36 | Point72 Asset Management, L.P. | 52,300 | 915,000 | 0.33% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 45,994 | 805,000 | 0.29% | ||
| 38 | PRIVATE ASSET MANAGEMENT INC | 34,000 | 595,000 | 0.21% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,914 | 576,000 | 0.21% | ||
| 40 | MORGAN STANLEY | 30,348 | 531,000 | 0.19% | ||
| 41 | TEACHERS ADVISORS, LLC | 28,445 | 498,000 | 0.18% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,472 | 481,000 | 0.17% | ||
| 43 | RUSSELL INVESTMENTS GROUP, LTD. | 22,049 | 386,000 | 0.14% | ||
| 44 | GAM Holding AG | 20,000 | 350,000 | 0.13% | ||
| 45 | RHUMBLINE ADVISERS | 19,472 | 341,000 | 0.12% | ||
| 46 | ALPS ADVISORS INC | 18,910 | 331,000 | 0.12% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 18,101 | 317,000 | 0.11% | ||
| 48 | Trexquant Investment LP | 16,372 | 287,000 | 0.10% | ||
| 49 | WELLS FARGO & COMPANY/MN | 15,166 | 266,000 | 0.10% | ||
| 50 | ARDSLEY ADVISORY PARTNERS LP | 15,000 | 263,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
