| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 14,083,582 | 182,242,000 | 36.51% | ||
| 2 | FMR LLC | 3,968,945 | 51,358,000 | 10.29% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 3,266,045 | 42,263,000 | 8.47% | ||
| 4 | Cormorant Asset Management, LP | 2,071,964 | 26,811,000 | 5.37% | ||
| 5 | Rock Springs Capital Management LP | 1,975,000 | 25,557,000 | 5.12% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,837,593 | 23,778,000 | 4.76% | ||
| 7 | BlackRock Fund Advisors | 1,504,827 | 19,472,000 | 3.90% | ||
| 8 | EcoR1 Capital, LLC | 1,310,023 | 16,952,000 | 3.40% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 1,057,257 | 13,680,000 | 2.74% | ||
| 10 | FIRST MANHATTAN CO. LLC. | 1,053,628 | 13,633,000 | 2.73% | ||
| 11 | VANGUARD GROUP INC | 970,778 | 12,562,000 | 2.52% | ||
| 12 | Tekla Capital Management LLC | 707,636 | 9,157,000 | 1.83% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 618,643 | 8,005,000 | 1.60% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 412,173 | 5,334,000 | 1.07% | ||
| 15 | STATE STREET CORP | 402,415 | 5,207,000 | 1.04% | ||
| 16 | JPMORGAN CHASE & CO | 387,475 | 5,014,000 | 1.00% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 305,246 | 3,950,000 | 0.79% | ||
| 18 | NORTHERN TRUST CORP | 296,027 | 3,830,000 | 0.77% | ||
| 19 | DAFNA Capital Management LLC | 219,095 | 2,835,000 | 0.57% | ||
| 20 | WALL STREET ASSOCIATES | 189,700 | 2,455,000 | 0.49% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 172,088 | 2,226,000 | 0.45% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 151,813 | 1,964,000 | 0.39% | ||
| 23 | BlackRock Investment Management, LLC | 131,217 | 1,698,000 | 0.34% | ||
| 24 | Bank of New York Mellon Corp | 100,238 | 1,297,000 | 0.26% | ||
| 25 | AWM Investment Company, Inc. | 100,000 | 1,294,000 | 0.26% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 84,630 | 1,095,000 | 0.22% | ||
| 27 | PUTNAM INVESTMENTS LLC | 82,318 | 1,065,000 | 0.21% | ||
| 28 | BLACKROCK ADVISORS LLC | 72,656 | 940,000 | 0.19% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 66,097 | 855,000 | 0.17% | ||
| 30 | D. E. Shaw & Co., Inc. | 62,663 | 811,000 | 0.16% | ||
| 31 | ALPS ADVISORS INC | 60,236 | 779,000 | 0.16% | ||
| 32 | DEUTSCHE BANK AG\ | 60,231 | 778,000 | 0.16% | ||
| 33 | TFS CAPITAL LLC | 59,997 | 776,000 | 0.16% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 49,240 | 638,000 | 0.13% | ||
| 35 | RENAISSANCE TECHNOLOGIES LLC | 47,000 | 608,000 | 0.12% | ||
| 36 | TD ASSET MANAGEMENT INC | 43,400 | 562,000 | 0.11% | ||
| 37 | Swiss National Bank | 35,200 | 455,000 | 0.09% | ||
| 38 | ClariVest Asset Management LLC | 34,600 | 448,000 | 0.09% | ||
| 39 | DIMENSIONAL FUND ADVISORS LP | 34,041 | 440,000 | 0.09% | ||
| 40 | ProShare Advisors LLC | 32,886 | 426,000 | 0.09% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 32,800 | 424,000 | 0.08% | ||
| 42 | TEACHERS ADVISORS, LLC | 32,540 | 421,000 | 0.08% | ||
| 43 | RHUMBLINE ADVISERS | 30,619 | 396,000 | 0.08% | ||
| 44 | ROYCE & ASSOCIATES LP | 30,000 | 388,000 | 0.08% | ||
| 45 | ACUTA CAPITAL PARTNERS, LLC | 26,076 | 337,000 | 0.07% | ||
| 46 | Spark Investment Management LLC | 23,400 | 302,000 | 0.06% | ||
| 47 | MORGAN STANLEY | 22,942 | 296,000 | 0.06% | ||
| 48 | CREDIT SUISSE AG/ | 21,865 | 283,000 | 0.06% | ||
| 49 | GOLDMAN SACHS GROUP INC | 21,050 | 272,000 | 0.05% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 20,442 | 265,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
