| 1 |
NEA Management Company, LLC |
11,792,631 |
102,950,000 |
40.14% |
|
|
| 2 |
FMR LLC |
4,009,649 |
35,004,000 |
13.65% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
2,312,243 |
20,186,000 |
7.87% |
|
|
| 4 |
PRICE T ROWE ASSOCIATES INC /MD/ |
1,504,315 |
13,133,000 |
5.12% |
|
|
| 5 |
Cormorant Asset Management, LP |
1,499,226 |
13,088,000 |
5.10% |
|
|
| 6 |
Tekla Capital Management LLC |
1,389,370 |
12,129,000 |
4.73% |
|
|
| 7 |
Rock Springs Capital Management LP |
1,275,000 |
11,131,000 |
4.34% |
|
|
| 8 |
BlackRock Fund Advisors |
1,033,233 |
9,020,000 |
3.52% |
|
|
| 9 |
VANGUARD GROUP INC |
704,520 |
6,151,000 |
2.40% |
|
|
| 10 |
FORESITE CAPITAL MANAGEMENT III, LLC |
601,485 |
5,251,000 |
2.05% |
|
|
| 11 |
Foresite Capital Management II, LLC |
428,989 |
3,745,000 |
1.46% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
324,788 |
2,835,000 |
1.11% |
|
|
| 13 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
275,000 |
2,401,000 |
0.94% |
|
|
| 14 |
STATE STREET CORP |
268,689 |
2,345,000 |
0.91% |
|
|
| 15 |
JPMORGAN CHASE & CO |
262,556 |
2,292,000 |
0.89% |
|
|
| 16 |
NORTHERN TRUST CORP |
250,666 |
2,189,000 |
0.85% |
|
|
| 17 |
WALL STREET ASSOCIATES |
180,200 |
1,573,000 |
0.61% |
|
|
| 18 |
PUTNAM INVESTMENTS LLC |
159,433 |
1,391,000 |
0.54% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
146,837 |
1,281,000 |
0.50% |
|
|
| 20 |
Bank of New York Mellon Corp |
99,099 |
865,000 |
0.34% |
|
|
| 21 |
BlackRock Investment Management, LLC |
95,534 |
834,000 |
0.33% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
71,759 |
626,000 |
0.24% |
|
|
| 23 |
BLACKROCK ADVISORS LLC |
68,657 |
599,000 |
0.23% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
47,997 |
419,000 |
0.16% |
|
|
| 25 |
TD ASSET MANAGEMENT INC |
44,000 |
384,000 |
0.15% |
|
|
| 26 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
36,240 |
317,000 |
0.12% |
|
|
| 27 |
Swiss National Bank |
35,200 |
307,000 |
0.12% |
|
|
| 28 |
ClariVest Asset Management LLC |
34,100 |
298,000 |
0.12% |
|
|
| 29 |
TFS CAPITAL LLC |
34,134 |
298,000 |
0.12% |
|
|
| 30 |
TEACHERS ADVISORS, LLC |
32,540 |
284,000 |
0.11% |
|
|
| 31 |
GOLDMAN SACHS GROUP INC |
31,371 |
274,000 |
0.11% |
|
|
| 32 |
DAFNA Capital Management LLC |
30,000 |
262,000 |
0.10% |
|
SH |
| 33 |
ProShare Advisors LLC |
28,575 |
249,000 |
0.10% |
|
|
| 34 |
RHUMBLINE ADVISERS |
24,739 |
216,000 |
0.08% |
|
|
| 35 |
CREDIT SUISSE AG/ |
20,109 |
175,000 |
0.07% |
|
|
| 36 |
METROPOLITAN LIFE INSURANCE CO/NY |
19,131 |
167,000 |
0.07% |
|
|
| 37 |
NEW YORK STATE COMMON RETIREMENT FUND |
17,400 |
152,000 |
0.06% |
|
|
| 38 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
17,294 |
151,000 |
0.06% |
|
|
| 39 |
D. E. Shaw & Co., Inc. |
15,098 |
132,000 |
0.05% |
|
|
| 40 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
14,730 |
129,000 |
0.05% |
|
|
| 41 |
DEUTSCHE BANK AG\ |
14,562 |
126,000 |
0.05% |
|
|
| 42 |
Nationwide Fund Advisors |
14,411 |
126,000 |
0.05% |
|
|
| 43 |
AMERICAN INTERNATIONAL GROUP, INC. |
13,176 |
115,026 |
0.04% |
|
|
| 44 |
CITIGROUP INC |
11,270 |
99,000 |
0.04% |
|
|
| 45 |
ALLIANCEBERNSTEIN L.P. |
10,400 |
91,000 |
0.04% |
|
|
| 46 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
10,300 |
90,000 |
0.04% |
|
|
| 47 |
VOYA INVESTMENT MANAGEMENT LLC |
10,138 |
89,000 |
0.03% |
|
|
| 48 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
10,000 |
87,000 |
0.03% |
|
|
| 49 |
WELLS FARGO & COMPANY/MN |
9,882 |
86,000 |
0.03% |
|
|
| 50 |
MORGAN STANLEY |
9,129 |
79,000 |
0.03% |
|
|
