| 1 |
Invesco Ltd. |
1,075,611 |
3,270,000 |
11.17% |
|
|
| 2 |
VHCP Management, LLC |
849,921 |
2,584,000 |
8.83% |
|
|
| 3 |
Cormorant Asset Management, LP |
751,296 |
2,284,000 |
7.80% |
|
|
| 4 |
ROYCE & ASSOCIATES LP |
655,667 |
1,993,000 |
6.81% |
|
|
| 5 |
VANGUARD GROUP INC |
536,582 |
1,631,000 |
5.57% |
|
|
| 6 |
Carlson Capital, L.P. |
510,000 |
1,550,000 |
5.29% |
|
|
| 7 |
BlackRock Fund Advisors |
433,171 |
1,317,000 |
4.50% |
|
|
| 8 |
VHCP MANAGEMENT II, LLC |
420,000 |
1,277,000 |
4.36% |
|
|
| 9 |
GILDER GAGNON HOWE & CO LLC |
404,796 |
1,231,000 |
4.20% |
|
|
| 10 |
ARMISTICE CAPITAL, LLC |
400,000 |
1,216,000 |
4.15% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
365,851 |
1,112,000 |
3.80% |
|
|
| 12 |
FORESITE CAPITAL MANAGEMENT III, LLC |
302,640 |
920,000 |
3.14% |
|
|
| 13 |
PERCEPTIVE ADVISORS LLC |
300,000 |
912,000 |
3.12% |
Call |
|
| 14 |
DIMENSIONAL FUND ADVISORS LP |
296,302 |
901,000 |
3.08% |
|
|
| 15 |
PERCEPTIVE ADVISORS LLC |
284,400 |
865,000 |
2.95% |
Put |
|
| 16 |
TANG CAPITAL MANAGEMENT LLC |
260,000 |
790,000 |
2.70% |
|
|
| 17 |
STATE STREET CORP |
200,679 |
609,000 |
2.08% |
|
|
| 18 |
NORTHERN TRUST CORP |
183,695 |
559,000 |
1.91% |
|
|
| 19 |
DRW Securities, LLC |
145,859 |
443,000 |
1.51% |
|
|
| 20 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
144,800 |
440,000 |
1.50% |
Put |
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
109,000 |
331,000 |
1.13% |
Call |
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
105,136 |
319,000 |
1.09% |
|
|
| 23 |
Lombard Odier Asset Management (USA) Corp |
96,300 |
293,000 |
1.00% |
Call |
|
| 24 |
AMERIPRISE FINANCIAL INC |
67,100 |
204,000 |
0.70% |
|
|
| 25 |
SABBY MANAGEMENT, LLC |
63,875 |
194,000 |
0.66% |
|
|
| 26 |
BlackRock Investment Management, LLC |
62,707 |
191,000 |
0.65% |
|
|
| 27 |
Bank of New York Mellon Corp |
60,907 |
185,000 |
0.63% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
54,470 |
166,000 |
0.57% |
|
|
| 29 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
46,000 |
140,000 |
0.48% |
|
|
| 30 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
34,725 |
106,000 |
0.36% |
|
|
| 31 |
MILLENNIUM MANAGEMENT LLC |
35,000 |
106,000 |
0.36% |
Call |
|
| 32 |
Geduld E E |
30,000 |
91,000 |
0.31% |
|
|
| 33 |
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
28,938 |
88,000 |
0.30% |
|
|
| 34 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
26,100 |
80,000 |
0.27% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
26,005 |
79,000 |
0.27% |
|
|
| 36 |
CUTLER GROUP LLC / CA |
9,300 |
76,000 |
0.26% |
Put |
|
| 37 |
DEUTSCHE BANK AG\ |
23,555 |
70,000 |
0.24% |
|
|
| 38 |
CUTLER GROUP LLC / CA |
19,007 |
57,000 |
0.19% |
|
|
| 39 |
MORGAN STANLEY |
18,424 |
56,000 |
0.19% |
|
|
| 40 |
SG Americas Securities, LLC |
18,155 |
55,000 |
0.19% |
|
|
| 41 |
SOCIETE GENERALE |
18,155 |
55,000 |
0.19% |
|
|
| 42 |
RHUMBLINE ADVISERS |
17,457 |
53,000 |
0.18% |
|
|
| 43 |
NEW YORK STATE COMMON RETIREMENT FUND |
17,100 |
52,000 |
0.18% |
|
|
| 44 |
Connor, Clark & Lunn Investment Management Ltd. |
15,800 |
48,000 |
0.16% |
|
|
| 45 |
Virtu KCG Holdings LLC |
14,361 |
44,000 |
0.15% |
|
|
| 46 |
Spot Trading L.L.C |
14,000 |
43,000 |
0.15% |
Put |
|
| 47 |
Nationwide Fund Advisors |
10,531 |
32,000 |
0.11% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
9,533 |
28,980 |
0.10% |
|
|
| 49 |
CITIGROUP INC |
7,669 |
23,000 |
0.08% |
|
|
| 50 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
7,015 |
21,000 |
0.07% |
|
|
