| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 11,792,631 | 91,629,000 | 39.90% | ||
| 2 | FMR LLC | 4,009,649 | 31,155,000 | 13.57% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 2,300,481 | 17,875,000 | 7.78% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,508,115 | 11,718,000 | 5.10% | ||
| 5 | Cormorant Asset Management, LP | 1,481,075 | 11,508,000 | 5.01% | ||
| 6 | Tekla Capital Management LLC | 1,389,370 | 10,795,000 | 4.70% | ||
| 7 | Rock Springs Capital Management LP | 1,060,400 | 8,239,000 | 3.59% | ||
| 8 | BlackRock Fund Advisors | 1,023,951 | 7,956,000 | 3.46% | ||
| 9 | VANGUARD GROUP INC | 685,718 | 5,329,000 | 2.32% | ||
| 10 | FORESITE CAPITAL MANAGEMENT III, LLC | 648,340 | 5,038,000 | 2.19% | ||
| 11 | Foresite Capital Management II, LLC | 468,297 | 3,639,000 | 1.58% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 311,165 | 2,418,000 | 1.05% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 275,000 | 2,137,000 | 0.93% | ||
| 14 | STATE STREET CORP | 271,831 | 2,111,000 | 0.92% | ||
| 15 | NORTHERN TRUST CORP | 257,165 | 1,998,000 | 0.87% | ||
| 16 | Broadfin Capital, LLC | 216,180 | 1,680,000 | 0.73% | ||
| 17 | WALL STREET ASSOCIATES | 180,200 | 1,400,000 | 0.61% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 144,821 | 1,125,000 | 0.49% | ||
| 19 | DAFNA Capital Management LLC | 140,265 | 1,090,000 | 0.47% | ||
| 20 | TFS CAPITAL LLC | 125,618 | 976,000 | 0.43% | ||
| 21 | PUTNAM INVESTMENTS LLC | 109,328 | 849,000 | 0.37% | ||
| 22 | JPMORGAN CHASE & CO | 98,242 | 763,000 | 0.33% | ||
| 23 | Bank of New York Mellon Corp | 88,701 | 689,000 | 0.30% | ||
| 24 | BlackRock Investment Management, LLC | 83,361 | 648,000 | 0.28% | ||
| 25 | BLACKROCK ADVISORS LLC | 68,352 | 531,000 | 0.23% | ||
| 26 | D. E. Shaw & Co., Inc. | 60,381 | 469,000 | 0.20% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 58,843 | 457,000 | 0.20% | ||
| 28 | Spark Investment Management LLC | 54,500 | 423,000 | 0.18% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47,005 | 365,000 | 0.16% | ||
| 30 | TD ASSET MANAGEMENT INC | 44,500 | 346,000 | 0.15% | ||
| 31 | MORGAN STANLEY | 42,770 | 332,000 | 0.14% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 36,240 | 282,000 | 0.12% | ||
| 33 | CITIGROUP INC | 35,123 | 273,000 | 0.12% | ||
| 34 | Swiss National Bank | 35,200 | 265,000 | 0.12% | ||
| 35 | DEUTSCHE BANK AG\ | 33,187 | 257,000 | 0.11% | ||
| 36 | ClariVest Asset Management LLC | 32,300 | 251,000 | 0.11% | ||
| 37 | TEACHERS ADVISORS, LLC | 29,584 | 230,000 | 0.10% | ||
| 38 | ProShare Advisors LLC | 28,313 | 220,000 | 0.10% | ||
| 39 | CREDIT SUISSE AG/ | 25,596 | 198,000 | 0.09% | ||
| 40 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | 194,000 | 0.08% | ||
| 41 | SABBY MANAGEMENT, LLC | 22,278 | 173,000 | 0.08% | ||
| 42 | RHUMBLINE ADVISERS | 19,686 | 153,000 | 0.07% | ||
| 43 | METROPOLITAN LIFE INSURANCE CO/NY | 19,529 | 152,000 | 0.07% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 17,400 | 135,000 | 0.06% | ||
| 45 | DekaBank Deutsche Girozentrale | 17,500 | 132,000 | 0.06% | ||
| 46 | Nationwide Fund Advisors | 14,411 | 112,000 | 0.05% | ||
| 47 | GSA CAPITAL PARTNERS LLP | 13,300 | 103,000 | 0.04% | ||
| 48 | GOLDMAN SACHS GROUP INC | 12,991 | 101,000 | 0.04% | ||
| 49 | VIRTUS ETF ADVISERS LLC | 12,922 | 100,000 | 0.04% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,895 | 98,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
