| 1 |
FMR LLC |
3,930,414 |
14,385,000 |
31.67% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
3,287,529 |
12,032,000 |
26.49% |
|
|
| 3 |
Polaris Venture Management Co IV LLC |
1,437,441 |
5,261,000 |
11.58% |
|
|
| 4 |
Rock Springs Capital Management LP |
625,000 |
2,288,000 |
5.04% |
|
|
| 5 |
Cormorant Asset Management, LP |
551,354 |
2,018,000 |
4.44% |
|
|
| 6 |
WALL STREET ASSOCIATES |
475,000 |
1,738,000 |
3.83% |
|
|
| 7 |
Granahan Investment Management, LLC |
377,277 |
1,381,000 |
3.04% |
|
|
| 8 |
PRINCIPAL FINANCIAL GROUP INC |
365,700 |
1,338,000 |
2.95% |
|
|
| 9 |
Alyeska Investment Group, L.P. |
284,501 |
1,041,000 |
2.29% |
|
|
| 10 |
VANGUARD GROUP INC |
235,004 |
861,000 |
1.90% |
|
|
| 11 |
BLACKROCK ADVISORS LLC |
181,183 |
663,000 |
1.46% |
|
|
| 12 |
Deer VII & Co. Ltd. |
166,675 |
610,000 |
1.34% |
|
|
| 13 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
102,623 |
376,000 |
0.83% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
88,371 |
323,000 |
0.71% |
|
|
| 15 |
BlackRock Fund Advisors |
45,605 |
167,000 |
0.37% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
42,168 |
154,000 |
0.34% |
|
|
| 17 |
Northeast Financial Consultants Inc |
40,000 |
146,000 |
0.32% |
|
|
| 18 |
MILLENNIUM MANAGEMENT LLC |
22,798 |
83,000 |
0.18% |
|
|
| 19 |
Commonwealth Equity Services, Inc |
20,778 |
76,000 |
0.17% |
|
|
| 20 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
17,839 |
65,000 |
0.14% |
|
|
| 21 |
WEDBUSH SECURITIES INC |
16,387 |
60,000 |
0.13% |
|
|
| 22 |
GOLDMAN SACHS GROUP INC |
13,063 |
48,000 |
0.11% |
|
|
| 23 |
EAGLE GLOBAL ADVISORS LLC |
13,095 |
48,000 |
0.11% |
|
|
| 24 |
BALYASNY ASSET MANAGEMENT L.P. |
12,350 |
45,000 |
0.10% |
|
|
| 25 |
Bank of New York Mellon Corp |
11,738 |
43,000 |
0.09% |
|
|
| 26 |
A.R.T. Advisors, LLC |
11,545 |
42,000 |
0.09% |
|
|
| 27 |
Donald L. Hagan, LLC |
10,000 |
37,000 |
0.08% |
|
|
| 28 |
ROYAL BANK OF CANADA |
4,800 |
18,000 |
0.04% |
|
|
| 29 |
UBS Group AG |
3,817 |
14,000 |
0.03% |
|
|
| 30 |
BlackRock Group LTD |
3,856 |
14,000 |
0.03% |
|
|
| 31 |
BlackRock Investment Management, LLC |
3,295 |
12,000 |
0.03% |
|
|
| 32 |
BlackRock Japan Co. Ltd |
2,953 |
11,000 |
0.02% |
|
|
| 33 |
BANK OF AMERICA CORP /DE/ |
2,500 |
9,000 |
0.02% |
|
|
| 34 |
MORGAN STANLEY |
2,078 |
8,000 |
0.02% |
|
|
| 35 |
Walleye Trading LLC |
1,900 |
7,000 |
0.02% |
|
|
| 36 |
DEUTSCHE BANK AG\ |
300 |
1,000 |
0.00% |
|
|
| 37 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
193 |
1,000 |
0.00% |
|
|
| 38 |
REILLY FINANCIAL ADVISORS, LLC |
200 |
1,000 |
0.00% |
|
|
| 39 |
CITIGROUP INC |
34 |
0 |
0.00% |
|
|
