| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VHCP Management, LLC | 1,269,921 | 15,024,000 | 13.91% | ||
| 2 | Invesco Ltd. | 1,075,000 | 12,718,000 | 11.77% | ||
| 3 | ROYCE & ASSOCIATES LP | 1,018,123 | 12,044,000 | 11.15% | ||
| 4 | Visium Asset Management, LP | 977,768 | 11,567,000 | 10.71% | ||
| 5 | Cormorant Asset Management, LP | 666,666 | 7,887,000 | 7.30% | ||
| 6 | GILDER GAGNON HOWE & CO LLC | 522,495 | 6,181,000 | 5.72% | ||
| 7 | VANGUARD GROUP INC | 391,201 | 4,628,000 | 4.28% | ||
| 8 | Informed Momentum Co LLC | 343,630 | 4,065,000 | 3.76% | ||
| 9 | Lombard Odier Asset Management (USA) Corp | 295,842 | 3,500,000 | 3.24% | ||
| 10 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 295,000 | 3,490,000 | 3.23% | ||
| 11 | RENAISSANCE TECHNOLOGIES LLC | 239,700 | 2,836,000 | 2.63% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 235,675 | 2,788,000 | 2.58% | ||
| 13 | RTW INVESTMENTS, LP | 212,497 | 2,514,000 | 2.33% | ||
| 14 | AMERIPRISE FINANCIAL INC | 206,767 | 2,446,000 | 2.26% | ||
| 15 | SABBY MANAGEMENT, LLC | 201,409 | 2,383,000 | 2.21% | ||
| 16 | TFS CAPITAL LLC | 172,518 | 2,041,000 | 1.89% | ||
| 17 | DIMENSIONAL FUND ADVISORS LP | 156,824 | 1,855,000 | 1.72% | ||
| 18 | Rotella Capital Management, Inc. | 103,946 | 1,230,000 | 1.14% | ||
| 19 | RUSSELL FRANK CO/ | 90,476 | 1,071,000 | 0.99% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 88,917 | 1,051,000 | 0.97% | ||
| 21 | A.R.T. Advisors, LLC | 87,629 | 1,036,000 | 0.96% | ||
| 22 | Bank of New York Mellon Corp | 75,950 | 898,000 | 0.83% | ||
| 23 | CITADEL ADVISORS LLC | 69,295 | 820,000 | 0.76% | ||
| 24 | MORGAN STANLEY | 62,665 | 741,000 | 0.69% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 47,699 | 564,000 | 0.52% | ||
| 26 | DAFNA Capital Management LLC | 45,000 | 532,000 | 0.49% | ||
| 27 | BlackRock Fund Advisors | 36,606 | 433,000 | 0.40% | ||
| 28 | NORTHERN TRUST CORP | 31,922 | 377,000 | 0.35% | ||
| 29 | DEUTSCHE BANK AG\ | 23,783 | 280,000 | 0.26% | ||
| 30 | Trexquant Investment LP | 20,300 | 240,000 | 0.22% | ||
| 31 | GOLDMAN SACHS GROUP INC | 19,391 | 229,000 | 0.21% | ||
| 32 | STATE STREET CORP | 13,100 | 156,000 | 0.14% | ||
| 33 | MENTA CAPITAL LLC | 11,106 | 131,000 | 0.12% | ||
| 34 | PRELUDE CAPITAL MANAGEMENT, LLC | 5,600 | 66,000 | 0.06% | ||
| 35 | PANAGORA ASSET MANAGEMENT INC | 5,225 | 62,000 | 0.06% | ||
| 36 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 4,215 | 50,000 | 0.05% | ||
| 37 | BlackRock Investment Management, LLC | 2,636 | 31,000 | 0.03% | ||
| 38 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 1,450 | 17,000 | 0.02% | ||
| 39 | CITIGROUP INC | 1,000 | 12,000 | 0.01% | ||
| 40 | Walleye Trading LLC | 700 | 8,000 | 0.01% | ||
| 41 | Tower Research Capital LLC (TRC) | 500 | 6,000 | 0.01% | ||
| 42 | UBS Group AG | 342 | 4,000 | 0.00% | ||
| 43 | Creative Planning | 200 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
