| 1 |
EcoR1 Capital, LLC |
2,943,164 |
16,335,000 |
28.42% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
2,037,542 |
11,308,000 |
19.68% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,397,100 |
7,754,000 |
13.49% |
|
|
| 4 |
QVT Financial LP |
807,601 |
3,740,000 |
6.51% |
|
|
| 5 |
VANGUARD GROUP INC |
434,374 |
2,411,000 |
4.20% |
|
|
| 6 |
MILLENNIUM MANAGEMENT LLC |
425,943 |
2,364,000 |
4.11% |
|
|
| 7 |
Rock Springs Capital Management LP |
390,000 |
2,165,000 |
3.77% |
|
|
| 8 |
PUTNAM INVESTMENTS LLC |
370,000 |
2,054,000 |
3.57% |
|
|
| 9 |
BlackRock Institutional Trust Company, N.A. |
265,583 |
1,474,000 |
2.56% |
|
|
| 10 |
Avoro Capital Advisors LLC |
260,982 |
1,448,000 |
2.52% |
|
|
| 11 |
BAKER BROS. ADVISORS LP |
250,000 |
1,388,000 |
2.42% |
|
|
| 12 |
ACUTA CAPITAL PARTNERS, LLC |
225,444 |
1,251,000 |
2.18% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
90,362 |
502,000 |
0.87% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
72,309 |
401,000 |
0.70% |
|
|
| 15 |
Paloma Partners Management Co |
56,603 |
314,000 |
0.55% |
|
|
| 16 |
CREDIT SUISSE AG/ |
49,188 |
273,000 |
0.48% |
|
|
| 17 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
47,582 |
264,000 |
0.46% |
|
|
| 18 |
DIMENSIONAL FUND ADVISORS LP |
41,459 |
230,000 |
0.40% |
|
|
| 19 |
BLAIR WILLIAM & CO/IL |
40,850 |
227,000 |
0.40% |
|
|
| 20 |
NORTHERN TRUST CORP |
39,550 |
220,000 |
0.38% |
|
|
| 21 |
DIALECTIC CAPITAL MANAGEMENT, LP |
39,512 |
219,000 |
0.38% |
|
|
| 22 |
BlackRock Fund Advisors |
38,695 |
215,000 |
0.37% |
|
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
24,525 |
136,000 |
0.24% |
|
|
| 24 |
GOLDMAN SACHS GROUP INC |
24,415 |
136,000 |
0.24% |
|
|
| 25 |
B. Riley Wealth Advisors, Inc. |
22,714 |
127,000 |
0.22% |
|
|
| 26 |
DEUTSCHE BANK AG\ |
16,574 |
91,000 |
0.16% |
|
|
| 27 |
LMR Partners LLP |
15,663 |
87,000 |
0.15% |
|
|
| 28 |
Bank of New York Mellon Corp |
15,135 |
84,000 |
0.15% |
|
|
| 29 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
11,240 |
62,000 |
0.11% |
|
|
| 30 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
10,026 |
56,000 |
0.10% |
|
|
| 31 |
BANK OF AMERICA CORP /DE/ |
5,178 |
29,000 |
0.05% |
|
|
| 32 |
MORGAN STANLEY |
4,641 |
26,000 |
0.05% |
|
|
| 33 |
BARCLAYS PLC |
3,579 |
20,000 |
0.03% |
|
|
| 34 |
BLACKROCK ADVISORS LLC |
2,704 |
15,000 |
0.03% |
|
|
| 35 |
BlackRock Investment Management, LLC |
2,458 |
14,000 |
0.02% |
|
|
| 36 |
JPMORGAN CHASE & CO |
1,165 |
7,000 |
0.01% |
|
|
| 37 |
Tower Research Capital LLC (TRC) |
1,178 |
7,000 |
0.01% |
|
|
| 38 |
PRELUDE CAPITAL MANAGEMENT, LLC |
900 |
5,000 |
0.01% |
|
|
| 39 |
UBS Group AG |
791 |
4,000 |
0.01% |
|
|
| 40 |
THOMPSON DAVIS & CO., INC. |
500 |
3,000 |
0.01% |
|
|
| 41 |
Creative Planning |
400 |
2,000 |
0.00% |
|
|
| 42 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
72 |
0 |
0.00% |
|
|
