| 1 |
JENNISON ASSOCIATES LLC |
2,019,384 |
19,305,000 |
17.63% |
|
|
| 2 |
EcoR1 Capital, LLC |
1,887,069 |
18,040,000 |
16.48% |
|
|
| 3 |
Visium Asset Management, LP |
1,600,001 |
15,296,000 |
13.97% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
1,397,100 |
13,356,000 |
12.20% |
|
|
| 5 |
QVT Financial LP |
535,000 |
5,115,000 |
4.67% |
|
|
| 6 |
VANGUARD GROUP INC |
415,845 |
3,976,000 |
3.63% |
|
|
| 7 |
MILLENNIUM MANAGEMENT LLC |
380,099 |
3,634,000 |
3.32% |
|
|
| 8 |
BlackRock Fund Advisors |
373,765 |
3,573,000 |
3.26% |
|
|
| 9 |
Rock Springs Capital Management LP |
371,000 |
3,547,000 |
3.24% |
|
|
| 10 |
PUTNAM INVESTMENTS LLC |
370,000 |
3,537,000 |
3.23% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
362,977 |
3,470,000 |
3.17% |
|
|
| 12 |
HealthCor Management, L.P. |
318,621 |
3,046,000 |
2.78% |
|
|
| 13 |
BAKER BROS. ADVISORS LP |
250,000 |
2,390,000 |
2.18% |
|
|
| 14 |
FMR LLC |
210,100 |
2,009,000 |
1.83% |
|
|
| 15 |
NORTHERN TRUST CORP |
167,293 |
1,599,000 |
1.46% |
|
|
| 16 |
Iguana Healthcare Management, LLC |
150,000 |
1,434,000 |
1.31% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
85,535 |
817,000 |
0.75% |
|
|
| 18 |
MORGAN STANLEY |
62,996 |
603,000 |
0.55% |
|
|
| 19 |
BlackRock Investment Management, LLC |
51,812 |
495,000 |
0.45% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
45,841 |
438,000 |
0.40% |
|
|
| 21 |
Bank of New York Mellon Corp |
45,829 |
438,000 |
0.40% |
|
|
| 22 |
DIMENSIONAL FUND ADVISORS LP |
41,459 |
396,000 |
0.36% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
26,101 |
250,000 |
0.23% |
|
|
| 24 |
PDT Partners, LLC |
21,601 |
207,000 |
0.19% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
21,201 |
203,000 |
0.19% |
|
|
| 26 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
20,668 |
198,000 |
0.18% |
|
|
| 27 |
AQR CAPITAL MANAGEMENT LLC |
19,727 |
189,000 |
0.17% |
|
|
| 28 |
B. Riley Wealth Advisors, Inc. |
19,257 |
185,000 |
0.17% |
|
|
| 29 |
BLAIR WILLIAM & CO/IL |
19,000 |
181,000 |
0.17% |
|
|
| 30 |
BANK OF AMERICA CORP /DE/ |
16,467 |
157,000 |
0.14% |
|
|
| 31 |
GSA CAPITAL PARTNERS LLP |
15,071 |
144,000 |
0.13% |
|
|
| 32 |
Opus Point Partners Management, LLC |
15,000 |
143,000 |
0.13% |
|
|
| 33 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
13,328 |
127,000 |
0.12% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
13,100 |
125,000 |
0.11% |
|
|
| 35 |
RHUMBLINE ADVISERS |
12,719 |
122,000 |
0.11% |
|
|
| 36 |
GOLDMAN SACHS GROUP INC |
12,503 |
120,000 |
0.11% |
|
|
| 37 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
11,240 |
107,000 |
0.10% |
|
|
| 38 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
10,026 |
96,000 |
0.09% |
|
|
| 39 |
BLACKROCK ADVISORS LLC |
9,626 |
92,000 |
0.08% |
|
|
| 40 |
Nationwide Fund Advisors |
9,112 |
87,000 |
0.08% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
8,417 |
80,000 |
0.07% |
|
|
| 42 |
PANAGORA ASSET MANAGEMENT INC |
4,708 |
45,000 |
0.04% |
|
|
| 43 |
DEUTSCHE BANK AG\ |
3,954 |
37,000 |
0.03% |
|
|
| 44 |
BNP PARIBAS FINANCIAL MARKETS |
3,360 |
32,122 |
0.03% |
|
|
| 45 |
Tower Research Capital LLC (TRC) |
1,350 |
13,000 |
0.01% |
|
|
| 46 |
CITIGROUP INC |
1,094 |
11,000 |
0.01% |
|
|
| 47 |
METROPOLITAN LIFE INSURANCE CO/NY |
1,184 |
11,000 |
0.01% |
|
|
| 48 |
ROYAL BANK OF CANADA |
575 |
5,000 |
0.00% |
|
|
| 49 |
BARCLAYS PLC |
75 |
1,000 |
0.00% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
75 |
1,000 |
0.00% |
|
|
