| 1 |
FMR LLC |
3,930,414 |
18,080,000 |
30.87% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
3,287,529 |
15,123,000 |
25.82% |
|
|
| 3 |
Polaris Venture Management Co IV LLC |
1,437,441 |
6,612,000 |
11.29% |
|
|
| 4 |
Rock Springs Capital Management LP |
625,000 |
2,875,000 |
4.91% |
|
|
| 5 |
Cormorant Asset Management, LP |
551,354 |
2,536,000 |
4.33% |
|
|
| 6 |
WALL STREET ASSOCIATES |
475,000 |
2,185,000 |
3.73% |
|
|
| 7 |
PRINCIPAL FINANCIAL GROUP INC |
363,100 |
1,670,000 |
2.85% |
|
|
| 8 |
Granahan Investment Management, LLC |
332,225 |
1,528,000 |
2.61% |
|
|
| 9 |
CLOUGH CAPITAL PARTNERS L P |
276,400 |
1,271,000 |
2.17% |
|
|
| 10 |
Alyeska Investment Group, L.P. |
263,324 |
1,211,000 |
2.07% |
|
|
| 11 |
BLACKROCK ADVISORS LLC |
181,183 |
833,000 |
1.42% |
|
|
| 12 |
Deer VII & Co. Ltd. |
166,675 |
767,000 |
1.31% |
|
|
| 13 |
VANGUARD GROUP INC |
158,567 |
730,000 |
1.25% |
|
|
| 14 |
TFS CAPITAL LLC |
103,648 |
477,000 |
0.81% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
88,189 |
405,000 |
0.69% |
|
|
| 16 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
86,200 |
397,000 |
0.68% |
|
|
| 17 |
Numeric Investors LLC |
85,889 |
395,000 |
0.67% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
60,309 |
277,000 |
0.47% |
|
|
| 19 |
MILLENNIUM MANAGEMENT LLC |
52,865 |
243,000 |
0.41% |
|
|
| 20 |
BlackRock Fund Advisors |
36,642 |
169,000 |
0.29% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
35,992 |
166,000 |
0.28% |
|
|
| 22 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
24,995 |
115,000 |
0.20% |
|
|
| 23 |
EAGLE GLOBAL ADVISORS LLC |
22,170 |
102,000 |
0.17% |
|
|
| 24 |
Northeast Financial Consultants Inc |
20,000 |
92,000 |
0.16% |
|
|
| 25 |
BALYASNY ASSET MANAGEMENT L.P. |
16,865 |
78,000 |
0.13% |
|
|
| 26 |
WEDBUSH SECURITIES INC |
15,950 |
73,000 |
0.12% |
|
|
| 27 |
Creative Planning |
10,300 |
47,000 |
0.08% |
|
|
| 28 |
ROYAL BANK OF CANADA |
4,800 |
22,000 |
0.04% |
|
|
| 29 |
UBS Group AG |
3,817 |
18,000 |
0.03% |
|
|
| 30 |
BlackRock Group LTD |
3,856 |
18,000 |
0.03% |
|
|
| 31 |
BlackRock Investment Management, LLC |
3,295 |
15,000 |
0.03% |
|
|
| 32 |
BlackRock Japan Co. Ltd |
2,953 |
14,000 |
0.02% |
|
|
| 33 |
BANK OF AMERICA CORP /DE/ |
2,500 |
11,000 |
0.02% |
|
|
| 34 |
MORGAN STANLEY |
1,836 |
8,000 |
0.01% |
|
|
| 35 |
GLENMEDE TRUST CO NA |
1,050 |
4,000 |
0.01% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
193 |
1,000 |
0.00% |
|
|
| 37 |
REILLY FINANCIAL ADVISORS, LLC |
200 |
1,000 |
0.00% |
|
|
