| 1 |
NEA Management Company, LLC |
10,294,096 |
177,882,000 |
50.06% |
|
|
| 2 |
FMR LLC |
2,828,921 |
48,884,000 |
13.76% |
|
|
| 3 |
Cormorant Asset Management, LP |
1,481,075 |
25,593,000 |
7.20% |
|
|
| 4 |
RA CAPITAL MANAGEMENT, L.P. |
1,064,013 |
18,386,000 |
5.17% |
|
|
| 5 |
Rock Springs Capital Management LP |
681,500 |
11,776,000 |
3.31% |
|
|
| 6 |
Tekla Capital Management LLC |
640,270 |
11,064,000 |
3.11% |
|
|
| 7 |
Broadfin Capital, LLC |
549,290 |
9,492,000 |
2.67% |
|
|
| 8 |
BlackRock Fund Advisors |
438,899 |
7,584,000 |
2.13% |
|
|
| 9 |
ALPS ADVISORS INC |
40,558 |
7,008,000 |
1.97% |
|
|
| 10 |
VANGUARD GROUP INC |
357,442 |
6,176,000 |
1.74% |
|
|
| 11 |
WALL STREET ASSOCIATES |
215,200 |
3,719,000 |
1.05% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
203,802 |
3,522,000 |
0.99% |
|
|
| 13 |
NORTHERN TRUST CORP |
166,510 |
2,877,000 |
0.81% |
|
|
| 14 |
MORGAN STANLEY |
143,807 |
2,485,000 |
0.70% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
138,697 |
2,396,000 |
0.67% |
|
|
| 16 |
PUTNAM INVESTMENTS LLC |
107,729 |
1,862,000 |
0.52% |
|
|
| 17 |
JPMORGAN CHASE & CO |
99,875 |
1,725,000 |
0.49% |
|
|
| 18 |
BLACKROCK ADVISORS LLC |
76,810 |
1,327,000 |
0.37% |
|
|
| 19 |
PRINCIPAL FINANCIAL GROUP INC |
69,622 |
1,203,000 |
0.34% |
|
|
| 20 |
BlackRock Investment Management, LLC |
57,345 |
991,000 |
0.28% |
|
|
| 21 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
53,540 |
925,000 |
0.26% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
49,845 |
861,000 |
0.24% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
45,987 |
794,000 |
0.22% |
|
|
| 24 |
GSA CAPITAL PARTNERS LLP |
43,271 |
748,000 |
0.21% |
|
|
| 25 |
Bank of New York Mellon Corp |
39,511 |
682,000 |
0.19% |
|
|
| 26 |
MILLENNIUM MANAGEMENT LLC |
35,894 |
620,000 |
0.17% |
|
|
| 27 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
30,254 |
523,000 |
0.15% |
|
|
| 28 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
30,000 |
518,000 |
0.15% |
|
|
| 29 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
23,940 |
414,000 |
0.12% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
19,595 |
339,000 |
0.10% |
|
|
| 31 |
CITIGROUP INC |
15,829 |
273,000 |
0.08% |
|
|
| 32 |
ClariVest Asset Management LLC |
15,200 |
263,000 |
0.07% |
|
|
| 33 |
J.P. Morgan Private Wealth Advisors LLC |
15,000 |
259,000 |
0.07% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
14,100 |
244,000 |
0.07% |
|
|
| 35 |
BANK OF MONTREAL /CAN/ |
15,612 |
230,000 |
0.06% |
|
|
| 36 |
PDT Partners, LLC |
12,900 |
223,000 |
0.06% |
|
|
| 37 |
RHUMBLINE ADVISERS |
12,796 |
221,000 |
0.06% |
|
|
| 38 |
METROPOLITAN LIFE INSURANCE CO/NY |
12,426 |
215,000 |
0.06% |
|
|
| 39 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
10,882 |
188,000 |
0.05% |
|
|
| 40 |
Nationwide Fund Advisors |
10,265 |
177,000 |
0.05% |
|
|
| 41 |
BlackRock Group LTD |
8,098 |
140,000 |
0.04% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,021 |
121,000 |
0.03% |
|
|
| 43 |
BESSEMER GROUP INC |
5,169 |
90,000 |
0.03% |
|
|
| 44 |
WELLS FARGO & COMPANY/MN |
4,759 |
82,000 |
0.02% |
|
|
| 45 |
GLENMEDE TRUST CO NA |
4,373 |
75,000 |
0.02% |
|
|
| 46 |
BNP PARIBAS FINANCIAL MARKETS |
3,450 |
59,616 |
0.02% |
|
|
| 47 |
BlackRock Japan Co. Ltd |
1,018 |
18,000 |
0.01% |
|
|
| 48 |
BlackRock Finance, Inc. |
1,000 |
17,000 |
0.00% |
|
|
| 49 |
BANK OF AMERICA CORP /DE/ |
959 |
17,000 |
0.00% |
|
|
| 50 |
ROYAL BANK OF CANADA |
808 |
14,000 |
0.00% |
|
|
