| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 14,083,582 | 199,987,000 | 36.46% | ||
| 2 | FMR LLC | 3,324,846 | 47,213,000 | 8.61% | ||
| 3 | Cormorant Asset Management, LP | 2,071,964 | 29,422,000 | 5.36% | ||
| 4 | Rock Springs Capital Management LP | 2,000,000 | 28,400,000 | 5.18% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 1,935,305 | 27,481,000 | 5.01% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 1,836,196 | 26,073,000 | 4.75% | ||
| 7 | BlackRock Fund Advisors | 1,685,837 | 23,939,000 | 4.36% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,617,321 | 22,966,000 | 4.19% | ||
| 9 | EcoR1 Capital, LLC | 1,310,023 | 18,602,000 | 3.39% | ||
| 10 | FIRST MANHATTAN CO. LLC. | 1,221,128 | 17,340,000 | 3.16% | ||
| 11 | VANGUARD GROUP INC | 1,181,704 | 16,780,000 | 3.06% | ||
| 12 | Tekla Capital Management LLC | 639,370 | 9,079,000 | 1.66% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 486,588 | 6,910,000 | 1.26% | ||
| 14 | STATE STREET CORP | 462,228 | 6,565,000 | 1.20% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 440,496 | 6,255,000 | 1.14% | ||
| 16 | JPMORGAN CHASE & CO | 388,072 | 5,511,000 | 1.00% | ||
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 373,643 | 5,306,000 | 0.97% | ||
| 18 | MARSHALL WACE, LLP | 340,919 | 4,841,000 | 0.88% | ||
| 19 | NORTHERN TRUST CORP | 340,603 | 4,836,000 | 0.88% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 175,809 | 2,496,000 | 0.45% | ||
| 21 | DAFNA Capital Management LLC | 173,995 | 2,471,000 | 0.45% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 151,813 | 2,156,000 | 0.39% | ||
| 23 | EMORY UNIVERSITY | 139,357 | 1,979,000 | 0.36% | ||
| 24 | Bank of New York Mellon Corp | 139,269 | 1,978,000 | 0.36% | ||
| 25 | BlackRock Investment Management, LLC | 132,794 | 1,886,000 | 0.34% | ||
| 26 | BALYASNY ASSET MANAGEMENT L.P. | 130,000 | 1,846,000 | 0.34% | ||
| 27 | AWM Investment Company, Inc. | 100,000 | 1,420,000 | 0.26% | ||
| 28 | MORGAN STANLEY | 96,672 | 1,373,000 | 0.25% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 90,484 | 1,285,000 | 0.23% | ||
| 30 | PUTNAM INVESTMENTS LLC | 81,328 | 1,155,000 | 0.21% | ||
| 31 | TFS CAPITAL LLC | 73,069 | 1,038,000 | 0.19% | ||
| 32 | BLACKROCK ADVISORS LLC | 72,350 | 1,027,000 | 0.19% | ||
| 33 | AXIOM INVESTORS LLC /DE | 69,621 | 989,000 | 0.18% | ||
| 34 | D. E. Shaw & Co., Inc. | 68,358 | 971,000 | 0.18% | ||
| 35 | RENAISSANCE TECHNOLOGIES LLC | 66,300 | 941,000 | 0.17% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,397 | 914,000 | 0.17% | ||
| 37 | DEUTSCHE BANK AG\ | 61,762 | 876,000 | 0.16% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,656 | 790,000 | 0.14% | ||
| 39 | GOLDMAN SACHS GROUP INC | 55,378 | 786,000 | 0.14% | ||
| 40 | TD ASSET MANAGEMENT INC | 50,208 | 713,000 | 0.13% | ||
| 41 | Polar Capital LLP | 50,000 | 710,000 | 0.13% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 49,240 | 700,000 | 0.13% | ||
| 43 | TEACHERS ADVISORS, LLC | 47,230 | 671,000 | 0.12% | ||
| 44 | Swiss National Bank | 46,600 | 662,000 | 0.12% | ||
| 45 | ALPS ADVISORS INC | 45,455 | 645,000 | 0.12% | ||
| 46 | ClariVest Asset Management LLC | 37,500 | 533,000 | 0.10% | ||
| 47 | ProShare Advisors LLC | 36,265 | 515,000 | 0.09% | ||
| 48 | CREDIT SUISSE AG/ | 34,692 | 493,000 | 0.09% | ||
| 49 | DIMENSIONAL FUND ADVISORS LP | 34,041 | 483,000 | 0.09% | ||
| 50 | RHUMBLINE ADVISERS | 33,680 | 478,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
