| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 1,995,927 | 26,426,000 | 18.54% | ||
| 2 | EcoR1 Capital, LLC | 1,574,107 | 20,841,000 | 14.62% | ||
| 3 | Visium Asset Management, LP | 1,500,000 | 19,860,000 | 13.93% | ||
| 4 | ORBIMED ADVISORS LLC | 1,350,000 | 17,874,000 | 12.54% | ||
| 5 | QVT Financial LP | 535,000 | 7,083,000 | 4.97% | ||
| 6 | HealthCor Management, L.P. | 475,000 | 6,289,000 | 4.41% | ||
| 7 | PERCEPTIVE ADVISORS LLC | 425,000 | 5,627,000 | 3.95% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 401,792 | 5,320,000 | 3.73% | ||
| 9 | PUTNAM INVESTMENTS LLC | 370,000 | 4,899,000 | 3.44% | ||
| 10 | Rock Springs Capital Management LP | 317,500 | 4,204,000 | 2.95% | ||
| 11 | VANGUARD GROUP INC | 314,415 | 4,163,000 | 2.92% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 268,282 | 3,552,000 | 2.49% | ||
| 13 | BAKER BROS. ADVISORS LP | 250,000 | 3,310,000 | 2.32% | ||
| 14 | RTW INVESTMENTS, LP | 204,000 | 2,701,000 | 1.89% | ||
| 15 | Iguana Healthcare Management, LLC | 150,000 | 1,986,000 | 1.39% | ||
| 16 | Ghost Tree Capital, LLC | 125,000 | 1,655,000 | 1.16% | ||
| 17 | FMR LLC | 100,000 | 1,324,000 | 0.93% | ||
| 18 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 1,324,000 | 0.93% | ||
| 19 | Opus Point Partners Management, LLC | 65,000 | 861,000 | 0.60% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 58,267 | 771,000 | 0.54% | ||
| 21 | MONASHEE INVESTMENT MANAGEMENT LLC | 48,000 | 636,000 | 0.45% | ||
| 22 | MORGAN STANLEY | 30,597 | 405,000 | 0.28% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 24,160 | 320,000 | 0.22% | ||
| 24 | TUDOR INVESTMENT CORP ET AL | 23,750 | 314,000 | 0.22% | ||
| 25 | GOLDMAN SACHS GROUP INC | 17,939 | 238,000 | 0.17% | ||
| 26 | Spark Investment Management LLC | 17,900 | 236,000 | 0.17% | ||
| 27 | EAGLE GLOBAL ADVISORS LLC | 10,925 | 145,000 | 0.10% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 11,240 | 94,000 | 0.07% | ||
| 29 | WELLS FARGO & COMPANY/MN | 3,000 | 40,000 | 0.03% | ||
| 30 | PRELUDE CAPITAL MANAGEMENT, LLC | 2,600 | 34,000 | 0.02% | ||
| 31 | CITIGROUP INC | 1,000 | 13,000 | 0.01% | ||
| 32 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 839 | 11,000 | 0.01% | ||
| 33 | Tower Research Capital LLC (TRC) | 32 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
