| 1 |
FMR LLC |
1,437,811 |
6,024,000 |
33.01% |
|
|
| 2 |
PERCEPTIVE ADVISORS LLC |
1,240,458 |
5,197,000 |
28.48% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
471,259 |
1,975,000 |
10.82% |
|
|
| 4 |
SPHERA FUNDS MANAGEMENT LTD. |
238,500 |
999,000 |
5.47% |
|
|
| 5 |
DAFNA Capital Management LLC |
176,232 |
738,000 |
4.04% |
|
|
| 6 |
BAKER BROS. ADVISORS LP |
142,000 |
595,000 |
3.26% |
|
|
| 7 |
Knoll Capital Management, LLC |
135,800 |
569,000 |
3.12% |
|
|
| 8 |
VANGUARD GROUP INC |
121,407 |
508,000 |
2.78% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
100,045 |
419,000 |
2.30% |
|
|
| 10 |
Weiss Multi-Strategy Advisers LLC |
71,172 |
298,000 |
1.63% |
|
|
| 11 |
BOXER CAPITAL, LLC |
63,146 |
265,000 |
1.45% |
|
|
| 12 |
PURA VIDA INVESTMENTS, LLC |
57,500 |
241,000 |
1.32% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
41,096 |
172,000 |
0.94% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
23,558 |
98,000 |
0.54% |
|
|
| 15 |
NORTHERN TRUST CORP |
12,286 |
51,000 |
0.28% |
|
|
| 16 |
FNY Managed Accounts LLC |
6,502 |
27,243 |
0.15% |
|
|
| 17 |
MORGAN STANLEY |
3,589 |
15,000 |
0.08% |
|
|
| 18 |
UBS Group AG |
2,784 |
12,000 |
0.07% |
|
|
| 19 |
BLACKROCK ADVISORS LLC |
2,978 |
12,000 |
0.07% |
|
|
| 20 |
BANK OF AMERICA CORP /DE/ |
2,000 |
8,000 |
0.04% |
|
|
| 21 |
Vantage Investment Advisors, LLC |
2,000 |
8,000 |
0.04% |
|
|
| 22 |
BlackRock Fund Advisors |
1,009 |
4,000 |
0.02% |
|
|
| 23 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
941 |
4,000 |
0.02% |
|
|
| 24 |
BlackRock Investment Management, LLC |
958 |
4,000 |
0.02% |
|
|
| 25 |
Tower Research Capital LLC (TRC) |
636 |
3,000 |
0.02% |
|
|
| 26 |
Walleye Trading LLC |
300 |
1,000 |
0.01% |
|
|
| 27 |
CITIGROUP INC |
4 |
0 |
0.00% |
|
|
