| 1 |
FMR LLC |
3,930,414 |
11,005,000 |
32.43% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
3,287,529 |
9,205,000 |
27.12% |
|
|
| 3 |
Polaris Venture Management Co IV LLC |
1,437,441 |
4,025,000 |
11.86% |
|
|
| 4 |
Granahan Investment Management, LLC |
764,375 |
2,140,000 |
6.31% |
|
|
| 5 |
Rock Springs Capital Management LP |
625,000 |
1,750,000 |
5.16% |
|
|
| 6 |
PRINCIPAL FINANCIAL GROUP INC |
365,700 |
1,024,000 |
3.02% |
|
|
| 7 |
Alyeska Investment Group, L.P. |
303,139 |
849,000 |
2.50% |
|
|
| 8 |
VANGUARD GROUP INC |
293,504 |
822,000 |
2.42% |
|
|
| 9 |
WELLS FARGO & COMPANY/MN |
221,698 |
621,000 |
1.83% |
|
|
| 10 |
BLACKROCK ADVISORS LLC |
179,565 |
503,000 |
1.48% |
|
|
| 11 |
Deer VII & Co. Ltd. |
166,675 |
467,000 |
1.38% |
|
|
| 12 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
102,623 |
287,000 |
0.85% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
88,553 |
247,000 |
0.73% |
|
|
| 14 |
NEXTHERA CAPITAL LP |
50,000 |
140,000 |
0.41% |
|
|
| 15 |
BlackRock Fund Advisors |
47,201 |
132,000 |
0.39% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
46,726 |
131,000 |
0.39% |
|
|
| 17 |
Bank of New York Mellon Corp |
31,145 |
87,000 |
0.26% |
|
|
| 18 |
Commonwealth Equity Services, Inc |
20,778 |
58,000 |
0.17% |
|
|
| 19 |
Northeast Financial Consultants Inc |
20,000 |
56,000 |
0.17% |
|
|
| 20 |
A.R.T. Advisors, LLC |
19,545 |
54,000 |
0.16% |
|
|
| 21 |
WEDBUSH SECURITIES INC |
16,000 |
45,000 |
0.13% |
|
|
| 22 |
Donald L. Hagan, LLC |
15,000 |
42,000 |
0.12% |
|
|
| 23 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
13,062 |
37,000 |
0.11% |
|
|
| 24 |
GOLDMAN SACHS GROUP INC |
12,780 |
36,000 |
0.11% |
|
|
| 25 |
MILLENNIUM MANAGEMENT LLC |
12,460 |
35,000 |
0.10% |
|
|
| 26 |
EAGLE GLOBAL ADVISORS LLC |
10,475 |
29,000 |
0.09% |
|
|
| 27 |
BANK OF AMERICA CORP /DE/ |
8,298 |
24,000 |
0.07% |
|
|
| 28 |
Tower Research Capital LLC (TRC) |
6,380 |
18,000 |
0.05% |
|
|
| 29 |
ROYAL BANK OF CANADA |
4,800 |
13,000 |
0.04% |
|
|
| 30 |
UBS Group AG |
3,817 |
11,000 |
0.03% |
|
|
| 31 |
BlackRock Group LTD |
3,856 |
11,000 |
0.03% |
|
|
| 32 |
BlackRock Japan Co. Ltd |
3,466 |
10,000 |
0.03% |
|
|
| 33 |
BlackRock Investment Management, LLC |
3,549 |
10,000 |
0.03% |
|
|
| 34 |
MORGAN STANLEY |
2,478 |
7,000 |
0.02% |
|
|
| 35 |
CITIGROUP INC |
1,700 |
5,000 |
0.01% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
193 |
1,000 |
0.00% |
|
|
| 37 |
REILLY FINANCIAL ADVISORS, LLC |
200 |
1,000 |
0.00% |
|
|
