| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Invesco Ltd. | 1,075,000 | 10,912,000 | 11.41% | ||
| 2 | Visium Asset Management, LP | 904,707 | 9,183,000 | 9.61% | ||
| 3 | VHCP Management, LLC | 849,921 | 8,627,000 | 9.02% | ||
| 4 | ROYCE & ASSOCIATES LP | 839,357 | 8,519,000 | 8.91% | ||
| 5 | Cormorant Asset Management, LP | 666,666 | 6,767,000 | 7.08% | ||
| 6 | GILDER GAGNON HOWE & CO LLC | 654,399 | 6,642,000 | 6.95% | ||
| 7 | VANGUARD GROUP INC | 470,383 | 4,774,000 | 4.99% | ||
| 8 | VHCP MANAGEMENT II, LLC | 420,000 | 4,263,000 | 4.46% | ||
| 9 | FORESITE CAPITAL MANAGEMENT III, LLC | 397,107 | 4,031,000 | 4.22% | ||
| 10 | Informed Momentum Co LLC | 369,314 | 3,749,000 | 3.92% | ||
| 11 | DIMENSIONAL FUND ADVISORS LP | 291,838 | 2,962,000 | 3.10% | ||
| 12 | Carlson Capital, L.P. | 270,830 | 2,749,000 | 2.88% | ||
| 13 | RTW INVESTMENTS, LP | 240,438 | 2,440,000 | 2.55% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 224,170 | 2,275,000 | 2.38% | ||
| 15 | AMERIPRISE FINANCIAL INC | 197,994 | 2,009,000 | 2.10% | ||
| 16 | SABBY MANAGEMENT, LLC | 151,086 | 1,534,000 | 1.60% | ||
| 17 | Lombard Odier Asset Management (USA) Corp | 118,721 | 1,205,000 | 1.26% | ||
| 18 | TANG CAPITAL MANAGEMENT LLC | 100,000 | 1,015,000 | 1.06% | ||
| 19 | DAFNA Capital Management LLC | 95,731 | 972,000 | 1.02% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 88,967 | 903,000 | 0.94% | ||
| 21 | RUSSELL FRANK CO/ | 81,158 | 824,000 | 0.86% | ||
| 22 | Bank of New York Mellon Corp | 79,871 | 811,000 | 0.85% | ||
| 23 | Allianz Asset Management GmbH | 73,045 | 741,000 | 0.78% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,925 | 700,000 | 0.73% | ||
| 25 | BlackRock Group LTD | 62,034 | 630,000 | 0.66% | ||
| 26 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 58,830 | 597,000 | 0.62% | ||
| 27 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 46,000 | 467,000 | 0.49% | ||
| 28 | NORTHERN TRUST CORP | 39,940 | 406,000 | 0.42% | ||
| 29 | OXFORD ASSET MANAGEMENT LLP | 38,187 | 388,000 | 0.41% | ||
| 30 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 37,891 | 385,000 | 0.40% | ||
| 31 | CREDIT SUISSE AG/ | 36,633 | 372,000 | 0.39% | ||
| 32 | BlackRock Fund Advisors | 35,570 | 361,000 | 0.38% | ||
| 33 | UBS Group AG | 33,109 | 336,000 | 0.35% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 32,345 | 328,000 | 0.34% | ||
| 35 | GOLDMAN SACHS GROUP INC | 32,130 | 326,000 | 0.34% | ||
| 36 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 30,309 | 308,000 | 0.32% | ||
| 37 | MORGAN STANLEY | 27,723 | 281,000 | 0.29% | ||
| 38 | JPMORGAN CHASE & CO | 22,240 | 226,000 | 0.24% | ||
| 39 | Segantii Capital Management Ltd | 21,000 | 219,000 | 0.23% | ||
| 40 | RENAISSANCE TECHNOLOGIES LLC | 19,200 | 195,000 | 0.20% | ||
| 41 | CUTLER GROUP LLC / CA | 18,012 | 182,000 | 0.19% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,400 | 156,000 | 0.16% | Call | |
| 43 | NOMURA HOLDINGS INC | 15,283 | 155,000 | 0.16% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,100 | 143,000 | 0.15% | Put | |
| 45 | STATE STREET CORP | 13,300 | 135,000 | 0.14% | ||
| 46 | DEUTSCHE BANK AG\ | 10,353 | 105,000 | 0.11% | ||
| 47 | CUTLER GROUP LLC / CA | 13,900 | 78,000 | 0.08% | Put | |
| 48 | SIMPLEX TRADING, LLC | 5,737 | 58,000 | 0.06% | ||
| 49 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 4,215 | 43,000 | 0.04% | ||
| 50 | BlackRock Investment Management, LLC | 2,538 | 26,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
