| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 2,009,080 | 38,695,000 | 17.99% | ||
| 2 | EcoR1 Capital, LLC | 1,574,107 | 30,317,000 | 14.10% | ||
| 3 | Visium Asset Management, LP | 1,500,000 | 28,890,000 | 13.43% | ||
| 4 | ORBIMED ADVISORS LLC | 1,397,100 | 26,908,000 | 12.51% | ||
| 5 | QVT Financial LP | 535,000 | 10,304,000 | 4.79% | ||
| 6 | HealthCor Management, L.P. | 505,369 | 9,733,000 | 4.53% | ||
| 7 | BlackRock Fund Advisors | 377,991 | 7,280,000 | 3.39% | ||
| 8 | VANGUARD GROUP INC | 377,741 | 7,275,000 | 3.38% | ||
| 9 | PUTNAM INVESTMENTS LLC | 370,000 | 7,126,000 | 3.31% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 356,595 | 6,868,000 | 3.19% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 332,103 | 6,396,000 | 2.97% | ||
| 12 | Rock Springs Capital Management LP | 313,500 | 6,038,000 | 2.81% | ||
| 13 | BAKER BROS. ADVISORS LP | 250,000 | 4,815,000 | 2.24% | ||
| 14 | FMR LLC | 210,699 | 4,058,000 | 1.89% | ||
| 15 | Iguana Healthcare Management, LLC | 175,000 | 3,371,000 | 1.57% | ||
| 16 | Ghost Tree Capital, LLC | 175,000 | 3,371,000 | 1.57% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 82,617 | 1,591,000 | 0.74% | ||
| 18 | Opus Point Partners Management, LLC | 65,000 | 1,252,000 | 0.58% | ||
| 19 | GILDER GAGNON HOWE & CO LLC | 61,614 | 1,187,000 | 0.55% | ||
| 20 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 57,308 | 1,103,000 | 0.51% | ||
| 21 | BlackRock Investment Management, LLC | 50,721 | 977,000 | 0.45% | ||
| 22 | Bank of New York Mellon Corp | 48,694 | 938,000 | 0.44% | ||
| 23 | NORTHERN TRUST CORP | 34,249 | 660,000 | 0.31% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 29,694 | 572,000 | 0.27% | ||
| 25 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,201 | 505,000 | 0.23% | ||
| 26 | TEACHERS ADVISORS, LLC | 21,201 | 408,000 | 0.19% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 20,668 | 399,000 | 0.19% | ||
| 28 | PDT Partners, LLC | 19,101 | 368,000 | 0.17% | ||
| 29 | DEERE & CO | 14,218 | 274,000 | 0.13% | ||
| 30 | METROPOLITAN LIFE INSURANCE CO/NY | 13,999 | 270,000 | 0.13% | ||
| 31 | CREDIT SUISSE AG/ | 12,311 | 237,000 | 0.11% | ||
| 32 | GOLDMAN SACHS GROUP INC | 11,952 | 230,000 | 0.11% | ||
| 33 | MORGAN STANLEY | 11,850 | 228,000 | 0.11% | ||
| 34 | RENAISSANCE TECHNOLOGIES LLC | 11,560 | 223,000 | 0.10% | ||
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 11,240 | 216,000 | 0.10% | ||
| 36 | RHUMBLINE ADVISERS | 11,135 | 214,000 | 0.10% | ||
| 37 | AQR CAPITAL MANAGEMENT LLC | 10,768 | 207,000 | 0.10% | ||
| 38 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,026 | 193,000 | 0.09% | ||
| 39 | BLAIR WILLIAM & CO/IL | 10,000 | 192,000 | 0.09% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 9,180 | 177,000 | 0.08% | ||
| 41 | Nationwide Fund Advisors | 9,112 | 175,000 | 0.08% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 8,659 | 167,000 | 0.08% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 8,407 | 161,919 | 0.08% | ||
| 44 | BLACKROCK ADVISORS LLC | 8,091 | 156,000 | 0.07% | ||
| 45 | Invesco Ltd. | 5,876 | 113,000 | 0.05% | ||
| 46 | DEUTSCHE BANK AG\ | 3,447 | 66,000 | 0.03% | ||
| 47 | UBS Group AG | 2,002 | 39,000 | 0.02% | ||
| 48 | CITIGROUP INC | 1,186 | 23,000 | 0.01% | ||
| 49 | BNP PARIBAS FINANCIAL MARKETS | 1,194 | 22,996 | 0.01% | ||
| 50 | ROYAL BANK OF CANADA | 791 | 15,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
