| 1 |
EcoR1 Capital, LLC |
2,943,164 |
21,220,000 |
26.74% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
2,030,045 |
14,637,000 |
18.45% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,397,100 |
10,073,000 |
12.70% |
|
|
| 4 |
PERCEPTIVE ADVISORS LLC |
777,669 |
5,606,000 |
7.07% |
|
|
| 5 |
QVT Financial LP |
807,601 |
5,059,000 |
6.38% |
|
|
| 6 |
VANGUARD GROUP INC |
434,374 |
3,131,000 |
3.95% |
|
|
| 7 |
Rock Springs Capital Management LP |
390,000 |
2,812,000 |
3.54% |
|
|
| 8 |
PUTNAM INVESTMENTS LLC |
370,000 |
2,668,000 |
3.36% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
363,704 |
2,622,000 |
3.30% |
|
|
| 10 |
ACUTA CAPITAL PARTNERS, LLC |
314,211 |
2,265,000 |
2.85% |
|
|
| 11 |
Avoro Capital Advisors LLC |
268,119 |
1,933,000 |
2.44% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
267,699 |
1,930,000 |
2.43% |
|
|
| 13 |
BAKER BROS. ADVISORS LP |
250,000 |
1,803,000 |
2.27% |
|
|
| 14 |
SABBY MANAGEMENT, LLC |
75,200 |
542,000 |
0.68% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
72,354 |
521,000 |
0.66% |
|
|
| 16 |
BlackRock Fund Advisors |
45,321 |
327,000 |
0.41% |
|
|
| 17 |
DIMENSIONAL FUND ADVISORS LP |
41,459 |
299,000 |
0.38% |
|
|
| 18 |
BLAIR WILLIAM & CO/IL |
40,850 |
295,000 |
0.37% |
|
|
| 19 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
40,768 |
294,000 |
0.37% |
|
|
| 20 |
NORTHERN TRUST CORP |
40,451 |
292,000 |
0.37% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
22,901 |
165,000 |
0.21% |
|
|
| 22 |
B. Riley Wealth Advisors, Inc. |
19,757 |
143,000 |
0.18% |
|
|
| 23 |
CREDIT SUISSE AG/ |
15,065 |
109,000 |
0.14% |
|
|
| 24 |
THOMPSON DAVIS & CO., INC. |
14,786 |
107,000 |
0.13% |
|
|
| 25 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
14,722 |
106,000 |
0.13% |
|
|
| 26 |
Bank of New York Mellon Corp |
12,920 |
93,000 |
0.12% |
|
|
| 27 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
11,240 |
81,000 |
0.10% |
|
|
| 28 |
MORGAN STANLEY |
8,055 |
58,000 |
0.07% |
|
|
| 29 |
Tower Research Capital LLC (TRC) |
6,810 |
50,000 |
0.06% |
|
|
| 30 |
PRELUDE CAPITAL MANAGEMENT, LLC |
6,000 |
43,000 |
0.05% |
|
|
| 31 |
BLACKROCK ADVISORS LLC |
2,704 |
19,000 |
0.02% |
|
|
| 32 |
BlackRock Investment Management, LLC |
2,548 |
18,000 |
0.02% |
|
|
| 33 |
JPMORGAN CHASE & CO |
2,307 |
17,000 |
0.02% |
|
|
| 34 |
BANK OF AMERICA CORP /DE/ |
1,028 |
7,000 |
0.01% |
|
|
| 35 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
72 |
1,000 |
0.00% |
|
|
