| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 10,294,096 | 186,529,000 | 48.87% | ||
| 2 | FMR LLC | 3,303,912 | 59,867,000 | 15.69% | ||
| 3 | Cormorant Asset Management, LP | 1,481,075 | 26,837,000 | 7.03% | ||
| 4 | BlackRock Fund Advisors | 755,455 | 13,689,000 | 3.59% | ||
| 5 | Rock Springs Capital Management LP | 682,500 | 12,367,000 | 3.24% | ||
| 6 | Tekla Capital Management LLC | 639,370 | 11,585,000 | 3.04% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 571,444 | 10,355,000 | 2.71% | ||
| 8 | Foresite Capital Management II, LLC | 478,297 | 8,667,000 | 2.27% | ||
| 9 | VANGUARD GROUP INC | 394,723 | 7,153,000 | 1.87% | ||
| 10 | Broadfin Capital, LLC | 349,290 | 6,329,000 | 1.66% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 215,747 | 3,909,000 | 1.02% | ||
| 12 | STATE STREET CORP | 210,445 | 3,812,000 | 1.00% | ||
| 13 | NORTHERN TRUST CORP | 183,415 | 3,324,000 | 0.87% | ||
| 14 | WALL STREET ASSOCIATES | 180,200 | 3,265,000 | 0.86% | ||
| 15 | MORGAN STANLEY | 137,732 | 2,496,000 | 0.65% | ||
| 16 | PUTNAM INVESTMENTS LLC | 107,194 | 1,943,000 | 0.51% | ||
| 17 | JPMORGAN CHASE & CO | 97,179 | 1,761,000 | 0.46% | ||
| 18 | D. E. Shaw & Co., Inc. | 74,839 | 1,356,000 | 0.36% | ||
| 19 | BLACKROCK ADVISORS LLC | 65,959 | 1,195,000 | 0.31% | ||
| 20 | PRUDENTIAL FINANCIAL INC | 64,650 | 1,171,000 | 0.31% | ||
| 21 | GLOBEFLEX CAPITAL L P | 58,620 | 1,062,000 | 0.28% | ||
| 22 | BlackRock Investment Management, LLC | 57,990 | 1,051,000 | 0.28% | ||
| 23 | OXFORD ASSET MANAGEMENT LLP | 48,594 | 923,000 | 0.24% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 48,391 | 877,000 | 0.23% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 47,200 | 855,000 | 0.22% | ||
| 26 | Bank of New York Mellon Corp | 46,566 | 844,000 | 0.22% | ||
| 27 | ALPS ADVISORS INC | 34,195 | 620,000 | 0.16% | ||
| 28 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,854 | 559,000 | 0.15% | ||
| 29 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 30,000 | 544,000 | 0.14% | ||
| 30 | Numeric Investors LLC | 26,916 | 488,000 | 0.13% | ||
| 31 | TEACHERS ADVISORS, LLC | 24,387 | 442,000 | 0.12% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,940 | 434,000 | 0.11% | ||
| 33 | ProShare Advisors LLC | 23,296 | 422,000 | 0.11% | ||
| 34 | Trexquant Investment LP | 20,491 | 371,000 | 0.10% | ||
| 35 | ClariVest Asset Management LLC | 18,000 | 326,000 | 0.09% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 17,400 | 315,000 | 0.08% | ||
| 37 | BANK OF MONTREAL /CAN/ | 16,466 | 298,000 | 0.08% | ||
| 38 | RHUMBLINE ADVISERS | 15,586 | 282,000 | 0.07% | ||
| 39 | PDT Partners, LLC | 15,500 | 281,000 | 0.07% | ||
| 40 | Spark Investment Management LLC | 15,000 | 271,000 | 0.07% | ||
| 41 | GSA CAPITAL PARTNERS LLP | 14,700 | 266,000 | 0.07% | ||
| 42 | CREDIT SUISSE AG/ | 14,356 | 260,000 | 0.07% | ||
| 43 | VIRTUS ETF ADVISERS LLC | 13,717 | 249,000 | 0.07% | ||
| 44 | CITIGROUP INC | 13,377 | 242,000 | 0.06% | ||
| 45 | METROPOLITAN LIFE INSURANCE CO/NY | 12,426 | 225,000 | 0.06% | ||
| 46 | PRICE T ROWE ASSOCIATES INC /MD/ | 11,105 | 201,000 | 0.05% | ||
| 47 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,882 | 197,000 | 0.05% | ||
| 48 | Nationwide Fund Advisors | 10,600 | 192,000 | 0.05% | ||
| 49 | Swiss National Bank | 9,500 | 172,000 | 0.05% | ||
| 50 | DEUTSCHE BANK AG\ | 7,229 | 129,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
