| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,437,811 | 11,157,000 | 33.96% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 869,800 | 6,749,000 | 20.54% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 690,538 | 5,359,000 | 16.31% | ||
| 4 | SABBY MANAGEMENT, LLC | 266,953 | 2,072,000 | 6.31% | ||
| 5 | SPHERA FUNDS MANAGEMENT LTD. | 265,000 | 2,056,000 | 6.26% | ||
| 6 | BAKER BROS. ADVISORS LP | 142,000 | 1,102,000 | 3.35% | ||
| 7 | Knoll Capital Management, LLC | 135,800 | 1,054,000 | 3.21% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 119,000 | 923,000 | 2.81% | ||
| 9 | VANGUARD GROUP INC | 103,470 | 802,000 | 2.44% | ||
| 10 | PURA VIDA INVESTMENTS, LLC | 57,500 | 511,000 | 1.56% | ||
| 11 | Nicholas Investment Partners, LP | 40,788 | 317,000 | 0.96% | ||
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 22,558 | 175,000 | 0.53% | ||
| 13 | Spark Investment Management LLC | 22,000 | 170,000 | 0.52% | ||
| 14 | Weiss Multi-Strategy Advisers LLC | 17,500 | 136,000 | 0.41% | ||
| 15 | MORGAN STANLEY | 16,504 | 128,000 | 0.39% | ||
| 16 | NORTHERN TRUST CORP | 11,106 | 86,000 | 0.26% | ||
| 17 | Vantage Investment Advisors, LLC | 2,000 | 16,000 | 0.05% | ||
| 18 | UBS Group AG | 1,922 | 15,000 | 0.05% | ||
| 19 | BLACKROCK ADVISORS LLC | 1,184 | 9,000 | 0.03% | ||
| 20 | BlackRock Investment Management, LLC | 958 | 7,000 | 0.02% | ||
| 21 | Ironwood Financial, llc | 500 | 4,000 | 0.01% | ||
| 22 | Walleye Trading LLC | 400 | 3,000 | 0.01% | ||
| 23 | Tower Research Capital LLC (TRC) | 220 | 2,000 | 0.01% | ||
| 24 | DEUTSCHE BANK AG\ | 29 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
