| 1 |
EcoR1 Capital, LLC |
2,943,164 |
35,759,000 |
25.36% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
2,077,830 |
25,246,000 |
17.91% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,397,100 |
16,975,000 |
12.04% |
|
|
| 4 |
ACUTA CAPITAL PARTNERS, LLC |
976,599 |
11,866,000 |
8.42% |
|
|
| 5 |
PERCEPTIVE ADVISORS LLC |
714,354 |
8,679,000 |
6.16% |
|
|
| 6 |
QVT Financial LP |
791,586 |
8,175,000 |
5.80% |
|
|
| 7 |
VANGUARD GROUP INC |
453,236 |
5,507,000 |
3.91% |
|
|
| 8 |
Rock Springs Capital Management LP |
390,000 |
4,739,000 |
3.36% |
|
|
| 9 |
PUTNAM INVESTMENTS LLC |
364,550 |
4,429,000 |
3.14% |
|
|
| 10 |
MILLENNIUM MANAGEMENT LLC |
359,905 |
4,373,000 |
3.10% |
|
|
| 11 |
Avoro Capital Advisors LLC |
270,289 |
3,284,000 |
2.33% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
265,487 |
3,226,000 |
2.29% |
|
|
| 13 |
BAKER BROS. ADVISORS LP |
250,000 |
3,038,000 |
2.15% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
74,038 |
899,000 |
0.64% |
|
|
| 15 |
NORTHERN TRUST CORP |
50,153 |
609,000 |
0.43% |
|
|
| 16 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
49,000 |
595,000 |
0.42% |
Put |
|
| 17 |
BlackRock Fund Advisors |
48,385 |
588,000 |
0.42% |
|
|
| 18 |
DIMENSIONAL FUND ADVISORS LP |
46,027 |
559,000 |
0.40% |
|
|
| 19 |
BLAIR WILLIAM & CO/IL |
40,850 |
496,000 |
0.35% |
|
|
| 20 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
40,768 |
495,000 |
0.35% |
|
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
31,419 |
382,000 |
0.27% |
|
|
| 22 |
B. Riley Wealth Advisors, Inc. |
14,000 |
171,000 |
0.12% |
|
|
| 23 |
Bank of New York Mellon Corp |
12,148 |
148,000 |
0.10% |
|
|
| 24 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
11,240 |
137,000 |
0.10% |
|
|
| 25 |
ACUTA CAPITAL PARTNERS, LLC |
10,000 |
122,000 |
0.09% |
Call |
|
| 26 |
DEUTSCHE BANK AG\ |
9,400 |
114,000 |
0.08% |
|
|
| 27 |
MORGAN STANLEY |
6,380 |
78,000 |
0.06% |
|
|
| 28 |
SIMPLEX TRADING, LLC |
4,885 |
59,000 |
0.04% |
|
|
| 29 |
ACADIAN ASSET MANAGEMENT LLC |
4,242 |
52,000 |
0.04% |
|
|
| 30 |
FNY Managed Accounts LLC |
3,800 |
46,170 |
0.03% |
|
|
| 31 |
Segantii Capital Management Ltd |
3,000 |
35,000 |
0.02% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
2,704 |
33,000 |
0.02% |
|
|
| 33 |
BlackRock Investment Management, LLC |
2,417 |
29,000 |
0.02% |
|
|
| 34 |
GROUP ONE TRADING LLC |
1,700 |
21,000 |
0.01% |
|
|
| 35 |
UBS Group AG |
1,054 |
13,000 |
0.01% |
|
|
| 36 |
THOMPSON DAVIS & CO., INC. |
750 |
9,000 |
0.01% |
|
|
| 37 |
FEDERATED HERMES, INC. |
624 |
7,000 |
0.00% |
|
|
| 38 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
72 |
1,000 |
0.00% |
|
|
| 39 |
BANK OF AMERICA CORP /DE/ |
1 |
0 |
0.00% |
|
|
